Sustained Consumption of a Decaffeinated Green Coffee Nutraceutical Has Limited Effects on Phenolic Metabolism and Bioavailability in Overweight/Obese Subjects

Seguido, Miguel A.; Tarradas, Rosa María; González-Rámila, Susana; García-Cordero, Joaquin; Sarriá, Beatriz; Bravo, Laura; Mateos, Raquel

doi:10.3390/nu14122445

Cited by 7 publications

(13 citation statements)

References 30 publications

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“…Similarly, physiologically relevant doses of HHA (1–10 μM) showed antioxidant activity reducing ROS levels ( Figure 6 C) and recovering endogenous antioxidants (GSH levels, Figure 7 , and GPx and GR activity, Figure 8 ). These results are of special relevance considering that HHA is a colonic metabolite extensively detected in plasma and urine after consumption of different phenolic compounds, not only hydroxycinnamic acids from coffee [ 24 , 25 ] but also flavonoids such as monomeric and oligomeric flavan-3-ols from cocoa, nuts, etc. [ 61 , 62 ], citrus flavanones [ 63 ], or berries’ anthocyanins [ 64 ] among other fruits.…”

Section: Discussionmentioning

confidence: 99%

“…In a bioavailability study carried out in humans with a blend of green/roasted coffee (35:65), among the most abundant groups of coffee phenol metabolites of colonic origin (75.7% of total urinary metabolites) were dihydrohydroxycinnamic acids and their phase II derivatives, in addition to feruloylglycine. Among the dihydrohydroxycinnamate metabolites outstand dihydroferulic acid (DHFA) and dihydrocaffeic acid (DHCA) [ 24 , 25 ]. These metabolites reach micromolar concentrations in plasma 5–10 h after the intake of coffee [ 24 , 25 , 26 , 27 ].…”

Section: Introductionmentioning

confidence: 99%

“…Among the dihydrohydroxycinnamate metabolites outstand dihydroferulic acid (DHFA) and dihydrocaffeic acid (DHCA) [ 24 , 25 ]. These metabolites reach micromolar concentrations in plasma 5–10 h after the intake of coffee [ 24 , 25 , 26 , 27 ]. In addition to these microbial metabolites, derivatives of hydroxyhippuric acid (HHA) were present in both urine and plasma and amounted up to 10 µM in 24 h urine [ 24 , 25 ], although these compounds are not exclusively formed during hydroxycinnamic acid biotransformation.…”

Section: Introductionmentioning

confidence: 99%

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Colonic Coffee Phenols Metabolites, Dihydrocaffeic, Dihydroferulic, and Hydroxyhippuric Acids Protect Hepatic Cells from TNF-α-Induced Inflammation and Oxidative Stress

Sánchez-Medina

Redondo-Puente

Dupak

et al. 2023

IJMS

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Coffee presents beneficial health properties, including antiobesity effects. However, its effects on inflammation are controversial. Hydroxycinnamic acids are the main coffee phenolic bioactive compounds. In human bioavailability studies carried out with coffee, among the most abundant compounds found in urine and plasma were the colonic metabolites, dihydrocaffeic (DHCA), dihydroferulic (DHFA), and hydroxyhippuric (HHA) acids. To understand the hepato-protective potential of these three compounds, we tested whether treatment with realistic concentrations (0.5–10 µM) were effective to counteract inflammatory process and oxidative status induced by tumor necrosis factor α (TNF-α). First, we established a novel model of inflammation/oxidation using TNF-α and HepG2 cells. Afterwards, we evaluated the activity of DHCA, DHFA, and HHA against the inflammatory/oxidative challenge through the determination of the inflammatory mediators, interleukins (IL)-6, and IL-8 and chemokines, monocyte chemoattractant protein-1, and macrophage inflammatory protein-1, as well as the levels of biomarkers of oxidative stress, such as reactive oxygen species, reduced glutathione, and the antioxidant enzymes glutathione peroxidase and reductase. Results showed that all three compounds have a potential hepato-protective effect against the induced inflammatory/oxidative insult.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Colonic Coffee Phenols Metabolites, Dihydrocaffeic, Dihydroferulic, and Hydroxyhippuric Acids Protect Hepatic Cells from TNF-α-Induced Inflammation and Oxidative Stress

Sánchez-Medina

Redondo-Puente

Dupak

et al. 2023

IJMS

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“…6 The aptness and efficiency of GCBE in weight management have been exhaustively discussed in previous studies that provided accumulating evidence regarding the auspicious utilization of GCBE as an anti-obesity supplement in animals and clinical studies. 2,4,5,7 Upon absorption of GCBE from the intestine, 8 GCBE may attain its anti-obesity effect by several mechanisms. These mechanisms include accelerating lipolysis, suppressing lipogenesis, restraining the accumulation of hepatic triglycerides, and changing adipokine plasma levels and body fat distribution.…”

Section: ■ Introductionmentioning

confidence: 99%

“…Upon absorption of GCBE from the intestine, 8 GCBE may attain its anti-obesity effect by several mechanisms. These mechanisms include accelerating lipolysis, suppressing lipogenesis, restraining the accumulation of hepatic triglycerides, and changing adipokine plasma levels and body fat distribution.…”

Section: Introductionmentioning

confidence: 99%

Unroasted Green Coffee Extract-Loaded Solid Lipid Nanoparticles for Enhancing Intestinal Permeation

Moussa,

Teaima,

Attia

et al. 2023

ACS Omega

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Green coffee bean extract (GCBE) provides diversified health benefits. However, its reported low bioavailability impeded its utilization in various applications. In this study, GCBE-loaded solid lipid nanoparticles (SLNs) were prepared to improve the bioavailability through enhanced intestinal absorption of GCBE. During the preparation of promising GCBE-loaded SLNs, the lipid concentration, surfactant concentration, and co-surfactant amount are crucial that were optimized using the Box–Behnken design, while particle size, polydispersity index (PDI), ζ-potential, entrapment efficiency, and cumulative drug release were the measured responses. GCBE-SLNs were successfully developed by a high shear homogenization technique using geleol as a solid lipid, tween 80 as a surfactant, and propylene glycol as Co-SAA. The optimized SLNs contained 5.8% geleol, 5.9% tween 80, and 80.4 mg PG resulting in a small particle size of 235.7 ± 12.5 nm, reasonably acceptable PDI of 0.417 ± 0.023, and ζ-potential of −15 ± 0.14 mV, with a high entrapment efficiency of 58.3 ± 0.85% and cumulative release of 7575 ± 0.78%. Furthermore, the performance of the optimized GCBE-SLN was evaluated using an ex vivo everted sac model where the intestinal permeation of GCBE was improved due to nanoencapsulation using SLN. Consequently, the results enlightened the auspicious potential of exploiting oral GCBE-SLNs for boosting intestinal absorption of chlorogenic acid.

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A fisiopatologia da obesidade e sua abordagem terapêutica nutricional com uso de nutracêuticos

Machado

Almeida

Maynard

2023

RSD

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A obesidade acende um alerta na atualidade, que pode ser um problema de saúde pública de caráter epidêmico, sobrecarregando o Sistema Único de Saúde (SUS). É uma doença multifatorial de risco para diversas patologias, como diabetes, hipertensão, síndrome metabólica, problemas cardiovasculares, ortopédicos e pulmonares. Suas causas estão relacionadas a um estilo de vida sedentário, alimentação desajustada ao estado nutricional, genética, problemas comportamentais e ambiente obesogênico. Esse trabalho teve como objetivo trazer a terapêutica nutricional no tratamento da obesidade, como uso de nutracêuticos associados. Foi realizada uma revisão da literatura com artigos publicados nos últimos 8 anos. Como resultado, foi verificado que o uso de alguns nutracêuticos apresentou resultados positivos, como a melhora do perfil lipídico, de marcadores inflamatórios e redução do IMC. Porém, se faz necessária a realização de mais pesquisas, mais longas e com público mais abrangente, já que as pesquisas realizadas foram feitas em pequenas amostras e estudos em um pequeno espaço de tempo, apresentando resultados inconsistentes na perda de peso e perda de massa gorda em si, o que impede uma melhor e mais precisa análise sobre o assunto abordado, entre diversas variáveis relevantes.

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Sustained Consumption of a Decaffeinated Green Coffee Nutraceutical Has Limited Effects on Phenolic Metabolism and Bioavailability in Overweight/Obese Subjects

Cited by 7 publications

References 30 publications

Colonic Coffee Phenols Metabolites, Dihydrocaffeic, Dihydroferulic, and Hydroxyhippuric Acids Protect Hepatic Cells from TNF-α-Induced Inflammation and Oxidative Stress

Colonic Coffee Phenols Metabolites, Dihydrocaffeic, Dihydroferulic, and Hydroxyhippuric Acids Protect Hepatic Cells from TNF-α-Induced Inflammation and Oxidative Stress

Unroasted Green Coffee Extract-Loaded Solid Lipid Nanoparticles for Enhancing Intestinal Permeation

A fisiopatologia da obesidade e sua abordagem terapêutica nutricional com uso de nutracêuticos

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