Sustained clinical and structural benefit after joint distraction in the treatment of severe knee osteoarthritis

Abstract

Clinical improvement by KJD treatment is sustained for at least 2 years. Cartilage repair is still present after 2 years (MRI) and the newly formed tissue continues to be mechanically resilient as shown by an increased JSW under weight-bearing conditions.

Quality of Life of Elderly and Obese Animal Models with Severe Knee Osteoarthritis after a Single Injection of Mesenchymal Stem Cells

“…The ARomDe score monitors the quality of life via the measurement of three dimensions, including pain and function recovery and behavior. It is consistent with many previous studies, which generally evaluate the improvement of models and human with knee osteoarthritis via the achievement of pain relief [2,7,14,19,20,26,28,29] and function recovery [1,2,26,27] and emotional behavior [1,19,20,27].…”

“…In severe knee OA, conservative treatment only provides temporary relief of clinical symptoms. Total knee replacement is required [7]. However, no treatment has been shown as ideal, so far, regarding their side effects.…”

Joint distraction attenuates osteoarthritis by reducing secondary inflammation, cartilage degeneration and subchondral bone aberrant change

“…In all these studies, they have demonstrated that the joint space width (JSW) on weight-bearing X-rays had increased after treatment. In a few studies they have also performed arthroscopic evaluation 8,9,12 and/or MRI evaluation 9,10,12 to showed cartilage repair after the joint distraction therapy. Intema et al 10 analyzed biochemical markers for collagen type II turnover and showed an increase of synthesis over release, suggesting that the hyaline nature of the newly formed tissue.…”

Knee Joint Distraction as an Alternative Surgical Treatment for Osteoarthritis: Rationale and Design of two Randomized Controlled Trials (vs High Tibial Osteotomy and Total Knee Prosthesis)

“…Only one prospective open uncontrolled trial has been performed. Follow-up of the 20 treated patients is reported on at one, two, and five years post-treatment [43,44] (ms under review). Clinical benefit with cartilaginous tissue repair has been demonstrated to sustain for up to five years after treatment in over three-quarter of the patients treated.…”