Sustained Attention Performance during Sleep Deprivation Associates with Instability in Behavior and Physiologic Measures at Baseline

Cytokines such as TNFα play an integral role in sleep/wake regulation and have recently been hypothesized to be involved in cognitive impairment due to sleep deprivation. We examined the effect of a guanine to adenine substitution at position 308 in the TNFα gene (TNFα G308A) on psychomotor vigilance performance impairment during total sleep deprivation. A total of 88 healthy women and men (ages 22–40) participated in one of five laboratory total sleep deprivation experiments. Performance on a psychomotor vigilance test (PVT) was measured every 2 to 3 h. The TNFα 308A allele, which is less common than the 308G allele, was associated with greater resilience to psychomotor vigilance performance impairment during total sleep deprivation (regardless of time of day), and also provided a small performance benefit at baseline. The effect of genotype on resilience persisted when controlling for between-subjects differences in age, gender, race/ethnicity, and baseline sleep duration. The TNFα G308A polymorphism predicted less than 10% of the overall between-subjects variance in performance impairment during sleep deprivation. Nonetheless, the differential effect of the polymorphism at the peak of performance impairment was more than 50% of median performance impairment at that time, which is sizeable compared to the effects of other genotypes reported in the literature. Our findings provided evidence for a role of TNFα in the effects of sleep deprivation on psychomotor vigilance performance. Furthermore, the TNFα G308A polymorphism may have predictive potential in a biomarker panel for the assessment of resilience to psychomotor vigilance performance impairment due to sleep deprivation.

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“…These baseline differences were significantly predictive of performance impairment during TSD ( F 1,81 =31.47, P <0.001) (cf. Chua et al, 2014). …”

Section: Resultsmentioning

confidence: 99%

TNFα G308A polymorphism is associated with resilience to sleep deprivation-induced psychomotor vigilance performance impairment in healthy young adults

Satterfield

Wisor

Field

et al. 2015

Brain, Behavior, and Immunity

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“…Much of this knowledge comes from animal models of sleep deprivation (1) and from short-term experimentally induced sleep deprivation in humans, where deficits in cognition, vigilance, memory, mood, behavior, ability to learn, immune function, and general performance (6,24) have been identified. Self-reported short sleep duration in epidemiological studies has also been associated with longterm outcomes such as diabetes (25)(26)(27), obesity, depression (28), hypertension (29), and all-cause mortality (10), with at least some studies showing the elderly being particularly susceptible (30).…”

Section: Short Sleep Durationmentioning

confidence: 99%

An Official American Thoracic Society Statement: The Importance of Healthy Sleep. Recommendations and Future Priorities

Mukherjee

Patel

Kales

et al. 2015

Am J Respir Crit Care Med

220

153

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Rationale: Despite substantial public interest, few recommendations on the promotion of good sleep health exist to educate health care providers and the general public on the importance of sleep for overall health.Objectives: The aim of this American Thoracic Society (ATS) statement is to provide a review of the current scientific literature to assist health care providers, especially pulmonologists and sleep physicians, in making recommendations to patients and the general public about the importance of achieving good quality and adequate quantity of sleep.Methods: ATS members were invited, based on their expertise in sleep medicine, and their conclusions were based on both empirical evidence identified after comprehensive literature review and clinical experience.Main Results: We focus on sleep health in both children and adults, including the impact of occupation on sleep, the public health implications of drowsy driving, and the common sleep disorders of obstructive sleep apnea and insomnia. This ATS statement also delineates gaps in research and knowledge that should be addressed and lead to new focused research priorities to advance knowledge in sleep and sleep health.Conclusions: Good quality and quantity of sleep are essential for good health and overall quality of life; therefore a strong recommendation was made for the implementation of public education programs on the importance of sleep health.

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“…However, in 2013 it was estimated that Americans average 6.8 hours per night and that 40% of Americans average six or less hours per night [2]. Sleep deprived individuals exhibit impairment in several areas such as operating machinery, [3] lack of focus, [4] sustained attention, reaction time, and cognitive processing speed [5]. These impairments contribute to a high degree in loss of work productivity and workplace injury [1,[6][7][8][9][10][11].…”

Section: Introductionmentioning

confidence: 99%

Physical and Psychological Stress and Sleep Efficiency before and after Introducing a New Sleep Surface

Monaghan¹

2015

J Sleep Disord Ther

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Background: It has been long assumed that stress interferes with sleep, but less has been attributed to the converse of poor sleep contributing to stress. Study question:Can an older sleep surface contribute to poor sleep and thus, stress and will a new sleep surface provide better sleep, thus less stress.Methods: Forty-six participants rated physical and psychological signs of stress and sleep efficiency for three weeks while sleeping in their own beds. Following baseline measures participants' beds were replaced by new, unmarked beds and they again rated their stress and sleep efficiency.Results: Average age of participants' bed was 11.27 yrs. Physical and psychological signs of stress were reduced significantly (p<0.01) from pre-to post-assessments. Similarly, sleep efficiency improved significantly (p<0.01) between pre-and post-assessments. Conclusions:Replacing an older mattress that may have lost adequate support and comfort may result in a better night's sleep thereby reducing stress brought on by a lack of sleep. It was suggested that a simple principal step in acquiring better sleep is to consider a new sleep surface rather than to opt for pharmaceuticals to achieve better sleep. ResultsThe survey taken by the participants indicated that the average age of their beds was 11.27 years (SD+4.27 years) with a range between 6 and 18 years, well over the recommended usage (Table 1). All analyses were conducted by controlling for bed age, participants' age, and bed cost. A repeated measures ANOVA analysis of pre-, mid-, and posttest physical stress yielded a significant (p<0.001) difference among means (F=43.67) and the post-hoc tests indicated that significant differences existed between pre-and post-test, between mid-and posttest, but not between pre-and mid-tests (Tables 2 and 3). Citation: Jacobson BH, Monaghan TP (2015) Physical and Psychological Stress and Sleep Efficiency before and after Introducing a New Sleep Surface.

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Sustained Attention Performance during Sleep Deprivation Associates with Instability in Behavior and Physiologic Measures at Baseline

Cited by 68 publications

References 41 publications

TNFα G308A polymorphism is associated with resilience to sleep deprivation-induced psychomotor vigilance performance impairment in healthy young adults

TNFα G308A polymorphism is associated with resilience to sleep deprivation-induced psychomotor vigilance performance impairment in healthy young adults

An Official American Thoracic Society Statement: The Importance of Healthy Sleep. Recommendations and Future Priorities

Physical and Psychological Stress and Sleep Efficiency before and after Introducing a New Sleep Surface

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