A special focus of this chapter is directed into assessing the performance of façades along the service life of the building. Influence of biotic and abiotic factors and their effect on materials physical and aesthetical properties are discussed. Principles of protection by design and their role in building performance during use phase are briefly introduced. Various approaches for the prediction of service life performance are supported with real case study data. Façades directly influence building safety, comfort, and aesthetics. According to Martinez et al. (2015), façades have a role in security, thermal and acoustical insulation, air and water infiltration/mitigation, solar, daylight and glare control as well as in aesthetics. Over time, façade complexity evolved to accommodate a wide range of functionalities. Consequently, proper façade design has become a challenging and demanding task. Flores-Colen and de Brito (2010) listed several difficulties related to the performance of building façades. Those drawbacks are mainly related to poor design of construction details, improper choice or/and application of materials, and inadequate maintenance. To minimize mistakes in façade construction, modern design standards follow current building codes and specifications. However, the choice of proper materials is still challenging. Designers are often not willing to implement novel solutions with improved durability and low maintenance requirements, because they are not confident in their performance. At the same time, regular maintenance of façades is undesired among building owners. Fortunately, biomaterials are continuously improving and becoming more resistant to deterioration. Recent improvements in quality of biomaterials enable contractors to guarantee longer periods without maintenance, as well as to schedule the maintenance in advance. It is commonly accepted that façades require profound maintenance and/or partial renovation/replacement after 20 to 30 years following the construction (Martinez et al. 2015). By predicting service life, it is possible to calculate lifelong construction costs (Gobakken and Lebow 2010). The deterioration intensity of façades depends on