Sustainable release of vancomycin from micro-arc oxidised 3D-printed porous Ti6Al4V for treating methicillin-resistant<i>Staphylococcus aureus</i>bone infection and enhancing osteogenesis in a rabbit tibia osteomyelitis model

Zhang, Teng; Wei, Qingguang; Zhou, Hua; Zhou, Wenhao; Fan, Daoyang; Lin, Xinhong; Jing, Zehao; Cai, Hong; Cheng, Yan; Liu, Xiaoguang; Li, Weishi; Song, Chunli; Tian, Yun; Xu, Nanfang; Zheng, Yufeng; Liu, Zhongjun

doi:10.1039/c9bm01968e

Cited by 40 publications

(48 citation statements)

References 40 publications

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“…This film is known to be antibacterial and thus enhances the biocompatibility and biomimetism of the material (Table 1). [ 96 ] In view of their high mechanical properties, they are often used in load‐bearing sites such as tibiae defects, [ 97,98 ] but also in craniofacial and spine fusion surgery and in chest reconstruction (Figure 1). [ 17,99–107 ] Metals are also used to manufacture hip prosthesis, [ 108 ] shoulder prosthesis and commercial screws used in hand, foot, and ankle bone repair.…”

Section: Synthetic Bone Graft Materialsmentioning

confidence: 99%

“…These techniques are used to print ceramics (inkjet printing, [ 13,75,76,137–141 ] SLS), [ 25,142 ] polymers in powder‐form (SLS, [ 18,50,51,55,67,68 ] inkjet printing), [ 61,143 ] composites (SLS, [ 74 ] inkjet printing), [ 91 ] and metals (SLM, [ 97,99,100,107 ] DMLS, [ 17,20,105,106 ] EBM, Figure 2). [ 98,101–104 ] All types of materials can be printed using a laser since they can all be found in powder form and the laser has sufficient power to fuse all kinds of particles. However, metals cannot be printed by inkjet printing because the liquid binder cannot induce the fusion of metal particles.…”

Section: Additive Manufacturing For Bone Regenerationmentioning

confidence: 99%

“…[ 18,67,78,86–93,117–121,123–134,137–140,146,147 ] Around 32% of the preclinical studies reviewed in Table 2 are conducted in load‐bearing sites. [ 12,53,54,63,64,73,74,82–85,97,98,104,127,135,141 ] This difference may be due to the specific requirement for bone healing in a load‐bearing sites: good mechanical properties of the scaffolds are a prerequisite.…”

Section: Translational Studies On Custom‐made Synthetic Bone Graftsmentioning

confidence: 99%

“…For applications in tibia, femur, or ulna repair using titanium, polymer, or composite scaffolds, the preclinical studies of Table 2 show that large pore sizes of at least 550 µm with a fully interconnected pore structure lead to good results in terms of bone formation. [ 12,53,54,82,83,97,98 ] Moreover, a porosity > 60% leads to better bone ingrowth than lower porosity. [ 73,74,82,83,98 ] Contrary to what is required for dental implants, a slower degradation rate is better for these application sites to provide a sustained mechanical support until full bone regeneration.…”

Section: Translational Studies On Custom‐made Synthetic Bone Graftsmentioning

confidence: 99%

“…[ 12,53,54,82,83,97,98 ] Moreover, a porosity > 60% leads to better bone ingrowth than lower porosity. [ 73,74,82,83,98 ] Contrary to what is required for dental implants, a slower degradation rate is better for these application sites to provide a sustained mechanical support until full bone regeneration. [ 54 ] Thus, the use of PCL is preferred rather than PLGA for example.…”

Section: Translational Studies On Custom‐made Synthetic Bone Graftsmentioning

confidence: 99%

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Additive Manufacturing of Material Scaffolds for Bone Regeneration: Toward Application in the Clinics

Garot

Bettega

Picart

2020

Adv Funct Materials

127

105

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Additive manufacturing (AM) allows the fabrication of customized bone scaffolds in terms of shape, pore size, material type, and mechanical properties. Combined with the possibility to obtain a precise 3D image of the bone defects using computed tomography or magnetic resonance imaging, it is now possible to manufacture implants for patient‐specific bone regeneration. This paper reviews the state‐of‐the‐art of the different materials and AM techniques used for the fabrication of 3D‐printed scaffolds in the field of bone tissue engineering. Their advantages and drawbacks are highlighted. For materials, specific criteria, are extracted from a literature study: biomimetism to native bone, mechanical properties, biodegradability, ability to be imaged (implantation and follow‐up period), histological performances, and sterilization process. AM techniques can be classified in three major categories: extrusion‐based, powder‐based, and vat photopolymerization. Their price, ease of use, and space requirement are analyzed. Different combinations of materials/AM techniques appear to be the most relevant depending on the targeted clinical applications (implantation site, presence of mechanical constraints, temporary or permanent implant). Finally, some barriers impeding the translation to human clinics are identified, notably the sterilization process.

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Section: Synthetic Bone Graft Materialsmentioning

confidence: 99%

Section: Additive Manufacturing For Bone Regenerationmentioning

confidence: 99%

Section: Translational Studies On Custom‐made Synthetic Bone Graftsmentioning

confidence: 99%

Section: Translational Studies On Custom‐made Synthetic Bone Graftsmentioning

confidence: 99%

Section: Translational Studies On Custom‐made Synthetic Bone Graftsmentioning

confidence: 99%

See 3 more Smart Citations

Additive Manufacturing of Material Scaffolds for Bone Regeneration: Toward Application in the Clinics

Garot

Bettega

Picart

2020

Adv Funct Materials

127

105

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Plate-associated localized osteitis in mini-pig by biofilm-forming Methicillin-resistant Staphylococcus aureus (MRSA): establishment of a novel experimental model

Jaekel

Windolf

Sager

et al. 2022

Eur J Trauma Emerg Surg

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Purpose The increasing number of implant-associated infections during trauma and orthopedic surgery caused by biofilm-forming Staphylococcus aureus in combination with an increasing resistance of conventional antibiotics requires new therapeutic strategies. One possibility could be testing for different therapeutic strategies with differently coated plates. Therefore, a clinically realistic model is required. The pig offers the best comparability to the human situation, thus it was chosen for this model. The present study characterizes a novel model of a standardized low-grade acute osteitis with bone defect in the femur in mini-pigs, which is stabilized by a titanium locking plate to enable further studies with various coatings. Methods A bone defect was performed on the femur of 7 Aachen mini-pigs and infected with Methicillin-resistant S. aureus (MRSA ATCC 33592). The defect zone was stabilized with a titanium plate. After 14 days, a plate change, wound debridement and lavage were performed. Finally, after 42 days, the animals were lavaged and debrided again, followed by euthanasia. The fracture healing was evaluated radiologically and histologically. Results A local osteitis with radiologically visible lysis of the bone could be established. The unchanged high Colony-forming Units (CFU) in lavage, the significant differences in Interleukin (IL)-6 in blood compared to lavage and the lack of increase in Alkaline Phosphates (ALP) in serum over the entire observation period show the constant local infection. Conclusion The study shows the successful induction of local osteitis with lysis of the bone and the lack of enzymatic activity to mineralize the bone. Therefore, this standardized mini-pig model can be used in further clinical studies, to investigate various coated implants, bone healing, biofilm formation and immune response in implant-associated osteitis.

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Optimizing vancomycin release from novel carbon fiber-reinforced polymer implants with small holes: periprosthetic joint infection treatment

et al. 2023

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Sustainable release of vancomycin from micro-arc oxidised 3D-printed porous Ti6Al4V for treating methicillin-resistantStaphylococcus aureusbone infection and enhancing osteogenesis in a rabbit tibia osteomyelitis model

Abstract: Sustainable release of vancomycin from micro-arc oxidised 3D-printed porous Ti6A14V for treating MRSA bone infection and enhancing osteogenesis.

Cited by 40 publications

References 40 publications

Additive Manufacturing of Material Scaffolds for Bone Regeneration: Toward Application in the Clinics

Additive Manufacturing of Material Scaffolds for Bone Regeneration: Toward Application in the Clinics

Plate-associated localized osteitis in mini-pig by biofilm-forming Methicillin-resistant Staphylococcus aureus (MRSA): establishment of a novel experimental model

Optimizing vancomycin release from novel carbon fiber-reinforced polymer implants with small holes: periprosthetic joint infection treatment

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