Sustainable antimicrobial effect of silver sulfadiazine-loaded nanosheets on infection in a mouse model of partial-thickness burn injury

Ito, Keisuke; Saito, Akihiro; Fujie, Toshinori; Nishiwaki, K; Miyazaki, Hiromi; Kinoshita, Manabu; Saitoh, Daizoh; Ohtsubo, Shinya; Takeoka, Shinji

doi:10.1016/j.actbio.2015.05.035

Cited by 82 publications

(52 citation statements)

References 31 publications

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“…all of them are hydrophilic, indicating that the Preparation has not changed the characteristics of the material itself. This may be related to the internal hydrophobicity of chitin and the basic structure of external hydrophilic [13,14].…”

Section: Discussionmentioning

confidence: 99%

Nanosilver coated Chitin derived membrane as an Eco-friendly Dressing and Its Effect on Wound Healing

Zhou¹,

Yang²,

Luo³

2017

2017 4th International Materials, Machinery and Civil Engineering Conference (MATMCE 2017)

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Abstract. This study aims to prepare an eco-friendly dressing using Chitin derived membrane with Nanosilver included for anti-bacterial purpose,and also divided into five groups.Group Control was Chitin and Group A was Chitin+dopamine gule (methods for mussel-inspired adhesion of Nanosilver) , respectively, at 0.5mmol/L, 1mmol/L, 2mmol/L (Namely group B, C and D). We found Nanosilver spherical particles formed on chitin dressing. The contact angle test shows that the material was still hydrophilic after processing. Cell staining showed no obvious toxicity in each group.On day 7, the healing rates are 35.2 %, 45.8 %, 56.7 %, 67.9 % and 73.8% in Group Control, A, B, C and D, respectively.The wound healing rate is higher in the C and D groups than these in the other three groups (P <0.05). Similarly, the lengths of the new epithelialm were 618.5 μm, 703.7 μm, 810.2 μm, 879.4 μm and 951.0 μm. in the five groups, respectively. These in group C and D were higher than those in the other three groups (P <0.05).

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Section: Discussionmentioning

confidence: 99%

Nanosilver coated Chitin derived membrane as an Eco-friendly Dressing and Its Effect on Wound Healing

Zhou¹,

Yang²,

Luo³

2017

2017 4th International Materials, Machinery and Civil Engineering Conference (MATMCE 2017)

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“…PLA SSD Partial-thickness burn Reduce the number of MRSA bacteria on the lesion; suppress the inflammatory reaction and enhance the wound healing rate (Ito, Saito et al, 2015).…”

Section: Bc and Bc-ch None Excision Woundmentioning

confidence: 99%

“…Mice Third 92-95 10 10 × 10 mm 2 (Dai, Tegos et al, 2009) Rat Second or third 180 15 2 × 2 cm 2 (Shettigar, Jagannathan et al, 1982) Rat Second NR 10 1 × 1 cm 2 (de Almeida, Cardoso et al, 2013) Pig NR 90 20 5 × 5 cm 2 (Nunes, Rabelo et al, 2016) Mice Partial-thickness 70 (hot water) 4 15 × 15 mm 2 (Ito, Saito et al, 2015) Pig Third 100 30 5 × 5 cm 2 (Boucard, Viton et al, 2007) Rat Second 94 (hot water) 15 r = 1 cm (Alemdaroglu, Degim et al, 2006) NR Third 200 30 NR (Shen, Song et al, 2015) Pig Partial-thickness 100 22 d = 3 cm (Cylandeical) (Roy, Tomblyn et al, 2016) Rat Full-thickness 90 20 ф = 15 mm (circular) (Liu, Huang et al, 2017) Rat Full-thickness 85 20 d = 1.5 cm (rod) (Gupta, Upadhyay et al, 2013) Rat Full-thickness 85 15 NR (Heo, Yang et al, 2013) Rat Second 90 8 d = 3 cm (circular) (Meng, Chen et al, 2009) Rat Second 99 (water steam) 13 20 × 20 mm 2 (square) (Liu, Lin et al, 2012) Rat Second 90 10 2 × 3 cm 2 (Kossovich, Salkovskiy et al, 2010) Rat NR NR 10 250 mm 2 (MH, Saraswathi et al, 2010) NR Partial-thickness burn wound 80 10-12 min 300 mm 2 (Kumar, Khan et al, 2013) NR Full-thickness 100 8 NR (Abdullahi, Amini-Nik et al, 2014) Abbreviations: NR, not reported; R, radius; d, diameter; ф = area.…”

Section: Conclusion and Future Outlookmentioning

confidence: 99%

Current status and future outlook of nano‐based systems for burn wound management

et al. 2019

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Wound healing process is a natural and intricate response of the body to its injuries and includes a well-orchestrated sequence of biochemical and cellular phenomena to restore the integrity of skin and injured tissues. Complex nature and associated complications of burn wounds lead to an incomplete and prolonged recovery of these types of wounds. Among different materials and systems which have been used in treating the wounds, nanotechnology driven therapeutic systems showed a great opportunity to improvement and enhancement of the healing process of different type of wounds. The aim of this study is to provide an overview of the recent studies about the various nanotechnology-based management of burn wounds and the future outlook of these systems in this area. Laboratory and animal models for assessing the efficacy of these systems in burn wound management also discussed. K E Y W O R D S burn wound, laboratory and animal models, multicomposites, nanomedicine, nanotechnologybased systems, nanoparticles, scaffolds

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“…Therefore, in the absence of this skin like swaddle, human body provides excellent medium for the development and propagation of pathogenic microorganisms. Thus, the development of innovative wound and burn dressing advancement is in great demand [12,13] known that the silver and its compounds such as silver sulfadiazine (AgSD) are widely used in most of the skin complications because of their peerless antimicrobial activity [14,15]. But, the AgSD shows cytotoxicity and allergic reactions in clinical studies, which lead to hamper the healing progress of skin [16].…”

Section: Introductionmentioning

confidence: 99%

Improved antimicrobial property and controlled drug release kinetics of silver sulfadiazine loaded ordered mesoporous silica

Jangra

Devi²,

Tomer

et al. 2016

Journal of Asian Ceramic Societies

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a b s t r a c tThe present study deals with the loading of silver sulfadiazine into ordered mesoporous silica material by post-impregnation method and its effect on the in vitro release kinetics and antimicrobial property of the drug. The formulated SBA-15 silica material with rope-like morphology and SBA-15-silver sulfadiazine (SBA-AgSD) were characterized by UV-visible spectrophotometer, small and wide-angle powder X-ray diffraction (PXRD), field emission scanning electron microscope (FESEM) and high resolution transmission electron microscope (HRTEM). Thermo-gravimetric analysis of SBA-AgSD revealed a high loading amount of 52.87%. Nitrogen adsorption-desorption analysis confirmed the drug entrapment into host material by revealing a reduced surface area (214 m 2 /g) and pore diameter (6.7 nm) of the SBA-AgSD. The controlled release of silver sulfadiazine drug from the mesoporous silica to simulated gastric, intestinal and body fluids was evaluated. The Korsmeyer-Peppas model fits the drug release data with the non-Fickian diffusion model and zero order kinetics of SBA-AgSD. The antibacterial performance of the SBA-AgSD was evaluated with respect to Staphylococcus aureus, Bacillus subtilis and Pseudomonas aeruginosa. The controlled drug delivery of the SBA-AgSD revealed improved antibacterial activity, thus endorsing its applicability in effective wound dressing.

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Sustainable antimicrobial effect of silver sulfadiazine-loaded nanosheets on infection in a mouse model of partial-thickness burn injury

Cited by 82 publications

References 31 publications

Nanosilver coated Chitin derived membrane as an Eco-friendly Dressing and Its Effect on Wound Healing

Nanosilver coated Chitin derived membrane as an Eco-friendly Dressing and Its Effect on Wound Healing

Current status and future outlook of nano‐based systems for burn wound management

Improved antimicrobial property and controlled drug release kinetics of silver sulfadiazine loaded ordered mesoporous silica

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