«Suspects» in Etiology of Endemic Nephropathy: Aristolochic Acid versus Mycotoxins

Pepeljnjak, Stjepan; Klarić, Maja Šegvić

doi:10.3390/toxins2061414

Cited by 23 publications

(13 citation statements)

References 57 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Aristolochic acids (AAs), naturally occurring nephrotoxicants and human carcinogens, are associated with the development of a rapidly progressive interstitial nephritis called aristolochic acid nephropathy (AAN) [45], and may also be a cause for the Balkan Endemic Nephropathy (BEN) [46]( Figure 6). AAs are a mixture of structurally related nitrophenanthrene carboxylic acids [47].…”

Section: Aristolochia Speciesmentioning

confidence: 99%

Quality Control of Natural Products by Fingerprinting of Eastern Blotting

Fujii¹,

Tung²,

Uto³

et al. 2016

Pharm Anal Acta

View full text Add to dashboard Cite

Eastern blotting was developed for small molecule compounds which have no affinity of conjugation to membrane instead of western blotting. Crude extracts of medicinal plants were developed by TLC plate followed to be blotted to polyvinylidene fluoride or polyether sulfone membrane by heating. Components on membrane were conjugated with carrier protein resulting in fixing to membrane. Staining was followed to western blotting system using monoclonal antibody (MAb). Four types of natural products, solasodine glycosides, aristrochic acid, glycyrrhizin-liquiritin and ginsenosides were discussed in this review. 1) Solasodine glycosides are selected as an example of staining for almost all solasodine glycosides using the anti-solamargine MAb having wide cross-reactivity. 2) Aristrochic acids possess no capacity of conjugation with membrane and their aqueous solubility is quite poor. To improving them, aristrochic acids should be synthesized for conjugation with carrier protein in order to combine to membrane. 3) Two different types of marker components in licorice, triterpene glycoside; glycyrrhizin and flavonoid glycoside; liquiritin can be detected by double eastern blotting. 4) Ginsenosides are also detected by double eastern blotting and this system might be possible to clear the distribution of ginsenosides in tissue for understanding of pharmacological activity.

show abstract

Section: Aristolochia Speciesmentioning

confidence: 99%

Quality Control of Natural Products by Fingerprinting of Eastern Blotting

Fujii¹,

Tung²,

Uto³

et al. 2016

Pharm Anal Acta

View full text Add to dashboard Cite

show abstract

“…For example, studies conducted in Croatian and Bulgarian endemic nephropathy (EN) areas were focused on the levels of resident exposure to OTA (2,3). Cereals are commonly contaminated with the Fusarium species and therefore often analysed for the presence of Fusarium mycotoxins such as FBs, ZEA, deoxynivalenol (DON), diacetoxiscitpenol (DAS), beauvericin (BEA), or T-2 toxin (4-6), but only a limited number of studies have paid attention to or specifi ed the percentage of co-contaminated samples.…”

Section: Co-occurrence Of Mycotoxins In Foodmentioning

confidence: 99%

Adverse Effects Of Combined Mycotoxins / Štetni Učinci Kombiniranih Mikotoksina

Klarić

2012

Archives of Industrial Hygiene and Toxicology

Self Cite

View full text Add to dashboard Cite

This article brings an overview of mycotoxin co-occurrence in foods in Croatia and neighbouring countries and experimental data from mycotoxin interaction studies involving Fusarium toxins, ochratoxin A (OTA), and afl atoxin B 1 (AFB 1 ). Only a few studies of combined mycotoxin toxicity have employed a mathematical/ statistical design, while others have used common statistics in order to compare the effects of mycotoxin mixtures with effects of single toxins. So far, most studies have observed additive or synergistic effects, suggesting that these mixtures pose a signifi cant threat to human and animal health.

show abstract

“…Aristolochic acids (AAs) are naturally occurring nephrotoxicants and human carcinogens that are associated with the development of a rapidly progressive interstitial nephritis called aristolochic acid nephropathy (AAN) (Debelle et al, 2008), and they may also be a cause of Balkan endemic nephropathy (BEN) (Pepeljnjak and Klaric, 2010). Aristolochic acids are a mixture of structurally related nitrophenanthrene carboxylic acids (Kumar et al, 2003).…”

Section: Introductionmentioning

confidence: 99%