Suspected-target pesticide screening using gas chromatography–quadrupole time-of-flight mass spectrometry with high resolution deconvolution and retention index/mass spectrum library

Evaluation of gas chromatography – electron ionization – full scan high resolution Orbitrap mass spectrometry for pesticide residue analysis

“…The scan speeds of 3.8-18 scans/s were lower than can be obtained with GC-EI-TOF-MS systems (up to 50 [23] or even 200 scans/s [28]). They are, however, in the same range that are actually applied in residue applications using TOF-MS (5 scans/s) since scan speeds of 10 scans/s and higher were reported to result in loss of signal, sensitivity and spectral fidelity [23].…”

“…They are, however, in the same range that are actually applied in residue applications using TOF-MS (5 scans/s) since scan speeds of 10 scans/s and higher were reported to result in loss of signal, sensitivity and spectral fidelity [23].…”

“…In 2012 a GC-Q-TOF-MS instrument with both EI and chemical ionization (CI) became available. The resolving power improved to 12,500 but saturation (affecting mass accuracy and linear range) was still an issue, which need to be dealt with by post-acquisition workarounds [22][23][24][25][26].…”

Chromatographic peak reconstruction algorithm to improve qualitative and quantitative analysis of trace pesticide residues

“…To date, gas chromatography/time‐of‐flight mass spectrometry (GC/TOFMS) is a powerful technique for volatile and semi‐volatile pesticide analyses due to the remarkable separation power of the GC and the higher resolution of the TOFMS . TOFMS can provide the high mass accuracy of full‐scan spectra at a fast scan rate, even for pesticides at the trace level in a complex matrix.…”

“…[11][12][13] To date, gas chromatography/time-of-flight mass spectrometry (GC/TOFMS) is a powerful technique for volatile and semi-volatile pesticide analyses due to the remarkable separation power of the GC and the higher resolution of the TOFMS. [14][15][16] TOFMS can provide the high mass accuracy of full-scan spectra at a fast scan rate, [17][18][19][20] even for pesticides at the trace level in a complex matrix. However, identifying all of the underlying signals in a complex sample remains challenging as the signals of interest may be obscured by interfering signals.…”