Evaluation of gas chromatography – electron ionization – full scan high resolution Orbitrap mass spectrometry for pesticide residue analysis

Mol, Hans; Tienstra, Marc; Zomer, Paul

doi:10.1016/j.aca.2016.06.017

Cited by 87 publications

(37 citation statements)

References 46 publications

(58 reference statements)

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“…The Q Exactive GC and Exactive GC instruments opened a new chapter in the long history of marriage between gas chromatography and MS. These systems combined HR/AM with sensitivity and linearity that even in the full mass range mode was at par with triple quadrupoles operated in SIM mode.…”

Section: Orbitrap Msmentioning

confidence: 99%

Ion traps in modern mass spectrometry

Nolting

Malek

Makarov

2017

Mass Spectrometry Reviews

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This review is devoted to trapping mass spectrometry wherein ions are confined by electromagnetic fields for prolonged periods of time within limited volume, with mass measurement taking place within the same volume. Three major types of trapping mass spectrometers are discussed, specifically radiofrequency ion trap, Fourier transform ion cyclotron resonance and Orbitrap. While these three branches are intricately interwoven with each other over their recent history, they also differ greatly in their fundamentals, roots and historical origin. This diversity is reflected also in the difference of viewpoints from which each of these directions is addressed in this review. Following the theme of the issue, we focus on developments mainly associated with the country of Germany but, at the same time, we use this review as an illustration of the rapidly increasing globalization of science and expanding multi-national collaborations.

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Section: Orbitrap Msmentioning

confidence: 99%

Ion traps in modern mass spectrometry

Nolting

Malek

Makarov

2017

Mass Spectrometry Reviews

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“…GC‐EI‐hybrid quadrupole‐Orbitrap MS is a new technology that became commercially available for the first time in 2015 . GC provides high separation efficiency and consequently narrow chromatographic peak widths of approximately 3–6 s. The Orbitrap mass analyzer can operate in high‐resolution full‐scan mode up to (FWHM 120 000 at m/z 200) and with mass accuracy lower than 1 ppm.…”

Section: Introductionmentioning

confidence: 99%

Non‐targeted acquisition strategy for screening doping compounds based on GC‐EI‐hybrid quadrupole‐Orbitrap mass spectrometry: A focus on exogenous anabolic steroids

Cavalcanti

Rodrigues

Santos

et al. 2017

Drug Testing and Analysis

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This is a first look at a non-targeted screening method based on Orbitrap gas chromatography-mass spectrometry (GC-MS) technology for a large number of banned compounds in sports found in urine, including exogenous anabolic steroids, β-agonists, narcotics, stimulants, hormone modulators, and diuretics. A simple sample preparation was processed in four steps: an enzymatic hydrolysis, liquid-liquid extraction, evaporation, and trimethylsilylation. All compounds were able to meet the World Anti-Doping Agency's sensitivity criteria with mass accuracies less than 1 ppm and with sufficient points across the peak by running the Orbitrap GC-MS in full-scan mode. In addition, we discuss our initial findings of using a full-scan selected ion monitoring-tandem mass spectrometry (SIM-MS/MS) approach as a way to obtain lower detection limits and reach desirable selectivity for some exogenous anabolic steroids.

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“…Similar peak areas were observed for resolution of 15, 30, and 60 k, and slightly lower at 120 k. The pesticides were identified using nominal mass resolution National Institute of Standards and Technology library. The LOQ for all studied pesticides (except of dimethomorph in orange) reached 1 μg/kg, which is ten times lower than limits required by official EU legislation (SANTE/11945/2015) . The study was later broadened to 210 pesticides in tomato, apple, leek, and orange.…”

Section: Food Analysismentioning

confidence: 82%

Recent applications of gas chromatography with high‐resolution mass spectrometry

S̆pánik¹,

Machyňáková²

2017

J of Separation Science

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Gas chromatography coupled to high-resolution mass spectrometry is a powerful analytical method that combines excellent separation power of gas chromatography with improved identification based on an accurate mass measurement. These features designate gas chromatography with high-resolution mass spectrometry as the first choice for identification and structure elucidation of unknown volatile and semivolatile organic compounds. Gas chromatography with high-resolution mass spectrometry quantitative analyses was previously focused on the determination of dioxins and related compounds using magnetic sector type analyzers, a standing requirement of many international standards. The introduction of a quadrupole high-resolution time-of-flight mass analyzer broadened interest in this method and novel applications were developed, especially for multi-target screening purposes. This review is focused on the development and the most interesting applications of gas chromatography coupled to high-resolution mass spectrometry towards analysis of environmental matrices, biological fluids, and food safety since 2010. The main attention is paid to various approaches and applications of gas chromatography coupled to high-resolution mass spectrometry for non-target screening to identify contaminants and to characterize the chemical composition of environmental, food, and biological samples. The most interesting quantitative applications, where a significant contribution of gas chromatography with high-resolution mass spectrometry over the currently used methods is expected, will be discussed as well. K E Y W O R D Saccurate mass measurement, environmental analysis, gas chromatography, high-resolution mass spectrometry, pesticide residues

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Evaluation of gas chromatography – electron ionization – full scan high resolution Orbitrap mass spectrometry for pesticide residue analysis

Cited by 87 publications

References 46 publications

Ion traps in modern mass spectrometry

Ion traps in modern mass spectrometry

Non‐targeted acquisition strategy for screening doping compounds based on GC‐EI‐hybrid quadrupole‐Orbitrap mass spectrometry: A focus on exogenous anabolic steroids

Recent applications of gas chromatography with high‐resolution mass spectrometry

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