Susceptibility-weighted imaging in grading brain astrocytomas

Li, Chuanting; Ai, Bin; Li, Yan; Qi, Hengtao; Wu, Lijian

doi:10.1016/j.ejrad.2009.08.003

Cited by 59 publications

(54 citation statements)

References 10 publications

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“…The amount of ferritin and transferrin receptors has been shown to correlate with tumor grade. [2,3] The purpose of our study was to evaluate the value of SWI in grading cerebral astrocytomas and compare the relative value of SWI and conventional sequences.…”

Section: Introductionmentioning

confidence: 99%

Susceptibility-weighted imaging: The value in cerebral astrocytomas grading

et al. 2013

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Section: Introductionmentioning

confidence: 99%

Susceptibility-weighted imaging: The value in cerebral astrocytomas grading

et al. 2013

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“…SW images can also be used to estimate other tumors. Previous studies have described that it is possible to rank the grade of malignancy of astrocytomas with the help of ITSS and that highgrade and low-grade astrocytomas can be discriminated with SW images with a higher sensitivity compared to conventional imaging techniques [17,18]. However, in the study of Kim et al SW images did not help with the differentiation of every intracerebral mass lesion.…”

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confidence: 93%

Glioblastomas vs. Lymphomas: More Diagnostic Certainty by Using Susceptibility-Weighted Imaging (SWI)

Peters

Knöß²,

Wodarg³

et al. 2012

Fortschr Röntgenstr

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“…4 and 5). Small vessels within low-grade gliomas, such as astrocytoma, can be depicted with SWI, 63 and complex tumor vasculature can be found in high-grade gliomas, such as glioblastoma multiforme (GBM). 25 In each case, the additional information helps in tumor grading, 25,63 which can support neurosurgeons in diagnosis and therapeutic management.…”

Section: Detecting and Diagnosing Brain Tumorsmentioning

confidence: 99%

“…Numerous studies have shown that SWI is more sensitive than conventional MRI, including T1, 37,63,92 contrast-enhanced T1, 63,92,117 T2, 63,92,98 T2*, 65,117 FLAIR, 63,92 PD-weighted, 92 and diffusion-weighted imaging (DWI) 92 in detecting vasculature, internal architecture, or hemorrhage in tumors (Figs. 4 and 5).…”

Section: Detecting and Diagnosing Brain Tumorsmentioning

confidence: 99%

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Magnetic resonance susceptibility weighted imaging in neurosurgery: current applications and future perspectives

Ieva¹,

Lam²,

Alcaide‐Leon

et al. 2015

JNS

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T he initial development of MR venography by Reichenbach et al. 90 laid the foundation for Haacke et al. 42 to apply the principles of MR venography in conventional MRI for broader usage in clinical and research settings. By utilizing magnitude and phase information, both of which are normally acquired from conventional MRI data, susceptibility weighted imaging (SWI) has an enhanced ability to detect microhemorrhages 4,12,26 and microvasculature. 26,27,41,92 It is a highly sensitive imaging modality able to depict magnetic substances, such as deoxygenated hemoglobin, with high contrast 42 and to help investigate neurological diseases, 82 grade tumors, 25,63 and assist in determining treatment or prognosis. 18,26,37,70,71,115 Over the past years, the SWI technique has found applications in the different fields of neurosurgery, namely neurooncology, vascular neurosurgery, neurotraumatolabbreviatioNs AVM = arteriovenous malformation; CCM = cerebral cavernous malformation; CMB = cerebral microbleed; CVS = cortical vessel sign; DAI = diffuse axonal injury; DBS = deep brain stimulation; DWI = diffusion-weighted imaging; GBM = glioblastoma multiforme; GCS = Glasgow Coma Scale; GPe = external globus pallidus; GPi = internal GP; GRE = gradient-recalled echo; ITSS = intratumoral susceptibility signal; mIP = minimum intensity projection; MRA = MR angiography; MS = multiple sclerosis; PD = proton density; PQ = percentagewise quantification; PWI = perfusion-weighted imaging; SN = substantia nigra; STN = subthalamic nucleus; SWI = susceptibility weighted imaging; TBI = traumatic brain injury; VM = vascular malformation. Susceptibility weighted imaging (SWI) is a relatively new imaging technique. Its high sensitivity to hemorrhagic components and ability to depict microvasculature by means of susceptibility effects within the veins allow for the accurate detection, grading, and monitoring of brain tumors. This imaging modality can also detect changes in blood flow to monitor stroke recovery and reveal specific subtypes of vascular malformations. In addition, small punctate lesions can be demonstrated with SWI, suggesting diffuse axonal injury, and the location of these lesions can help predict neurological outcome in patients. This imaging technique is also beneficial for applications in functional neurosurgery given its ability to clearly depict and differentiate deep midbrain nuclei and close submillimeter veins, both of which are necessary for presurgical planning of deep brain stimulation. By exploiting the magnetic susceptibilities of substances within the body, such as deoxyhemoglobin, calcium, and iron, SWI can clearly visualize the vasculature and hemorrhagic components even without the use of contrast agents. The high sensitivity of SWI relative to other imaging techniques in showing tumor vasculature and microhemorrhages suggests that it is an effective imaging modality that provides additional information not shown using conventional MRI. Despite SWI's clinical advantages, its implementation in MRI protocols is st...

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Susceptibility-weighted imaging in grading brain astrocytomas

Cited by 59 publications

References 10 publications

Susceptibility-weighted imaging: The value in cerebral astrocytomas grading

Susceptibility-weighted imaging: The value in cerebral astrocytomas grading

Glioblastomas vs. Lymphomas: More Diagnostic Certainty by Using Susceptibility-Weighted Imaging (SWI)

Magnetic resonance susceptibility weighted imaging in neurosurgery: current applications and future perspectives

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