Susceptibility of respiratory isolates of Streptococcus pneumoniae isolated from children hospitalized in the Clinical center Nis

Abstract

Amoxicillin could be the therapy of choice in pediatric practice. The macrolides should not be recommended for the empirical therapy of pneumococcal respiratory tract infection in our local area.

The prevalence of resistance to macrolides and lincosamides among community- and hospital- acquired staphylococci and streptococci isolates in southeast Serbia

“…In our region, cMLSb phenotype was the most prevalent (38.2%) of all S. pneumoniae isolates from outpatient samples, whereas the M/MSb (33.3%) was dominant among hospital-acquired isolates. Different from our findings, authors from the Nišava district and central and northern parts of Serbia found that the dominant MLS resistance phenotype was cMLSb among hospital isolates of S. pneumoniae, but authors from Italy yielded results similar to our findings [22,23,25,26].…”

“…Only a small percentage of our S. pneumoniae isolates showed resistance to penicillin (9.1%, 5/5 community-and 11.1%, 1/9 hospital-acquired), while Mladenović-Antić et al [21] discovered higher resistance to penicillin (27%) in hospital-acquired pneumococci isolates in the first decade of this century in the Nišava region, Serbia. In our region, we discovered a very high resistance rate to erythromycin in S. pneumoniae (63.6%, 35/55 community-and 77.8%, 7/9 hospital-acquired isolates), which was in accordance with findings by Dinić et al [22] (78.4% and 65.6%, respectively). However, Hadnađev et al [23] and Mijač et al [4] found lower rate of resistance to erythromycin in S. pneumoniae (36% and 45%, respectively) in their studies in Serbia.…”

“…Wide intercountry variations in the emergence of macrolide-resistant S. pneumoniae were recorded across Europe, with prevalence ranging from 0% to 74% in a period from 2012 to 2015 [3]. Also, a very high resistance rate to clindamycin among our community-associated strains of S. pneumoniae (38.2%, 21/55) was detected, while neither one of our S. pneumoniae isolates showed resistance to ciprofloxacin, which was similar to other researches from Serbia [22,24].…”