Results from the Survey of Antibiotic Resistance (SOAR) 2014–16 in Bulgaria, Romania, Serbia and Croatia

Torumkuney, D; Nica, Maria; Nistor, Irina; Vatcheva-Dobrevska, Rossitza; Petrović, Vladimir; Stoica, Alexandru; Hanicar, B; Antic, Dj; Morrissey, Ian

doi:10.1093/jac/dky066

Cited by 15 publications

(13 citation statements)

References 18 publications

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“…15 Among H. influenzae, the b-lactamase rate in Greece was 15.4%, similar to the findings in the 2009-12 study in Greece (13.8%), 10 but significantly higher than the rate seen in neighbouring Turkey (6.8%) from 2011 to 2013 (P " 0.049), 16 and higher than the rate of 8.4% in the nearby countries of Bulgaria, Croatia, Romania and Serbia in 2014-16. 17 Nevertheless, susceptibility of H. influenzae was higher in Greece than for S. pneumoniae, with amoxicillin/clavulanic acid, ceftriaxone, cefuroxime and the fluoroquinolones exceeding 95% susceptibility by CLSI criteria. Azithromycin susceptibility was seen in 94.2% of isolates by CLSI breakpoints, but clarithromycin susceptibility was lower (61.5%), and both macrolides showed very poor susceptibility (,5%) by PK/ PD and EUCAST criteria.…”

Section: V40mentioning

confidence: 97%

Results from the Survey of Antibiotic Resistance (SOAR) 2014–16 in Greece

Torumkuney

Papaparaskevas

Morrissey³

2018

Journal of Antimicrobial Chemotherapy

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Objectives: To determine antimicrobial susceptibility in isolates of Streptococcus pneumoniae and Haemophilus influenzae collected in 2014-16 from patients with community-acquired respiratory tract infections in Greece.Methods: MICs were determined by CLSI broth microdilution and susceptibility assessed using CLSI, EUCAST and pharmacokinetic/pharmacodynamic (PK/PD) breakpoints.Results: A total of 99 S. pneumoniae and 52 H. influenzae isolates were collected. Overall, 36.4% of S. pneumoniae were penicillin susceptible by CLSI oral/EUCAST and 88.9% by CLSI intravenous (iv) breakpoints. All were fluoroquinolone susceptible with 94% of isolates also susceptible to amoxicillin, amoxicillin/clavulanic acid and ceftriaxone by CLSI and PK/PD breakpoints. Trimethoprim/sulfamethoxazole, cefuroxime, cefaclor and macrolides were less active, with rates of susceptibility of 83.8%, 69.7%, 50.5% and 49.5%, respectively, by CLSI. Generally susceptibility was the same or slightly lower by EUCAST, but the cefaclor difference was much greater. Among H. influenzae, 15.4% of isolates were b-lactamase positive. Susceptibility to amoxicillin/clavulanic acid, ceftriaxone, cefuroxime and the fluoroquinolones was seen in .95% of isolates by CLSI criteria. Susceptibility to azithromycin was seen in 94.2% of isolates using CLSI breakpoints, but clarithromycin susceptibility was lower (61.5%). However, susceptibility to both macrolides was seen in ,5% of isolates by PK/PD and EUCAST criteria. Susceptibility to trimethoprim/sulfamethoxazole was seen in 71.2% of isolates.Conclusions: Owing to the high prevalence of macrolide resistance among S. pneumoniae and the reduced activity of clarithromycin against H. influenzae, it appears that these agents are not appropriate as monotherapy for community-acquired pneumonia in Greece. Amoxicillin/clavulanic acid, on the other hand, maintained excellent in vitro activity and, as opposed to the similarly effective fluoroquinolones, is safe to use in paediatric patients.

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Section: V40mentioning

confidence: 97%

Results from the Survey of Antibiotic Resistance (SOAR) 2014–16 in Greece

Torumkuney

Papaparaskevas

Morrissey³

2018

Journal of Antimicrobial Chemotherapy

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“…По данным международного исследования SOAR (2014-2016 гг. ), уровень чувствительности к пенициллину в Чехии составил 99,5% [9], в Греции -88,9% [10], в Болгарии -86,6% [11], в Словакии -54,2% [12], в Румынии -22,2% [11], доля чувствительных к пенициллину штаммов в России составила 67% [13].…”

Section: Discussionunclassified

Antimicrobial resistance of clinical Streptococcus pneumoniae isolates in Russia: the results of multicenter epidemiological study «PEHASus 2014–2017»

Иванчик¹,

Chagaryan²,

Сухорукова³

et al. 2019

CMAC

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“…S. pneumoniae'nın antibiyotiklere direnç durumunun bilinmesi, tedaviye yön göstericidir. (12)(13)(14)(15) .…”

Section: Discussionunclassified

“…Ülkemizde olduğu gibi Avrupa ve Amerika'da S. pneumoniae izolatlarında makrolid direnç oranı dramatik olarak artışını sürdürmektedir (12)(13)(14)(15)19,20) . Ülkemizde önceki yıllarda yapılan araştırmalarda eritromisine direnç solunum yolu izolatlarında %9.1, %17.3 ve %37.5 olarak bildirilmiştir (21)(22)(23) .…”

Section: Discussionunclassified

“…Florokinolon grubu antibiyotiklerden moksifloksasin ve levofloksasine bu araştırmada direnç saptanmamıştır. SOAR 2014-2016 yılları arasında yapılan surveyans çalışma sonuçlarına göre Rusya, Bulgaristan, Yunanistan'da florokinolon direnci belirlenmemiştir (12)(13)(14) , Çek Cumhuriyeti'nde ise moksiflokasin ve levofloksasine direnç %0.5 olarak bulunmuştur (15) . Türkiye'de S. pneumoniae izolatlarında, florokinolon direnci bazı çalışmalarda hiç belirlenemezken, bazı çalışmalarda ise oldukça düşük oranlarda (%1.2) bildirilmiştir (17,(24)(25)(26) .…”

Section: Discussionunclassified

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Serotype Distribution and Antibiotic Susceptibility Patterns of Respiratory Isolates of Streptococcus pneumoniae from Hacettepe University Adult Hospital

Altun¹,

Sancak²,

Gür³

2018

TMCD

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Streptococcus pneumoniae'ya bağlı solunum yolu enfeksiyonlarında tedavi, çoğunlukla ampiriktir ve kullanılacak antibiyotiğe toplumdaki direnç oranları göz önüne alınarak karar verilmektedir. Antibiyotik direnci belirli serotiplerde daha sık olarak ortaya çıkmaktadır. Kullanılan aşı türüne göre klinikten izole edilen serotipler ve buna bağlı olarak antibiyotiklere direnç sıklıkları değişiklik gösterebildiğinden, S. pneumoniae'nın klinik izolatlarında antibiyotik direncinin sürekli izlenmesi önemlidir. Bu çalışmanın amacı, 2017 yılında Hacettepe Üniversitesi Yetişkin Hastanesi'ne başvuran erişkin hastaların solunum yolu örneklerinden izole edilmiş olan S. pneumoniae izolatlarının serotiplerini ve çeşitli antibiyotiklere direnç durumunu belirlemektir. Gereç ve Yöntem: Streptococcus pneumoniae izolatları (n=52) 2017 yılında bronkoalveolar lavaj (BAL) (n=4), derin trakeal aspirat (DTA) (n=9) ve balgamdan (n=39), izole edilmiştir. Lateks aglütünasyonu ile 14 serumlu Pneumotest-Latex Kit (Statens Serum Institut, Danimarka) kullanılarak serogruplar, faktör antiserumlar ile serotipleri belirlenmiştir. Penisilin, sefuroksim, seftriakson, vankomisin, moksifloksasin, levofloksasin, meropenem, eritromisin ve klindamisin duyarlılıkları gradient test (Liofilchem ® İtalya)) ile EUCAST standartlarına göre çalışılmıştır.

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Results from the Survey of Antibiotic Resistance (SOAR) 2014–16 in Bulgaria, Romania, Serbia and Croatia

Cited by 15 publications

References 18 publications

Results from the Survey of Antibiotic Resistance (SOAR) 2014–16 in Greece

Results from the Survey of Antibiotic Resistance (SOAR) 2014–16 in Greece

Antimicrobial resistance of clinical Streptococcus pneumoniae isolates in Russia: the results of multicenter epidemiological study «PEHASus 2014–2017»

Serotype Distribution and Antibiotic Susceptibility Patterns of Respiratory Isolates of Streptococcus pneumoniae from Hacettepe University Adult Hospital

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