Susceptibility of high-risk human papillomavirus type 16 to clinical disinfectants

Meyers, Jordan M.; Ryndock, Eric J.; Conway, Michael J.; Meyers, Craig; Robison, Richard A.

doi:10.1093/jac/dku006

Cited by 65 publications

(114 citation statements)

References 14 publications

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“…A recent study has also shown that native human papillomavirus 16 is highly resistant to glutaraldehyde and ortho-phthalaldehyde. 10 Given that 80.5% of post-glutaraldehyde handle samples were contaminated with nonfastidious organisms, it seems likely that fastidious pathogens, viruses, or parasites might also be isolated if a sufficiently large sample size and methods appropriate for detecting these organisms were used. In addition to the automated device tested here, other disinfection methods may also be suitable for disinfecting transducer handles.…”

Section: Discussionmentioning

confidence: 99%

Reducing Transmission Risk Through High-Level Disinfection of Transvaginal Ultrasound Transducer Handles

Ngu¹,

McNally

Patel³

et al. 2015

Infect. Control Hosp. Epidemiol.

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Intracavity ultrasound transducer handles are not routinely immersed in liquid high-level disinfectants. We show that residual bacteria, including pathogens, persist on more than 80% of handles that are not disinfected, whereas use of an automated device reduces contamination to background levels. Clinical staff should consider the need for handle disinfection.Infect Control Hosp Epidemiol 2015;36(5): [581][582][583][584] Ultrasound transducers that contact broken skin or mucous membranes are considered semicritical devices and should undergo high-level disinfection (HLD) between patients. 1 Studies have shown residual contamination on ultrasound transducers when HLD is not performed 2,3 and cases of hepatitis B and C infection have been reported where transmission was thought to have been caused by improper reprocessing of ultrasound transducers. 4,5 HLD methods that involve soaking ultrasound transducers in liquid chemicals, such as glutaraldehyde or ortho-phthalaldehyde, do not typically disinfect the handle. Some major manufacturers specifically advise against submersion of the handle owing to the transducer not being fully sealed. There are no clear recommendations on whether transducer handles should be disinfected, nor is there any consensus on the risk that contaminated transducer handles might pose to patients.Although full immersion of transducers in liquid is not generally possible, approaches that allow the HLD of the entire transducer are now available. This study surveyed the residual contamination on transducer handles when not disinfected (routine soaking method) and also assessed the efficacy of an automated disinfection device capable of disinfecting both heads and handles of ultrasound transducers. methodsThis study was a prospective, bi-centric, cross-sectional study, performed at an ultrasound clinic and public hospital. No patients were excluded and no patient data were collected so the study did not require ethics approval. Following routine ultrasound procedures, all transducers were cleaned with detergent and water and were dried with paper towels. Handle samples were then collected from 2 study groups after the handles were subjected to different disinfection methods. Groups were sampled sequentially in randomized order.The first group of transducers (hereafter referred to as "glutaraldehyde disinfection of head only" [GDHO]) underwent reprocessing according to the existing protocol at the clinic where the head of the transducer was soaked in a 2.4% solution of glutaraldehyde for 20 minutes at room temperature. Transducer handles were not disinfected (per normal practice).The second group of transducers (hereafter referred to as "automated disinfection of head and handle" [ADHH]) were subjected to HLD with an automated disinfection system that disinfects the entire transducer including the handle (trophon EPR; Nanosonics). The device was operated according to the manufacturer's instructions for use.Matched control samples (shams) were collected to quantify contamination occurring during...

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Section: Discussionmentioning

confidence: 99%

Reducing Transmission Risk Through High-Level Disinfection of Transvaginal Ultrasound Transducer Handles

Ngu¹,

McNally

Patel³

et al. 2015

Infect. Control Hosp. Epidemiol.

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“…Using HPV16 virions, the susceptibility to 11 common clinical disinfectants was tested [28]. This study produced some interesting findings.…”

Section: Hpv and Disinfectantsmentioning

confidence: 97%

“…Non-enveloped viruses are notoriously hard to neutralize, but GTA has been shown to be effective against some including adenoviruses, parvoviruses, calciviruses and many enteroviruses [29][30][31]. HPV also showed resistance to ortho-phthaladehyde (OPA), a new alternative to GTA [28]. HPV was found to be sensitive to hypochlorite and to a para-acetic acid-Silver-based disinfectant [28].…”

Section: Hpv and Disinfectantsmentioning

confidence: 99%

See 1 more Smart Citation

A risk for non-sexual transmission of human papillomavirus?

Ryndock

Meyers

2014

Expert Review of Anti-infective Therapy

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Human papillomaviruses (HPVs) are estimated to be the most common sexually transmitted virus in humans. The virus is of great interest as it is the etiological agent of cervical cancer. Sexual transmission of HPV is generally accepted, however, non-sexual transmission of the virus is often debated. Here, we review the evidence from basic research and clinical studies that show HPV can survive well outside of its host to potentially be transmitted by non-sexual means. In doing so, we hope to discover problems in current prevention practices and show a need for better disinfectants to combat the spread of HPV.

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“…What little is known about HPV resistance to virucides derives from studies using recombinant particles, or from a hospital study on potentially infected equipment . Meyers et al, (2014) tested the susceptibility of HPV16 virions to 11 common clinical disinfectants: 70% and 95% ethanol and isopropanol, 2.4% and 3.4% GTA (glutaraldehyde), 0.55% OPA (orthophthaladehyde), a triple phenolic, a 0.25% and 1.2% PAAsilver-based disinfectant and 0.525% hypochlorite). Results showed that commonly used clinical disinfectants, including those used in medical and dental healthcare facilities, have no effect on HPV16 infectivity.…”

Section: Disinfectionmentioning

confidence: 99%

Papillomavirus

Rosa¹

2019

Water and Sanitation for the 21st Century: Health and Microbiological Aspects of Excreta and Wastewater Management (Global Wate

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Susceptibility of high-risk human papillomavirus type 16 to clinical disinfectants

Cited by 65 publications

References 14 publications

Reducing Transmission Risk Through High-Level Disinfection of Transvaginal Ultrasound Transducer Handles

Reducing Transmission Risk Through High-Level Disinfection of Transvaginal Ultrasound Transducer Handles

A risk for non-sexual transmission of human papillomavirus?

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