Papillomavirus

Rosa, Giuseppina La

doi:10.14321/waterpathogens.17

Cited by 4 publications

(3 citation statements)

References 27 publications

(40 reference statements)

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“…Lastly, the waterborne transmission of HPV has never been proven, even though we know that HPV 16 remains infectious for seven days on wet surfaces [ 43 , 44 , 45 ], and HPV samples have been detected in raw sewage and sewage sludge [ 46 , 47 , 48 , 49 ]. HPV was detected in 50% of samples of domestic bathing water [ 50 ].…”

Section: Transmissionmentioning

confidence: 99%

Human Papillomavirus Epidemiology and Prevention: Is There Still a Gender Gap?

et al. 2023

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Background and aim: Human papillomavirus (HPV) is sexually transmitted, one of the three most common sexually transmitted infections (STIs) in both males and females, and the most common viral STI. A crucial public health strategy to protect people against HPV is vaccination, which has shown its effectiveness in preventing HPV-related diseases. Presently, three types of vaccines are available (bivalent, quadrivalent, and nonvalent), and they all target the two most oncogenic virus genotypes (HPV 16 and 18). In recent years, the need to implement vaccination programmes that include all genders has been discussed in order to achieve herd immunity against HPV. To date, only a few countries have included young males in their vaccination programmes. Thus, our objective with this review is to provide an overview of the epidemiology of HPV and HPV prevention strategies and report the latest findings from the scientific literature.

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Section: Transmissionmentioning

confidence: 99%

Human Papillomavirus Epidemiology and Prevention: Is There Still a Gender Gap?

et al. 2023

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“…Lastly, waterborne transmission has never been proven, even though we know that HPV type 16 remains infectious for seven days on wet surfaces [43][44][45], and HPV samples have been detected in raw sewage and sewage sludge [46][47][48][49]. HPV was detected in 50% of the samples of domestic bathing water [50].…”

Section: Transmissionmentioning

confidence: 99%

Human Papillomavirus Epidemiology and Prevention: Is There Still a Gender Gap?

Milano¹,

Guarducci²,

Nante³

et al. 2023

Preprint

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Background and aim: Human Papillomavirus (HPV) is sexually transmitted, one of the three most common sexually transmitted infections (STIs) in both males and females, and the most common viral STI. A crucial public health strategy to protect people against HPV is through vaccination, which has shown its effectiveness in preventing HPV related diseases. Presently three types of vaccines are available (bivalent, quadrivalent, and nonavalent) and they all target at least the two most oncogenic virus genotypes (HPV 16, 18). In the past few years, the need to implement vaccination programmes that include all genders has been discussed in order to achieve herd immunity against HPV. To date, only a few countries have included young males in their vaccination programmes, so we aim through this review to provide an overview of the epidemiology of HPV and prevention strategies to prevent it, reporting the latest findings from the scientific literature.

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“…On the other hand, the spread of HPVs should not be surprising, since studies on water environments demonstrated the presence of HR-HPVs in urban wastewater, river water, swimming pool waters, and spas [27,28]. For these reasons, HPVs have been included among the excreted pathogens potentially dangerous for human health by the Global Water Pathogen Project () [29].…”

Section: Hpv-related Tumorsmentioning

confidence: 99%

Anti-Cancer Vaccine for HPV-Associated Neoplasms: Focus on a Therapeutic HPV Vaccine Based on a Novel Tumor Antigen Delivery Method Using Endogenously Engineered Exosomes

Bonito

Accardi

Galati

et al. 2019

Cancers

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Some human papillomavirus (HPV) genotypes are universally recognized as major etiological agents not only of ano-genital tumors but also of head and neck cancers, which show increasing incidence. The evaluation of current and future therapeutic approaches against HPV-induced tumors is a global health priority, despite an effective prophylactic vaccine against 7 of the 12 genotypes involved in the etiology of tumors being currently available. In this review, we present the main anti-HPV therapeutic approaches in clinical experimentation, with a focus on a novel tumor antigen delivery method using engineered exosomes, that we recently developed. Our system allows the induction of an efficient unrestricted cytotoxic T lymphocyte (CTL) immune response against the HPV16-E7 tumor-associated antigen, with the formation of endogenously engineered exosomes, i.e., nanovesicles spontaneously released by all cell types. Immunogenic exosomes are uploaded with HPV16-E7 due to the fusion with a unique exosome-anchoring protein referred to as Nefmut. Intramuscular injection of a DNA vector expressing the fusion protein generates exosomes sufficiently immunogenic to elicit a potent anti-16E7 CTL immune response. The approach is described here and the advantages over other existing methodologies are reported.

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Papillomavirus

Cited by 4 publications

References 27 publications

Human Papillomavirus Epidemiology and Prevention: Is There Still a Gender Gap?

Human Papillomavirus Epidemiology and Prevention: Is There Still a Gender Gap?

Human Papillomavirus Epidemiology and Prevention: Is There Still a Gender Gap?

Anti-Cancer Vaccine for HPV-Associated Neoplasms: Focus on a Therapeutic HPV Vaccine Based on a Novel Tumor Antigen Delivery Method Using Endogenously Engineered Exosomes

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