Susceptibility of 302 Methicillin-Resistant Staphylococcus aureus Isolates from 20 European University Hospitals to Vancomycin and Alternative Antistaphylococcal Compounds

Fj, Schmitz; A, Krey; Geisel, Roland; Verhoef, J.; Hp, Heinz; Ac, Fluit

doi:10.1007/s100960050340

Cited by 23 publications

(12 citation statements)

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“…Furthermore, a majority of the MRSA isolates were resistant to multiple other antimicrobial agents, as previously noted in the literature (8,21,22). In general, elevated rates of multidrug resistance may emerge from diverse isolates of S. aureus under antimicrobial pressure or as a result of widespread person-to-person transmission of multidrug-resistant isolates (1).…”

Section: Discussionmentioning

confidence: 63%

In Vitro Activities of 28 Antimicrobial Agents against Staphylococcus aureus Isolates from Tertiary-Care Hospitals in Korea: a Nationwide Survey

Kim¹,

Jang²,

Nam

et al. 2004

Antimicrob Agents Chemother

116

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Staphylococcus aureus, one of the most frequently isolated pathogens in both hospitals and the community, has been particularly efficient at developing resistance to antimicrobial agents. As methicillin-resistant S. aureus (MRSA) has prevailed and, furthermore, as S. aureus with reduced susceptibility to vancomycin has emerged, the therapeutic options for the treatment of S. aureus infections have become limited. To update the current status of antibiotic resistance, clinical S. aureus isolates were collected from eight university-affiliated hospitals from June 1999 to January 2001. Susceptibility tests with 28 antibiotics were performed by the disk diffusion method. Among a total of 682 isolates, the methicillin resistance rate was 64% (439 of 682), and most of the MRSA isolates were resistant to multiple classes of antibiotics. Although a constitutive macrolidelincosamide-streptogramin B resistance phenotype was common, no isolates were resistant to quinupristindalfopristin or linezolid. Rifampin, fusidic acid, trimethoprim-sulfamethoxazole, and arbekacin showed superior in vitro activity compared with the other antibiotics against the MRSA isolates. No isolates showed reduced susceptibility to vancomycin.Staphylococcus aureus is an important cause of serious infections in both hospitals and the community (16). S. aureus has been found to be the most frequently isolated pathogen causing bloodstream infections, skin and soft tissue infections, and pneumonia (6,19,20). Unfortunately this pathogen has been particularly efficient at developing resistance to antimicrobial agents. Since the first isolation of methicillin-resistant S. aureus (MRSA) in the United Kingdom in 1961 (12), increasing rates of methicillin resistance among S. aureus strains have been a cause for concern. In addition, MRSA has become resistant to multiple other antimicrobial agents. Until recently, vancomycin was believed to have retained activity against all strains of S. aureus; therefore, the spread of MRSA has led to increased vancomycin usage and hence increased selective pressure for the development of resistance.In 1997, the first documented infection caused by S. aureus with reduced susceptibility to vancomycin (vancomycin-intermediate S. aureus) was reported in Japan (9). Subsequently, similar strains with reduced susceptibility to vancomycin were identified in several countries, including Korea (25). The aims of the present study were to analyze nationwide data on the susceptibilities of S. aureus isolates from tertiarycare hospitals and to improve the empirical approaches to the therapy of serious infections.(This work was presented in part at the 41st Annual Interscience Conference on Antimicrobial Agents and Chemotherapy, Chicago, Ill., 16 to 19 December 2001.) MATERIALS AND METHODSBacterial isolates. Clinical S. aureus isolates were collected from eight university-affiliated hospitals, each hospital representing one of eight provinces in Korea. From June 1999 to January 2001, each participating hospital sent 100 consecutive isol...

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Section: Discussionmentioning

confidence: 63%

In Vitro Activities of 28 Antimicrobial Agents against Staphylococcus aureus Isolates from Tertiary-Care Hospitals in Korea: a Nationwide Survey

Kim¹,

Jang²,

Nam

et al. 2004

Antimicrob Agents Chemother

116

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“…These isolates represent S. aureus strains from around the world, including Japan (19), Korea (24), Hong Kong (40), Thailand (37), France (3,30), Spain (1), Greece (23), Germany (2,14), Italy (26), and the United Kingdom (21,31). Interestingly, some of these strains have been present in several countries since the early 1990s but were not identified by routine laboratory testing (1, 2).…”

Section: Epidemiology Of Hvisamentioning

confidence: 99%

Staphylococcus aureus with Heterogeneous Resistance to Vancomycin: Epidemiology, Clinical Significance, and Critical Assessment of Diagnostic Methods

Liu

Chambers

2003

Antimicrob Agents Chemother

296

236

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“…Recently, we investigated the seven strains for which the vancomycin MIC was 4 g/ml for their hetero-glycopeptide-intermediate resistance status. However, neither GISA nor hetero-GISA was detected (15). Nevertheless, it is important to carefully monitor the prevalence of (hetero-)GISA, especially in MRSA populations because of the almost invariable multidrug-resistant nature of MRSA.…”

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confidence: 98%

Epidemiology and Susceptibility of 3,051 Staphylococcus aureus Isolates from 25 University Hospitals Participating in the European SENTRY Study

et al. 2001

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A total of 3,051 methicillin-susceptible Staphylococcus aureus (MSSA) isolates and methicillin-resistant S. aureus (MRSA) isolates in Europe were compared. MRSA isolates constituted 25% of all isolates and were more prevalent in southern Europe. MRSA isolates appeared to be more prevalent in intensive care units than in outpatient departments. Only a small minority of MSSA isolates were multidrug resistant, whereas the majority of MRSA isolates were multidrug resistant.

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Susceptibility of 302 Methicillin-Resistant Staphylococcus aureus Isolates from 20 European University Hospitals to Vancomycin and Alternative Antistaphylococcal Compounds

Cited by 23 publications

References 0 publications

In Vitro Activities of 28 Antimicrobial Agents against Staphylococcus aureus Isolates from Tertiary-Care Hospitals in Korea: a Nationwide Survey

In Vitro Activities of 28 Antimicrobial Agents against Staphylococcus aureus Isolates from Tertiary-Care Hospitals in Korea: a Nationwide Survey

Staphylococcus aureus with Heterogeneous Resistance to Vancomycin: Epidemiology, Clinical Significance, and Critical Assessment of Diagnostic Methods

Epidemiology and Susceptibility of 3,051 Staphylococcus aureus Isolates from 25 University Hospitals Participating in the European SENTRY Study

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