Susceptibility and progression of end stage renal disease are not associated with angiotensin II type 1 receptor gene polymorphism

Hanna, Mark P.; Shahin, Rasha Mohamad Hosny; Meshaal, Safa; Kostandi, Inas

doi:10.3109/10799893.2014.956757

Cited by 3 publications

(2 citation statements)

References 41 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Of the thirteen studies included, kidney dysfunction was characterized mainly by an estimated glomerular filtration rate (eGFR) equal to or less than 60 ml/min/1.73m 2 [ 18 , 23 , 25 , 27 , 28 ]. The remaining studies used other surrogate measures to determine kidney dysfunction, which included ESRD (undergoing haemodialysis) [ 19 , 21 , 22 , 24 , 26 ], elevated serum creatinine levels [ 20 ] and a combination of serum creatinine levels greater or equal to 170 μmol/l and dipstick proteinuria greater or equal to 2 [ 30 ] or serum creatinine above 1.4 mg/dl (men) and 1.2 mg/dl (women) and urinary albumin to creatinine ratio (ACR) above 30 mg/g [ 29 ]. The CKD patients included in these studies were of different aetiologies, reflective of the diversity in nephropathy present in Africa.…”

Section: Resultsmentioning

confidence: 99%

“…According to the studies included in this review, some SNP’s investigated in the MYH9 [ 28 ], AT1R [ 19 ], and MTHFR [ 20 ] genes failed to predict prevalent CKD, ESRD or related traits (serum creatinine, eGFR and ACR), while variants in the APOL1 [ 27 , 29 , 30 ], apoE [ 21 ], eNOS [ 18 , 20 ], XPD [ 22 ], XRCC1 [ 22 ], renalase [ 23 , 26 ], ADIPOQ [ 31 ] and CCR2 [ 24 ] genes were associated with either prevalent CKD or progression of CKD, ESRD, or other surrogate measures of renal function.…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

An African perspective on the genetic risk of chronic kidney disease: a systematic review

et al. 2018

View full text Add to dashboard Cite

BackgroundIndividuals of African ethnicity are disproportionately burdened with chronic kidney disease (CKD). However, despite the genetic link, genetic association studies of CKD in African populations are lacking.MethodsWe conducted a systematic review to critically evaluate the existing studies on CKD genetic risk inferred by polymorphism(s) amongst African populations in Africa. The study followed the HuGE handbook and PRISMA protocol. We included studies reporting on the association of polymorphism(s) with prevalent CKD, end-stage renaldisease (ESRD) or CKD-associated traits. Given the very few studies investigating the effects of the same single nucleotide polymorphisms (SNPs) on CKD risk, a narrative synthesis of the evidence was conducted.ResultsA total of 30 polymorphisms in 11 genes were investigated for their association with CKD, ESRD or related traits, all using the candidate-gene approach. Of all the included genes, MYH9, AT1R and MTHFR genes failed to predict CKD or related traits, while variants in the APOL1, apoE, eNOS, XPD, XRCC1, renalase, ADIPOQ, and CCR2 genes were associated with CKD or other related traits. Two SNPs (rs73885319, rs60910145) and haplotypes (G-A-G; G1; G2) of the apolipoprotein L1 (APOL1) gene were studied in more than one population group, with similar association with prevalent CKD observed. The remaining polymorphisms were investigated in single studies.ConclusionAccording to this systematic review, there is currently insufficient evidence of the specific polymorphisms that poses African populations at an increased risk of CKD. Large-scale genetic studies are warranted to better understand susceptibility polymorphisms, specific to African populations.Electronic supplementary materialThe online version of this article (10.1186/s12881-018-0702-x) contains supplementary material, which is available to authorized users.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

An African perspective on the genetic risk of chronic kidney disease: a systematic review

et al. 2018

View full text Add to dashboard Cite

show abstract

Systematic review of associations between HLA and renal function

Lowe

Jervis

Payton

et al. 2021

Int J Immunogenetics

View full text Add to dashboard Cite

Introduction: Kidney dysfunction is a highly significant disease, both in the United Kingdom and globally. Many previous studies have reported associations between human leukocyte antigens (HLA) and renal function; this systematic review attempts to identify, summarize and appraise all published studies of these associations.Methods: A literature search was performed using Medline, Embase and Cochrane Central Register of Controlled Trials to identify papers whose keywords included each of the following concepts: HLA, renal failure and genetic association. A total of 245 papers were identified and assessed for eligibility; 35 of these were included in the final study.Results: A total of 95 HLA types and 14 three-locus haplotypes were reported to be associated with either increased or decreased renal function. A number of these findings were replicated by independent studies that reported 16 types were protective against renal dysfunction and 15 types were associated with reduced renal function.A total of 20 HLA types were associated with both increased risk of renal disease and decreased risk by independent studies. Discussion: There is very little consensus on which HLA types have a protective or deleterious effect on renal function. Ethnicity may play a role, with HLA types possibly having different effects among different populations, and it is possible that the different primary diseases that lead to ESRD may have different HLA associations. Some of the studies may contain type I and type II errors caused by insufficient sample sizes, cohort selection and statistical methods. Although we have compiled a comprehensive list of published associations between renal function and HLA, in many cases, it is unclear which associations are reliable. Further studies are required to confirm or refute these findings.

show abstract

Association between angiotensin II receptor type 1 A1166C polymorphism and chronic kidney disease

et al. 2018

View full text Add to dashboard Cite

Studies of the association between angiotensin II receptor type 1 A1166C (AGTR1 A1166C) polymorphism and chronic kidney disease (CKD) risk have yielded conflicting results. We conducted a combined case-control study and meta-analysis to better define this association. The case-control study included 634 end-stage renal disease (ESRD) patients and 739 healthy controls. AGTR1 A1166C genotype was determined using polymerase chain reaction and iPLEX Gold SNP genotyping methods. The meta-analysis included 24 studies found in the PubMed and Cochrane Library databases. Together, the case-control study and meta-analysis included 36 populations (7,918 cases and 6,905 controls). We found no association between the C allele and ESRD (case-control study: OR: 1.02, 95% CI: 0.77–1.37; meta-analysis: OR: 1.07; 95% CI: 0.97–1.18). Co-dominant, dominant, and recessive model results were also not significant. No known environmental factors moderated the effect of AGTR1 A1166C on CKD in our gene-environment interaction analysis. Sensitivity analysis showed an AGTR1 A1166C-CKD association in Indian populations (OR: 1.46, 95% CI: 1.26–1.69), but not in East Asian or Caucasian populations. Additional South Asian studies will be required to confirm the potential role of this polymorphism in CKD.

show abstract

Susceptibility and progression of end stage renal disease are not associated with angiotensin II type 1 receptor gene polymorphism

Abstract: We concluded that the AT1R genotype does not contribute to the genetic susceptibility of ESRD and is not associated with progression of chronic kidney failure to ESRD.

Cited by 3 publications

References 41 publications

An African perspective on the genetic risk of chronic kidney disease: a systematic review

An African perspective on the genetic risk of chronic kidney disease: a systematic review

Systematic review of associations between HLA and renal function

Association between angiotensin II receptor type 1 A1166C polymorphism and chronic kidney disease

Contact Info

Product

Resources

About