Systematic review of associations between HLA and renal function

Lowe, Michael; Jervis, Steven; Payton, Antony; Poulton, Kay; Worthington, Judith; Gemmell, Isla; Verma, Arpana

doi:10.1111/iji.12566

Cited by 7 publications

(6 citation statements)

References 48 publications

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“…An association between HLA-DRB1*11 and ESRD was reported in Taiwanese, Chinese, and Romanian populations [27,36,37]. Only [24,38].…”

Section: Discussionmentioning

confidence: 95%

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Association between Human Leukocyte Antigen and End-Stage Renal Disease in Patients from Transylvania, Romania

Iancu Loga,

Dican,

Chiorean

et al. 2023

IJMS

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End-stage renal disease (ESRD) is the final stage of chronic kidney disease. This study explored the association between human leukocyte antigen (HLA) and ESRD. The interaction between genetic and environmental factors may also play a role in the development of ESRD. The study included 2392 ESRD patients who were awaiting renal transplantation. Blood samples were genotyped by SSOP and SSP-PCR methods. Multivariate logistic regression analysis showed that HLA-A*11 (p = 0.027), HLA-A*34 (p = 0.017), HLA-A*69 (p = 0.012), HLA-B*41 (p < 0.001), HLA-B*50 (p = 0.004), HLA-DRB1*10 (p = 0.027), and HLA-DRB1*14 (p = 0.004) were positively associated with ESRD (OR > 1); HLA-DRB1*07 (p < 0.001), HLA-DRB1*08 (p = 0.005), and HLA-DRB1*13 (p < 0.001) were protective against ESRD (OR < 1); and the three-locus haplotype HLA-A*02–B*41–DRB1*03, containing one susceptible allele, was strongly associated with ESRD (p < 0.001, OR = 3.15). In conclusion, this retrospective analysis of HLA typing in patients with ESRD of various etiologies suggests that molecular data on the HLA polymorphism should be collected in order to identify high-risk ESRD patients and to improve graft survival after kidney transplantation.

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“…An association between HLA-DRB1*11 and ESRD was reported in Taiwanese, Chinese, and Romanian populations [27,36,37]. Only [24,38].…”

Section: Discussionmentioning

confidence: 95%

“…The classification of primary glomerulonephritis is debatable and confusing. A major cause of confusion is the poor correlation between histological and clinical findings, which generates considerable overlaps between diseases defined by clinical features and diseases defined by histological features [24].…”

Section: Discussionmentioning

confidence: 99%

Association between Human Leukocyte Antigen and End-Stage Renal Disease in Patients from Transylvania, Romania

Iancu Loga,

Dican,

Chiorean

et al. 2023

IJMS

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“…Human leukocyte antigen (HLA)-DRB1 is the most important genetic risk factor for RA. Many studies have reported the association of HLA polymorphisms with susceptibility to RA [12][13][14] or CKD [15,16]. Different DRB1 alleles associated with RA are dependent upon various ethnicities: DRB1*04:01 is associated with European RA [12], and DRB1*04:05 is associated with Japanese RA [13].…”

Section: Introductionmentioning

confidence: 99%

Associations of HLA Polymorphisms with Chronic Kidney Disease in Japanese Rheumatoid Arthritis Patients

Higuchi

Oka

Furukawa

et al. 2023

Genes

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Objectives: The prevalence of chronic kidney disease (CKD) was reported to be higher in rheumatoid arthritis (RA) patients than in normal healthy individuals. Human leukocyte antigen (HLA) was associated with RA or CKD. Few studies on the association of HLA with CKD in RA have been reported. Here, we investigated the association of HLA polymorphisms with CKD in Japanese RA patients. Methods: HLA-DRB1 genotyping was conducted in 351 Japanese RA patients with CKD (estimated glomerular filtration rate [eGFR] lower than 60 [mL/min/1.73 m2]) and 959 without CKD (eGFR equal to or higher than 60 [mL/min/1.73 m2]). Associations of allele carrier frequencies of DRB1 with CKD were examined in the RA patients. Results: There was an association of DRB1*13:02 with CKD in RA, but this did not achieve statistical significance (p = 0.0265, odds ratio [OR] 1.70, pc = 0.7412, 95% confidence interval [CI] 1.09–2.64). The DR6 serological group was associated with CKD in RA (p = 0.0008, OR 1.65, 95% CI 1.24–2.20). A gene-dosage effect of DR6 was not detected. Logistic regression analysis showed that the association of DR6 with CKD in RA was independent of clinical characteristics. Conclusions: The present study first revealed the independent predisposing association of DR6 with CKD in Japanese RA patients, although DR6 is known to be protective against RA. Our data suggest direct or indirect roles of HLA for the development of CKD in RA, but the mechanisms are not clear.

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“…Interestingly, these amino acid residues were previously reported to have a significant association with kidney disease. 8…”

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confidence: 99%

“…Interestingly, these amino acid residues were previously reported to have a significant association with kidney disease. 8 Little is known about PLEKHA5, which is highly expressed in kidney, heart, and other organs. Previous studies have revealed the association of this locus with anthropomorphic traits.…”

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confidence: 99%