Survivin as a potential early marker in the carcinogenesis of oral submucous fibrosis

Zhou, Shanghui; Qu, Xingzhou; Yu, Zhiwei; Zhong, Lai‐ping; Ruan, Min; Ma, Chunyue; Wang, Mingyi; Zhang, Chenping; Jian, Xie

doi:10.1016/j.tripleo.2009.10.054

Cited by 27 publications

(27 citation statements)

References 28 publications

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“…PDSCC was also significantly higher in OSCC compared to OSCC‐OSMF. Our study findings are in agreement with Sarode et al , Chaturvedi et al , and Zhou et al , suggesting better grade of tumor differentiation of OSCC arising in OSMF. In OSCC with OSMF, significantly higher WDSCC (89.58%) cases were noted in early stage, whereas, in OSCC group, 50.00% cases of WDSCC and 45.00% cases of MDSCC were reported in early stage.…”

Section: Discussionsupporting

confidence: 93%

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Oral squamous cell carcinoma in the background of oral submucous fibrosis is a distinct clinicopathological entity with better prognosis

Gadbail

Chaudhary

Gawande

et al. 2017

J Oral Pathology Medicine

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Section: Discussionsupporting

confidence: 93%

“…Postoperatively 27.61% of OSCC‐OSMF showed metastasis to cervical lymph node as compared to 41.07% of OSCC. This finding is in agreement with Chaturvedi et al and Zhou et al . It is believed that this difference exists because of the protective effect of OSMF due to presence of fibrosis in the connective tissue stroma.…”

Section: Discussionsupporting

confidence: 93%

Oral squamous cell carcinoma in the background of oral submucous fibrosis is a distinct clinicopathological entity with better prognosis

Gadbail

Chaudhary

Gawande

et al. 2017

J Oral Pathology Medicine

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“…In one of our previous studies it was clearly evident that arecoline dependent IL-6, IL-8 and GRO-α in cell culture leading to DNA double strand breaks through ROS. We demonstrated the similar findings in OSF tissue confirming the above statement and showed the contribution of these inflammatory molecules in malignant transformation [64].…”

Section: Senescence and Epithelial Mesenchymal Interactionssupporting

confidence: 89%

“…Though survivin expression exhibited differences in different stages of the disease, no relationship was found between the degree of survivin expression and the stages of OSF. Furthermore there was no relationship between survivin expression and the stage of OSCC transformed from OSF [64]. These studies confirm the value of survivin as both prognostic and predictive marker in malignant transformation of OSF.…”

Section: Alterations In Cell Cyclesupporting

confidence: 56%

Oral Submucous Fibrosis: Review on Mechanisms of Pathogenesis and Malignant Transformation

Ekanayaka¹,

Tilakaratne²

2013

J Carcinog Mutagen

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Studies focusing on epidemiology, histopathology and molecular biology/pathology on various aspects of oral submucous fibrosis (OSF), especially in the last decade have helped to understand the pathogenesis to a larger extent. In addition research in some aspects of carcinogenesis in the background of fibrosis has also advanced significantly in the recent past allowing us to understand the mechanisms involved in malignant transformation of the most prevalent oral potentially malignant disorder in South Asia. It has been shown that pathogenesis of OSF is directly related to arecoline present in arecanut and most of the alterations in various pathways and molecules leading to accumulation of collagen are mediated as a result of arecoline. Reduction of Matrix metalloproteinases (MMPs) and increased secretion of Tissue inhibitors of matrix metalloproteinases (TIMPs) play the most significant role in collagen accumulation whilst fibrogenic cytokines, mainly TGF-β over expression leads to increased production of collagen. There are various other pathways/molecules contributing to the pathogenesis in varying capacities. Malignant transformation in OSF has also been studied by various groups in the recent past. Role of arecanut as a carcinogen is proven beyond doubt with a large number of animal studies demonstrating its carcinogenicity, mutagenicity and genotoxicity. Studies involved in many molecules implicated in cell cycle regulation, hypoxia, processes leading to DNA double strand breaks, senescence and many other pathways related to carcinogenesis have shown ample evidence for the arecanut induced malignant transformation in OSF. Some of the findings in these studies may be helpful in inventing new treatment strategies for a common disease without an effective treatment up to date. Further, the understanding of mechanisms of malignant transformation may lead to early diagnosis of oral squamous cell carcinoma (OSCC) arising in the background of OSF.

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“…Patients with oral cancer–OSMF are typically young males who present in early stages with better prognostic factors such as: earlier tumor stage (pT) ( p < .001), thinner lesions ( p < .001), lesser incidence of neck metastases ( p < .001), better differentiated tumors ( p < .001), and lesser incidence of ECS ( p < .001). A study from China reported a similar observation of having a higher proportion of well‐differentiated tumors in patients with OSMF …”

Section: Discussionmentioning

confidence: 59%

Oral squamous cell carcinoma arising in background of oral submucous fibrosis: a clinicopathologically distinct disease

et al. 2012

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Survivin as a potential early marker in the carcinogenesis of oral submucous fibrosis

Cited by 27 publications

References 28 publications

Oral squamous cell carcinoma in the background of oral submucous fibrosis is a distinct clinicopathological entity with better prognosis

Oral squamous cell carcinoma in the background of oral submucous fibrosis is a distinct clinicopathological entity with better prognosis

Oral Submucous Fibrosis: Review on Mechanisms of Pathogenesis and Malignant Transformation

Oral squamous cell carcinoma arising in background of oral submucous fibrosis: a clinicopathologically distinct disease

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