Survivin and Caspase-3 Expression in Breast Cancer: Correlation With Prognostic Parameters, Proliferation, Angiogenesis, and Outcome

Nassar, Aziza; Lawson, Diane; Cotsonis, George; Cohen, Cynthia

doi:10.1097/pai.0b013e318032ea73

Cited by 64 publications

(58 citation statements)

References 40 publications

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“…Moreover, it is known to be overexpressed and related with more aggressive behavior, increased tumor recurrence, chemotherapy resistance, increased survival in various tumors [3][4][5][6][10][11][12][13][14][15]. In TC, Haghpanah et al reported the significantly higher survivin expression in TC than in follicular adenoma, and Ito et al reported the significant link between survivin expression and the dedifferentiation of TC [16,17].…”

Section: Discussionmentioning

confidence: 99%

Significance of survivin, caspase-3, and VEGF expression in thyroid carcinoma

Zhang

Meng

et al. 2009

Clin Exp Med

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To investigate the clinical significance of survivin, caspase-3, and vascular endothelial growth factor expression in a subset of thyroid carcinoma and their correlation with prognosis. Sixty-eight cases of thyroid carcinoma (TC), 12 cases of thyroid adenoma (TA) and 10 cases of normal thyroid tissue (NT) were involved in immunohistochemical and real-time RT-PCR analyses for survivin, caspase-3, and VEGF expression. Statistical analyses were performed for differential expression among NT, TA and TC, correlations of their expression with the clinicopathological parameters of TC including histological typing, clinical staging and lymphnode metastasis, and relationship of survivin with caspase-3 or VEGF in TC. We observed higher mRNA expression and positive immunostaining for survivin and VEGF in TC compared with TA and NT, with a significant positive correlation among them and significant correlations with histological typing, clinical staging and lymphnode metastasis in TC, but we could not find any significance of caspase-3 in TC and its significant relationship with survivin expression. Our results indicate that survivin and VEGF are unfavorable molecules for TC evolution and prognosis, and possess positive correlation in TC.

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Section: Discussionmentioning

confidence: 99%

Significance of survivin, caspase-3, and VEGF expression in thyroid carcinoma

Zhang

Meng

et al. 2009

Clin Exp Med

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“…Survivin is a protein that is cell cycle-regulated with a robust increase in the G2/M phase in cancer cells (12,13). Survivin is known to be overexpressed and related with more aggressive behavior, increased tumor recurrence, chemotherapy resistance and increased survival in various tumors (6,(14)(15)(16)(17)(18)(19)(20)(21). As a prognostic factor, survivin expression is significantly associated with a poor clinical outcome in certain types of cancer, including liver (2), colorectal and breast (3,6).…”

Section: Discussionmentioning

confidence: 99%

Significance of survivin expression: Prognostic value and survival in stage III non-small cell lung cancer

Wang

Liu

Yang

et al. 2012

Experimental and Therapeutic Medicine

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Abstract. This study was designed to determine the levels of survivin expression and identify its clinical significance as a prognostic factor for stage III non-small cell lung cancer (NSCLC). A total of 210 cases of stage III NSCLC were collected and the expression levels of survivin and vascular endothelial growth factor A (VEGF-A) in tumor tissues were investigated using immunohistochemistry (IHC).

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“…The activation of effectors caspases, like caspase-3, is an event also known as "point of no return" of apoptosis, beyond which the cells certainly will entry to apoptosis (Asselin et al 2001). The presence of CC3 has been demonstrated in many neoplasms, such as breast cancer, gliomas, neuroblastomas and sarcomas (Konstantinidou et al 2007, Kobayashi et al 2007, Matsubara et al 2008, Nassar et al 2008. Double inactivation of NF1 gene in Schwann cells seems to be the common event in neurofibromas and MPNSTs.…”

Section: Disease Free Survivalmentioning

confidence: 99%

Evaluation of Bcl-2, Bcl-x and Cleaved Caspase-3 in Malignant Peripheral Nerve Sheath Tumors and Neurofibromas

Cunha

Caruso²,

Faria³

et al. 2013

An. Acad. Bras. Ciênc.

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AIMS:To study the expression of Bcl-2, Bcl-x, as well the presence of cleaved caspase-3 in neurofibromas and malignant peripheral nerve sheath tumors. The expression of Bcl-2 and Bcl-x and the presence of cleaved caspase 3 were compared to clinicopathological features of malignant peripheral nerve sheath tumors and their impact on survival rates were also investigated. MATERIALS AND METHODS: The evaluation of Bcl-2, Bcl-x and cleaved caspase-3 was performed by immunohistochemistry using tissue microarrays in 28 malignant peripheral nerve sheath tumors and 38 neurofibromas. Immunoquantification was performed by computerized digital image analysis. CONCLUSIONS: Apoptosis is altered in neurofibromas and mainly in malignant peripheral nerve sheath tumors. High levels of cleaved caspase-3 are more common in tumors with more aggressive histological features and it is associated with lower disease free survival of patients with malignant peripheral nerve sheath tumors.

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Survivin and Caspase-3 Expression in Breast Cancer: Correlation With Prognostic Parameters, Proliferation, Angiogenesis, and Outcome

Abstract: Survivin and caspase-3 expression correlate with poor prognostic parameters (higher histologic grade and high proliferation), but not with outcome, in breast carcinoma patients.

Cited by 64 publications

References 40 publications

Significance of survivin, caspase-3, and VEGF expression in thyroid carcinoma

Significance of survivin, caspase-3, and VEGF expression in thyroid carcinoma

Significance of survivin expression: Prognostic value and survival in stage III non-small cell lung cancer

Evaluation of Bcl-2, Bcl-x and Cleaved Caspase-3 in Malignant Peripheral Nerve Sheath Tumors and Neurofibromas

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