Evaluation of Bcl-2, Bcl-x and Cleaved Caspase-3 in Malignant Peripheral Nerve Sheath Tumors and Neurofibromas

Cunha, Karin Soares Gonçalves; Caruso, Anabela Cunha; Faria, Paulo Antônio Silvestre de; Silva, Licínio Esmeraldo da; Fonseca, Elize Massard da; Geller, Mauro; Lopes, Vânia Silami

doi:10.1590/0001-3765201320120026

Cited by 8 publications

(5 citation statements)

References 37 publications

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“…Suster S et al has also shown that the Bcl2 is positive in synovial sarcomas but it is a non specific marker. [14] A DSRCT was present among the sarcomas in our study which showed desmin, CK and EMA positive with SMA positivity in the stroma. Ordonez NG et al IHC finding of DSRCT with 90% positivity for CK, EMA and desmin with dot like positivity.…”

Section: Discussionsupporting

confidence: 47%

Diagnostic value of immunohistochemistry in soft tissue tumors

Sridevi

Muralitharan

Thanka

2017

APALM

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Background: Diagnosis of soft tissue tumors is a great challenge to pathologist but with the help of immunohistochemistry (IHC), proper analysis and diagnosis of soft tissue tumours can be made easy. The main use of immunohistochemistry in soft tissue neoplasms especially in sarcomas is to identify differentiation in the neoplastic cells.IHC are used as a panel or as single marker depending on the tumor. Methods:A total of 513 soft tissue tumor (STT) cases were collected and reviewed. The cases were separated into as benign, intermediate and malignant cases. In 90 cases of STT in which immunohistochemistry (IHC) were used was further analysed and classified depending on the various positivity and negativity of the marker used .The significance of IHC was also analysed. Result:In our study of 513 cases of STT there were 380 benign cases, 90 malignant cases and 43 intermediate cases. A total of 90 cases of sarcomas were present out of which 54% cases required IHC, 20 % cases required IHC to support the diagnosis but 26% of cases did not require IHC, the diagnosis was made on haematoxylin and eosin (H&E). The IHC markers helped in correct diagnosis of STT cases. Conclusion:Immunohistochemistry plays an important role in grading and giving precise diagnosis of soft tissue tumors. So it is important to use IHC to diagnose STT where haematoxylin and eosin did not give a precise diagnosis. Perfect diagnosis of STT helps in the correct therapeutic management of patients.

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Section: Discussionsupporting

confidence: 47%

Diagnostic value of immunohistochemistry in soft tissue tumors

Sridevi

Muralitharan

Thanka

2017

APALM

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“…Therefore, the expression in a subpopulation of tumor cells in this series, highlights the Schwannian cell population. Bcl-2 is known to be expressed in Schwann cells, although in general it has been reported that malignant PNST tend to show a higher percentage of cells positive and a stronger intensity of staining [43]. As can be seen from the illustration ( Fig.…”

Section: Immunohistochemistrymentioning

confidence: 76%

Sinonasal Tract Neurofibroma: A Clinicopathologic Series of 12 Cases with a Review of the Literature

Azani

Bishop

Thompson

2014

Head and Neck Pathol

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Neurofibroma (NF), a benign peripheral nerve sheath tumor, is very uncommon in the sinonasal tract, with only a few reported cases in the English literature. Cases within the files of the authors' institutions confined to the sinonasal tract were compared to cases reported in the English literature (Medline 1966-2014). The 12 patients included 6 females and 6 males, aged 26-75 years (mean 46.2 years). The patients usually presented clinically with a mass lesion (n = 11), obstruction (n = 4) or pain (n = 3), with an average symptom duration of 42.9 months. Two patients had neurofibromatosis (NF1). Tumors involved the nasal cavity alone (n = 8), maxillary sinus alone (n = 2), or mixed sites (n = 2), with a range of 0.4-4.1 cm (mean 2.2 cm). The tumors were circumscribed, composed of spindled to wavy cells with curvilinear nuclei set in a background of collagenized stroma and mast cells. Nuclear palisading and perivascular hyalinization were not seen. Mitoses were scant. Pleomorphism, necrosis and increased cellularity were absent. By immunohistochemistry, the lesional cells were S100 protein, SOX10 and NFP positive, while CD34 highlighted the perineurium. INI1 was intact, with strong nuclear expression in all cases. All patients had surgical excision without recurrence (mean follow-up 8.6 years). The principle differential diagnoses include schwannoma, perineurioma, fibromatosis, and solitary fibrous tumor. NF of the sinonasal tract occurs in middle-aged patients without a gender predilection, usually with non-specific symptoms present for a long duration. Tumors are relatively large (mean 2.2), and usually affect one site only. Surgery is curative, with only 16.7 % NF1 associated. S100 protein, SOX10 and NFP highlight the Schwann cells, with CD34 highlighting the perineural fibroblasts.

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“…Malignant PNST tend to show higher percentage of cells positivity and stronger intensity of staining [ 33 ].…”

Section: Discussionmentioning

confidence: 99%

“…NF of the sinonasal tract is difficult and often misdiagnosed. Differential diagnoses in the order of frequency are shown as follows [ 18 , 33 ].…”

Section: Discussionmentioning

confidence: 99%

Unusual Case of a Proptosed Eye: Isolated Right Maxillary Neurofibroma

Yap

Fox

Addams-Williams

2016

Case Reports in Pathology

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Neurofibroma is a slow growing benign tumour of the peripheral nerve sheath which is frequently associated with neurofibromatosis type 1 (Prakash et al., 2014). Isolated solitary occurrence of neurofibroma in the maxillary sinus is rare with only 29 reported cases in the literature. We present a rare case of a 70-year-old gentleman who was referred to ENT with a right maxillary sinus neurofibroma with extension into the right inferior orbit. He has significant proptosis, ptosis, and limitation in abduction of the right eye. He has a complicated past history of multiple neurofibromas which were completely excised. Craniofacial MRI shows a large mass filling the right maxillary antrum extending anteriorly into subcutaneous tissue towards nasal ala and posterolaterally into inferior temporal fossa and superiorly into orbit and cavernous sinus involvement. Biopsy of the right maxillary mass revealed cellular spindle cell tumour with wavy collagen bundles within myxoid stroma which is consistent with a neurofibroma. Patient's case was discussed in the skull-base MDT and he has been referred to a specialist center for surgical removal of the neurofibroma with reconstructive surgery. Despite the rarity of this disease, otorhinolaryngologist should consider a possibility of neurofibroma of the paranasal sinuses.

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Evaluation of Bcl-2, Bcl-x and Cleaved Caspase-3 in Malignant Peripheral Nerve Sheath Tumors and Neurofibromas

Cited by 8 publications

References 37 publications

Diagnostic value of immunohistochemistry in soft tissue tumors

Diagnostic value of immunohistochemistry in soft tissue tumors

Sinonasal Tract Neurofibroma: A Clinicopathologic Series of 12 Cases with a Review of the Literature

Unusual Case of a Proptosed Eye: Isolated Right Maxillary Neurofibroma

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