Survivin and autoimmunity; the ins and outs

Ebrahimiyan, Hamidreza; Aslani, Saeed; Rezaei, Nima; Jamshidi, Ahmadreza; Mahmoudi, Mahdi

doi:10.1016/j.imlet.2017.11.004

Cited by 43 publications

(56 citation statements)

References 204 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In malignant scenarios and breakdown of tolerance in autoimmune diseases, apoptosis resistance and mitosis are much more important. Increased expression of survivin in many tumor tissues results in tumor progression, drug resistance, reduced survival time, and poor prognosis for patients …”

Section: Discussionmentioning

confidence: 99%

“…On the other hand, survivin regulates important events in the immune system, such as increased proliferation in differentiated T cells after activation, development and differentiation of effector CD4+ T cells, and maintenance of CD8+ memory T cells. Expression rate of some important molecules in antigen presentation, such as MHC class II and CD80/86 co‐stimulatory molecules are increased because of increased survivin expression . Based on these important functions of survivin, some researchers investigated survivin expression and function in autoimmune diseases, including RA, myasthenia gravis (MG), multiple sclerosis (MS), lichen planus (LP), systemic lupus erythematosus (SLE), systemic sclerosis (SSc), psoriasis (Ps) and inflammatory bowel disease (IBD), but insufficient data are available around survivin expression and regulatory mechanisms of survivin in autoimmune diseases …”

Section: Discussionmentioning

confidence: 99%

“…In RA patients, some researchers reported that survivin was upregulated in serum, PBMCs, synovial fluid and RA synovial fibroblasts cells (RASFs), which correlated with clinical stage, drug resistance, and inflammatory cytokines …”

Section: Discussionmentioning

confidence: 99%

“…In lymphocytes, survivin acts as a protein in development and differentiation of effector CD4+ T cells, proliferation of activated T cells, and maintenance of CD8+ memory T cells. Survivin induces expression of some important proteins like CD80/86, co‐stimulatory molecules, and major histocompatibility complex (MHC) class II molecules . Due to these functions of survivin in the immune system and cellular survival, many researchers studied survivin expression in cancers and autoimmune diseases.…”

Section: Introductionmentioning

confidence: 99%

“…Little has been investigated with respect to the survivin transcripts in RA patients and pertaining to disease pathogenesis. Studies have reported high expression of total survivin in RA synovial fibroblast cells, peripheral blood mononuclear cells (PBMCs), serum, and synovial fluid which correlated with disease activity and joint destruction . Increased serum levels of survivin correlated with expression of Th1 and Th17 pathogenic cytokines in RA patients .…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

microRNA involvement in the regulation of survivin in peripheral blood mononuclear cells from rheumatoid arthritis patients

et al. 2019

Self Cite

View full text Add to dashboard Cite

Aim Impaired regulation of immune tolerance results in autoimmune diseases, such as rheumatoid arthritis (RA). Survivin is an anti‐apoptotic protein and can induce cellular mitosis. In the current study, we assessed the transcript level of total survivin (survivin‐TS) and its three major variants and evaluated the expression level of important micro RNAs (miRNAs) involved in survivin expression regulation in RA patients. Method Peripheral blood mononuclear cells (PBMCs) were isolated from 50 healthy controls and 50 RA‐active patients. RNA extraction was performed and then single‐strand complementary DNA was synthesized. Quantitative real‐time polymerase chain reaction was used to assess the expression level of survivin‐TS and its variants with effective miRNAs in PBMCs. Results Overexpression of survivin‐2B (fold change = 1.57, P = 0.005), survivn‐ΔEx3 (fold change = 1.93, P = 0.009) and downregulation of survivin‐WT (fold change = 0.64, P = 0.0002) were found in PBMCs of patients, while messenger RNA (mRNA) expression of survivin‐TS had no significant difference between RA patients and controls. Expression levels of miR‐335‐5p, miR‐485‐5p, miR‐16‐5p, miR‐150‐5p, miR‐34a‐5p, and miR‐203a‐3p were significantly increased in PBMCs from patients compared with healthy controls. In a correlation study, dysregulation of these miRNAs were not correlated with mRNA expression level of survivin. Conclusion While survivin‐TS was not differently expressed in RA patients, its variants had altered expression. Although miRNAs were aberrantly expressed in PBMCs from RA subjects, they did not regulate survivin‐TS. miRNAs might be involved in RA pathogenesis, but not through controlling survivin.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

microRNA involvement in the regulation of survivin in peripheral blood mononuclear cells from rheumatoid arthritis patients

et al. 2019

Self Cite

View full text Add to dashboard Cite

show abstract

Survivin modulatory role in autoimmune and autoinflammatory diseases

Pahlavan

Kahroba

Samadi

et al. 2019

Journal Cellular Physiology

View full text Add to dashboard Cite

Baculoviral IAP repeat containing 5 (BIRC5) gene encodes the important protein as survivin, a multifunctional protein, which is involved in cellular and molecular networks, progression of cell cycle, homeostasis, developmental morphogenesis, and apoptosis. The proximal BIRC5 promoter possesses specific binding sites for key transcription factors such as nuclear factor κB and signal transducer and activator of transcription 3. Upregulation of survivin exacerbates the autoimmune diseases (AIDs) including multiple sclerosis and myasthenia gravis by reducing the activity threshold of survivin-specific cytotoxic T cells. DNA damage along with upregulation or downregulation of survivin have been demonstrated in initiation and pathogenesis of cancers and AIDs. However, detailed mechanism of survivin function in pathogenesis of AIDs is not well understood. This review focuses on the structure, specificity, regulation, and function of survivin in physiologic conditions and pathogenesis of AIDs.

show abstract

Survivin a pivotal antiapoptotic protein in rheumatoid arthritis

Zafari

Rafiei

Esmaeili

et al. 2019

Journal Cellular Physiology

View full text Add to dashboard Cite

Rheumatoid arthritis (RA) is an autoimmune disease, pathologically characterized by lymphocyte infiltration of the synovial membrane that leads to chronic inflammation and progressive joint damage. RA develops as a result of increased cell infiltration and cell proliferation as well as impaired cell death. Activated cells in joints including lymphocytes and fibroblast-like synoviocytes (FLS) survive for a long time as a consequence of compromised apoptosis, but the mechanism underlying cell survival in synovium remains to be firmly established. Inhibition of apoptosis by survivin, as a critical antiapoptotic protein, contributes to both the persistence of autoreactive T lymphocytes and tumor-like phenotype of FLS in RA. In addition to the antiapoptotic role, survivin also has prognostic relevance in RA prodromal phase. Hence, this review provides an overview of the current knowledge regarding the involvement of survivin protein in the pathogenesis of RA.

show abstract

Survivin and autoimmunity; the ins and outs

Cited by 43 publications

References 204 publications

microRNA involvement in the regulation of survivin in peripheral blood mononuclear cells from rheumatoid arthritis patients

microRNA involvement in the regulation of survivin in peripheral blood mononuclear cells from rheumatoid arthritis patients

Survivin modulatory role in autoimmune and autoinflammatory diseases

Survivin a pivotal antiapoptotic protein in rheumatoid arthritis

Contact Info

Product

Resources

About