Survivin modulatory role in autoimmune and autoinflammatory diseases

Pahlavan, Yasamin; Kahroba, Houman; Samadi, Nasser; Karimi, Abbas; Ansarin, Khalil; Khabbazi, Alireza

doi:10.1002/jcp.28725

Cited by 20 publications

(28 citation statements)

References 116 publications

(177 reference statements)

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“…[ 35 ] Aldo‐ketoreductase family 1, member B8 ( Akr1b8 ), a critical protein in the proliferation and injury repair of the colonic epithelium, [ 36 ] was upregulated in WDPP, RCPP, and RDPP groups compared with the WC and RC groups. Apoptosis inhibitor survivin ( Birc5 [ 37 ] ) was upregulated in RDPP group and proapoptotic regulators ( Bcl2l11 [ 38 ] and Ptpn13 [ 39 ] ) were downregulated in both RCPP and RDPP groups (Figure 3c). Taken together, these altered genes could be associated with the development of cell proliferation.…”

Section: Resultsmentioning

confidence: 99%

Pork Meat Proteins Alter Gut Microbiota and Lipid Metabolism Genes in the Colon of Adaptive Immune‐Deficient Mice

Zhang

Zou

Zhao

et al. 2020

Molecular Nutrition Food Res

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Scope: Excessive consumption of processed meat has been linked to an increasing risk of gut diseases. It is investigated how pork meat proteins affect colon homeostasis between normal and immune-compromised mice. Methods and results: Immune-deficient mice (Rag1 −/− ) and wild-type mice are fed a diet that contains 20% casein or protein isolated from cooked pork or dry-cured pork for 3 months. Rag1 −/− mice show greater variations in transcriptome responses and higher microbial diversity than wild-type mice after consumption of the pork meat protein diets. Intake of pork meat protein diets also increases body weight and induces colonic oxidative stress, low-grade inflammation, and gene expression involved in immune function, cell cycle, and migration. Key genes like Hmox1, Ppara, and Pparg are highly upregulated by pork meat protein. These changes are associated with decreased abundances of Blautia, Bifidobacterium, and Alistipes and increased abundances of Akkermansia muciniphila and Ruminococcaceae. Conclusion: Pork meat proteins affect colon health in both wild-type and Rag1 −/− mice by altering the microbiome profile under the complex interaction with adaptive immunity. The findings herein give a new insight into the understanding of meat intake, immunity, and gut health.

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Section: Resultsmentioning

confidence: 99%

Pork Meat Proteins Alter Gut Microbiota and Lipid Metabolism Genes in the Colon of Adaptive Immune‐Deficient Mice

Zhang

Zou

Zhao

et al. 2020

Molecular Nutrition Food Res

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“…Up-regulation of BIRC5 in autoimmune diseases is reported in recent studies. 4,7,10,21 High BIRC5 level is found in PBMCs of patients with rheumatoid arthritis (RA), 12 myasthenia gravis 21 and multiple sclerosis. 22 We first analyzed BIRC5 gene expression levels in PBMCs by quantitative PCR analysis.…”

Section: Birc5 Gene Is Overexpressed In Pbmcs In Bdmentioning

confidence: 99%

“…9 High BIRC5 gene expression considered in fetal development and pathologic conditions including tumors and autoreactive cell survival. 8,10,11 Recently, survivin dysregulation is taken into consideration strongly in prognosis and disease activity of autoimmune diseases. 10,12 Defective apoptosis is the irrevocable problem in autoimmune diseases.…”

Section: Introductionmentioning

confidence: 99%

“…8,10,11 Recently, survivin dysregulation is taken into consideration strongly in prognosis and disease activity of autoimmune diseases. 10,12 Defective apoptosis is the irrevocable problem in autoimmune diseases. 8 Survivin is an anti-apoptotic protein expressed in fetal development, tumor cells and immune cells.…”

Section: Introductionmentioning

confidence: 99%

“…8 Survivin is an anti-apoptotic protein expressed in fetal development, tumor cells and immune cells. 10,13 Survivin is able to inhibit caspase 3 function in apoptosis process by interfering during G2/M phase of mitosis in deregulated cell cycle checkpoints to promote abnormal cell survival. 14 Studies indicated that posttranslational modifications on survivin like phosphorylation and acetylation have a key role in regulation of cellular functions for survivin.…”

Section: Introductionmentioning

confidence: 99%

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Phosphorylation Modulates Survivin Function in Behcet’s Disease

et al. 2020

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Purpose: Survivin is critical for proliferation, maturation, homeostasis and differentiation of effector and memory lymphocytes. In this study the baculoviral inhibitors of apoptosis proteins (IAPs) repeat containing 5 (BIRC5) mRNA, survivin, and phosphorylated survivin expression were evaluated in peripheral blood mononuclear cells (PBMCs), and plasma of patients with Behcet’s disease (BD). Methods: In this study, 26 Iranian Azari patients diagnosed with BD and 30 healthy controls were recruited. Total RNA was extracted from PBMCs. The expression level of survivin was measured by quantitative real-time polymerase chain reaction (PCR). Survivin plasma levels were measured using survivin Enzyme-linked immunosorbent assays. Also, western blotting analysis was performed to measure phosphorylated-survivin and survivin levels in PBMCs and plasma of patients with BD. Results: In a pilot study, we showed that BIRC5 gene expression increased in BD patients compared with healthy controls (P<0.05). Western blotting analysis indicated that there was an increase in phosphorylated survivin expression in PBMCs of BD patients. Our data from western blot analysis showed survivin level in plasma samples of BD patients was similar to healthy controls. No significant differences were observed between plasma survivin levels in the BD patients compared with control group (P>0.05). The expression of phosphorylated survivin at Thr34 in PBMCs of BD patients with active disease was increased. Plasma phosphorylated survivin levels in having BD patients were also downregulated compared to healthy individuals. Conclusion: Analysis of PBMCs indicated increasing expression level of phosphorylated survivin in PBMCs of BD patients. There was also a downregulation in phosphorylated survivin levels in plasma of BD patients.

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DHX9 contributes to the malignant phenotypes of colorectal cancer via activating NF-κB signaling pathway

Liu

et al. 2021

Cell. Mol. Life Sci.

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Survivin modulatory role in autoimmune and autoinflammatory diseases

Cited by 20 publications

References 116 publications

Pork Meat Proteins Alter Gut Microbiota and Lipid Metabolism Genes in the Colon of Adaptive Immune‐Deficient Mice

Pork Meat Proteins Alter Gut Microbiota and Lipid Metabolism Genes in the Colon of Adaptive Immune‐Deficient Mice

Phosphorylation Modulates Survivin Function in Behcet’s Disease

DHX9 contributes to the malignant phenotypes of colorectal cancer via activating NF-κB signaling pathway

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