Survival trends of cancer amongst the south Asian and non-south Asian population under 30 years of age in Yorkshire, UK

Laar, Marlous van; McKinney, P A; Stark, Dan; Glaser, Adam; Kinsey, Sally; Lewis, Ian; Picton, Susan; Richards, Michael; Norman, Paul; Feltbower, Richard

doi:10.1016/j.canep.2011.08.005

Cited by 7 publications

(15 citation statements)

References 28 publications

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“…The literature reports a mixed role for ethnicity and socioeconomic background in cancer survival ( Parikh-Patel et al , 2006 ; Moles et al , 2007 , Jack et al , 2009 , National Cancer Intelligence Network, 2009 , van Laar et al , 2012 , Ortiz-Ortiz et al , 2014 ). Ethnic differences in 1- and 3-year age-standardised survival for cancers of the colorectum, breast (women) and prostate were reported to be minor, using HES-derived ethnicity ( National Cancer Intelligence Network, 2009 ).…”

Section: Discussionmentioning

confidence: 99%

“…Survival from oral ( Warnakulasuriya et al , 1999 ; Moles et al , 2007 ) and cervical cancers ( Bates et al , 2008 ) was higher among South Asian migrants compared with non-South Asians. By contrast, a regional study of cancer survival in children and young adults under 30 years of age showed that differences between South Asians and non-South Asians vary with the type of tumour: South Asians had poorer survival from leukaemia and lymphoma compared with non-South Asians, but better outcomes from solid tumours ( van Laar et al , 2012 ).…”

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confidence: 97%

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Cancer survival differences between South Asians and non-South Asians of England in 1986–2004, accounting for age at diagnosis and deprivation

Maringe

Mangtani

et al. 2015

Br J Cancer

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Background:South Asian migrants show lower cancer incidence than their host population in England for most major cancers. We seek to study the ethnic differences in survival from cancer.Methods:We described and modelled the effect of ethnicity, time, age and deprivation on survival for the five most incident cancers in each sex in South Asians in England between 1986 and 2004 using national cancer registry data. South Asian ethnicity was flagged using the validated name-recognition algorithm SANGRA (South Asian Names and Group Recognition Algorithm).Results:We observed survival advantage in South Asians in earlier periods. This ethnic gap either remained constant or narrowed over time. By 2004, age-standardised net survival was comparable for all cancers except three in men, where South Asians had higher survival 5 years after diagnosis: colorectal (58.9% vs 53.6%), liver (15.0% vs 9.4%) and lung (15.9% vs 9.3%). Compared with non-South Asians, South Asians experienced a slower increase in breast and prostate cancer survival, both cancers associated with either a screening programme or an early diagnosis test. We did not find differential patterns in survival by deprivation between both ethnicities.Conclusions:Considering recent survival trends, appropriate action is required to avoid deficits in cancer survival among South Asians in the near future.

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 97%

Cancer survival differences between South Asians and non-South Asians of England in 1986–2004, accounting for age at diagnosis and deprivation

Maringe

Mangtani

et al. 2015

Br J Cancer

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“…Ethnicity was defined as South Asian or non-South Asian based on the results from a name recognition software program Onomap [10, 11] and individual patient record linkage to hospital episode statistics data as described in previous studies [8, 12]. The area based Townsend deprivation index [13] was obtained from the patient’s postcode at diagnosis.…”

Section: Methodsmentioning

confidence: 99%

Access to principal treatment centres and survival rates for children and young people with cancer in Yorkshire, UK

et al. 2017

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BackgroundPrincipal Treatment Centres (PTC) were established to provide age-appropriate care as well as clinical expertise for children and young people with cancer. However, little is known about the effects of specialist treatment centres on survival outcomes especially for teenagers and young adults. This population-based study aimed to describe access to PTC and the associated trends in survival for 0–24 year olds accounting for stage of disease at presentation and treatment.MethodsPatients diagnosed from 1998–2009 aged 0–24 years were extracted from the Yorkshire Specialist Register of Cancer in Children and Young People, including information on all treating hospitals, followed-up until 31st December 2014. The six commonest cancer types were included: leukaemia (n = 684), lymphoma (n = 558), CNS tumours (n = 547), germ cell tumours (n = 364), soft tissue sarcomas (n = 171) and bone tumours (n = 163). Treatment was categorised into three groups: ‘all’, ‘some’ or ‘no’ treatment received at a PTC. Treatment at PTC was examined by diagnostic group and patient characteristics. Overall survival was modelled using Cox regression adjusting for case-mix including stage, treatment and other socio-demographic and clinical characteristics.ResultsOverall 72% of patients received all their treatment at PTC whilst 13% had no treatment at PTC. This differed by diagnostic group and age at diagnosis. Leukaemia patients who received no treatment at PTC had an increased risk of death which was partially explained by differences in patient case-mix (adjusted Hazard Ratio (HR) = 1.73 (95%CI 0.98–3.04)). Soft tissue sarcoma patients who had some or no treatment at PTC had better survival outcomes, which remained after adjustment for patient case-mix (adjusted HR = 0.48 (95%CI 0.23–0.99)). There were no significant differences in outcomes for other diagnostic groups (lymphoma, CNS tumours, bone tumours and germ cell tumours). For leukaemia patients survival outcomes for low risk patients receiving no treatment at PTC were similar to high risk patients who received all treatment at PTC, implying a benefit for care at the PTC.ConclusionThis study demonstrates that for leukaemia patients receiving treatment at a PTC is associated with improved survival that may compensate for a poorer prognosis presentation. However, further information on risk factors is needed for all diagnostic groups in order to fully account for differences in patient case-mix.Electronic supplementary materialThe online version of this article (doi:10.1186/s12885-017-3160-5) contains supplementary material, which is available to authorized users.

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“…As no previous literature exists on hospital admissions occurring during end of life care for childhood cancer, the variables included within the analysis as mentioned previously were chosen based on standard variables used within the literature of survival of childhood cancer (Wilkinson et al , 2001; Magnani et al , 2006; Basta et al , 2011; van Laar et al , 2012). The impact of referral on SPPCS was explored using negative binomial regression modelling (which was chosen over Poisson regression due to overdispersion), with the total number of hospital admissions as the main outcome.…”

Section: Methodsmentioning

confidence: 99%

Does referral to specialist paediatric palliative care services reduce hospital admissions in oncology patients at the end of life?

et al. 2013

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Background:Despite advances in the treatment of childhood cancer, some children continue to die from their disease. This study aimed to assess the impact of specialist paediatric palliative care services (SPPCSs) on the number of hospital admissions in children who subsequently died from cancer in Yorkshire, UK.Methods:An extract of patients aged 0–19 years from the Yorkshire Specialist Register of Cancer in Children and Young People (YSRCCYP) diagnosed from 1990 to 2009 were linked to inpatient hospital episodes data and a SPPCS database. Deaths were included if they occurred before 31 August 2011. Differences in hospital admission patterns were assessed using negative binomial regression and presented as incidence rate ratios (IRRs).Results:Of 2508 children on the YSRCCYP, 657 (26%) had died by the censoring date. A total of 211 children had been referred to the local SPPCS, of whom 182 (86%) had subsequently died. Referral to SPPCS was associated with a significant reduction in the rate of planned hospital admissions (IRR=0.60, 95% CI 0.43–0.85). Central nervous system tumours showed significant decreases for all planned and emergency admissions compared with all other diagnostic groups.Conclusion:Referral to SPPCS significantly reduced the number of planned hospital admissions for children and young people with cancer before their death, which are often integral to paediatric oncology treatment regimens. Overall, our findings show that SPPCS have a role in reducing hospital admissions during end of life care of paediatric cancer patients with potential personal, social and economic benefits.

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Survival trends of cancer amongst the south Asian and non-south Asian population under 30 years of age in Yorkshire, UK

Cited by 7 publications

References 28 publications

Cancer survival differences between South Asians and non-South Asians of England in 1986–2004, accounting for age at diagnosis and deprivation

Cancer survival differences between South Asians and non-South Asians of England in 1986–2004, accounting for age at diagnosis and deprivation

Access to principal treatment centres and survival rates for children and young people with cancer in Yorkshire, UK

Does referral to specialist paediatric palliative care services reduce hospital admissions in oncology patients at the end of life?

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