Survival Outcomes in Surgical Treatment of 72 Cases of Squamous Cell Carcinoma of the Temporal Bone

Abstract

An en bloc resection is favored in an effort to produce negative surgical margins for squamous cell carcinoma of the temporal bone. Adjunctive radiotherapy is used for advanced lesions.

Predictors of Survival and Recurrence after Temporal Bone Resection for Cancer

“…The literature on temporal bone resection includes important data that have been contributed by several large series. 2,6,16,20,21,23,24 However, most of these reports have been based on patients treated over the past half-century or longer. Treatment has changed substantially during this time.…”

“…Several larger series have reported preliminary descriptions of factors influencing survival, based on univariate comparisons. 2,6,7,16,20,21,24 In this study, we use multivariable analyses to identify factors independently associated with survival and recurrence in 72 patients undergoing temporal bone resection over 16 years at our 2 affiliated institutions. In all, 80% of cases were epithelial cancers, and 83% of patients underwent lateral temporal bone resection as the primary temporal bone procedure.…”

“…The extant literature consists of numerous case series that have reported a wide range of survival data, reflecting differences in the underlying characteristics of cohorts drawn from various institutions. 1,6,[8][9][10][12][13][14][15]18,19,22,24,[30][31][32][33][34][35][36][37][38][39][40][41] Historical survival data can be most readily generalized to clinical practice if factors predictive of outcome can be identified. Several larger series have reported preliminary descriptions of factors influencing survival, based on univariate comparisons.…”

“…Most cohorts have been limited to squamous cell histology, and comprehensive outcomes analyses have been limited. 2,[6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23][24] Further complicating analysis, there is no recognized American Joint Committee on Cancer (AJCC) or Union Internationale Contre le Cancer (UICC) staging system for tumors of the external auditory canal/temporal bone, with multiple systems having been proposed. 3,16,25,26 To date, the most widely used system is the University of Pittsburgh staging system, first described in 1990 by Arriaga and colleagues 25 and modified in 2000 by Moody et al 3 Other than Pittsburgh stage and surgical margin status, no other factors have been consistently demonstrated to be associated with outcome, and multivariable analyses of factors affecting outcome have not been reported.…”

Predictors of survival and recurrence after temporal bone resection for cancer

“…Most cohorts have been limited to squamous cell histology, and comprehensive outcomes analyses have been limited. 2,6–24 Further complicating analysis, there is no recognized American Joint Committee on Cancer (AJCC) or Union Internationale Contre le Cancer (UICC) staging system for tumors of the external auditory canal/temporal bone, with multiple systems having been proposed. 3,16,25,26 To date, the most widely used system is the University of Pittsburgh staging system, first described in 1990 by Arriaga and colleagues 25 and modified in 2000 by Moody et al 3 …”