Survival outcomes after endoscopic resection for sinonasal squamous cell carcinoma arising on inverted papilloma

Karligkiotis, Apostolos; Lepera, Davide; Volpi, Luca; Turri‐Zanoni, Mario; Battaglia, Paolo; Lombardi, Davide; Accorona, Remo; Bignami, Maurizio; Nicolai, Piero; Castelnuovo, Paolo

doi:10.1002/hed.24481

Cited by 36 publications

(43 citation statements)

References 61 publications

(101 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Often, transformed IPs are difficult to detect preoperatively with in‐office biopsies, particularly if the tumors are not easily visible by nasal endoscopy, or if they have large tumor mass thereby increasing sampling error. Some authors have recommended performing multiple biopsies because most malignancies expand from the center of the IP . However, a significant number of IP tumors are found in the maxillary sinus, which is a difficult site to biopsy in patients who have had no prior sinus surgery, and even in operated patients, obtaining biopsies from the anterior or lateral reaches of the sinus can be difficult in an awake patient.…”

Section: Discussionmentioning

confidence: 99%

“…Some authors have recommended performing multiple biopsies because most malignancies expand from the center of the IP. 17 However, a significant number of IP tumors are found in the maxillary sinus, which is a difficult site to biopsy in patients who have had no prior sinus surgery, and even in operated patients, obtaining biopsies from the anterior or lateral reaches of the sinus can be difficult in an awake patient.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Imaging predictors for malignant transformation of inverted papilloma

et al. 2018

View full text Add to dashboard Cite

Objectives/Hypothesis Inverted papillomas (IPs) are benign tumors of the sinonasal tract with a malignant transformation potential. Predicting the transformation propensity of IPs and corresponding risk factors has long been a challenge. In this study, we aimed to use radiographic findings on magnetic resonance imaging (MRI) and computed tomography (CT) to help differentiate IP from IP‐transformed squamous cell carcinomas (IP‐SCC). Study Design Retrospective cohort study. Methods A retrospective analysis was performed at two institutions comparing IP (n = 76) and IP‐SCC (n = 66) tumors, evaluating preoperative radiographic imaging with corresponding surgical pathology reports. The presence of a convoluted cerebriform pattern (CCP) using postcontrast T1‐weighted and T2‐weighted MRI was evaluated. Using MRI diffusion‐weighted imaging (DWI), we calculated the apparent diffusion coefficient (ADC) value of each tumor. We also determined the tumor origin, attachment sites, and presence of bony erosion using CT imaging. Results Benign IPs had a higher prevalence of CCP on MRI compared to IP‐transformed SCC (P = .0001. The mean value ADC of malignant IP‐SCC (ADCb0,1000 = 1.12 × 10−3 mm2/s) was significantly lower than that of benign IPs (ADCb0,1000 = 1.49 × 10−3 mm2/s, P = .002). IP‐SCC tumors were more likely to be have orbital wall attachment (P = .002) and bony erosion (P < .0001) compared to IPs. Conclusions Evaluation of CCP and DWI with ADC values on MRI are promising qualitative and quantitative methods to help differentiate benign IP tumors from their transformed malignant counterparts. Malignant IP‐SCCs are associated with a loss of CCP and lower ADC values. Findings of orbital wall involvement and bony erosion on CT may also help determine presence of malignancy. Level of Evidence 4 Laryngoscope, 129:777–782, 2019

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Imaging predictors for malignant transformation of inverted papilloma

et al. 2018

View full text Add to dashboard Cite

show abstract

“…Currently, there is no evidence to suggest that these tumors should be treated as de novo SCC. Furthermore, owing to the small number of patients studied, the prognostic factors and survival outcomes reported by a few retrospective studies are inconsistent . In this study, 120 treated patients with SCC originating from IPs were retrospectively analyzed with emphasis on the clinical behavior, risk factors, and oncologic outcomes.…”

mentioning

confidence: 99%

Survival outcomes and prognostic factors of squamous cell carcinomas arising from sinonasal inverted papillomas: a retrospective analysis of 120 patients

Wang

et al. 2019

Int Forum Allergy Rhinol

View full text Add to dashboard Cite

Background:This study aimed to analyze the prognostic factors and survival outcomes of squamous cell carcinoma (SCC) originating from sinonasal inverted papillomas (IPs), based on data from a single institution. Methods:The data from 120 patients treated at the affiliated Beijing Tongren Hospital, Capital Medical University, for SCC originating from sinonasal IPs between 2005 and 2018 were retrospectively reviewed. Data related to demographic features, tumor characteristics, treatment modality, and clinical outcomes were collected. Survival data were investigated using the Kaplan-Meier method, Cox regression analysis, and the nomogram model predictive of survival probabilities.Results: Among 1034 patients with sinonasal IPs, 120 patients (11.6%) with malignancy were identified. The overall survival (OS) and disease-free survival (DFS) rates at 5 years were 56.0% and 42.3%, respectively. Multivariate analysis showed that synchronous tumors and tumor stage were independent predictive factors for the risk of mortality (hazard ratio [HR], 1.954; 95% confidence interval [CI], 1.022-3.737, p = 0.043; HR, 1.737, 95% CI, 1.095-2.770, p = 0.020, respectively). The surgical margin was another important independent predictor, with patients with negative margins demonstrating a more than 2-fold improved survival compared to those with positive margins (HR, 2.095; 95% CI, 1.031-4.243; p = 0.041). Conclusion:The main factors affecting the prognosis and outcomes were synchronous tumors, advanced tumor stage, and positive surgical margins. These findings highlight the importance of tumor biology and early detection in patient outcomes. In addition, risk factors should be taken into consideration during treatment planning and subsequent tumor surveillance. C 2019 ARS-AAOA, LLC.

show abstract

“…The majority of the studies were retrospective analyses. A number of studies focused on surgical methods and were published in prominent otorhinolaryngology journals in 2015 and 2016 (61)(62)(63)(64). Notably, there were a limited number of experimental studies.…”

Section: Potential Mechanisms Underlying the Recurrence And Malignantmentioning

confidence: 99%

Advances in recurrence and malignant transformation of sinonasal inverted papillomas

Sun

Zheng

et al. 2017

Oncology Letters

View full text Add to dashboard Cite

Abstract. Sinonasal inverted papilloma (SIP) is a benign tumor of the nasal cavity and sinus. SIP is characterized by aggressive malignant transformation and a high rate of recurrence. Inadequate removal of the tumor during surgery is one of the most significant contributors to SIP recurrence. A growing body of evidence suggests that molecular alteration in SIP, including human papilloma virus infections, single nucleotide polymorphisms of key genes, deregulation of signaling pathways and immunological changes, may lead to SIP occurrence and malignant transformation. However, the extent to which these molecular mechanisms contribute to SIP pathology and transformation remains unclear due to limited research. Further studies are warranted to elucidate the primary dependent factors that contribute to SIP etiology. The present article reviewed risk factors of progression and recurrence of SIP, including outdoor and industrial occupational exposure, smoking, septal deviation, SIP location, recurrent cases, stage of SIP-associated squamous cell carcinoma and choice of surgical method.

show abstract

Survival outcomes after endoscopic resection for sinonasal squamous cell carcinoma arising on inverted papilloma

Abstract: The endoscopic approach provides encouraging oncologic outcomes for sinonasal IP-SCC, comparable to those observed with traditional external approaches while minimizing morbidity for patients. © 2016 Wiley Periodicals, Inc. Head Neck 38: 1708-1716, 2016.

Cited by 36 publications

References 61 publications

Imaging predictors for malignant transformation of inverted papilloma

Imaging predictors for malignant transformation of inverted papilloma

Survival outcomes and prognostic factors of squamous cell carcinomas arising from sinonasal inverted papillomas: a retrospective analysis of 120 patients

Advances in recurrence and malignant transformation of sinonasal inverted papillomas

Contact Info

Product

Resources

About