Survival outcomes and prognostic factors of squamous cell carcinomas arising from sinonasal inverted papillomas: a retrospective analysis of 120 patients

Li, Yunxia; Wang, Ru; He, Shizhi; Li, Feng; Lian, Meng; Shi, Qian; Chen, Xiaohong; Fang, Jugao; Zhang, Luo

doi:10.1002/alr.22400

Cited by 13 publications

(17 citation statements)

References 27 publications

(33 reference statements)

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“…Detection of tumors at an early stage is thus of utmost importance, and may have a significant prognostic advantage. Regarding surgical margins, our findings for this aspect are also in accordance with the findings from several studies, 14,27,28 which have shown positive margins to be associated with poor survival outcomes. However, the positive margin rate noted in our study was higher compared with other studies.…”

Section: Discussionsupporting

confidence: 92%

Prognostic Factors of Sinonasal Squamous Cell Carcinomas Arising De Novo and From Inverted Papilloma

Wang

Zhang

et al. 2020

Am J Rhinol�Allergy

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Background The prognostic factors and survival difference between inverted papilloma (IP)-associated sinonasal squamous cell carcinoma (SCC) and de novo SCC are unclear. Objective This study aimed to compare the clinical features and oncologic outcomes in patients with IP-associated SCC and de novo SCC; and additionally, to analyze the prognostic factors of the two types of SCCs. Methods Data from 173 SCC patients treated for IP-associated SCC (n = 89) and de novo SCC (n = 84), were reviewed retrospectively for demographic features, tumor characteristics, treatment modality, and clinical outcomes. 5-year overall survival (OS) and disease free survival (DFS) was analyzed using the Kaplan-Meier method, and Cox proportional hazards model was used to analyze factors influencing prognosis. Results A higher proportion of IP-associated SCC occurred in frontal and sphenoid sinus compared to de novo SCC. The two groups demonstrated similar 5-year OS and DFS (5-year OS: 63.3% and 55.4%, DFS: 45.4% and 50.1%, respectively). The metachronous tumor had a relatively better prognosis outcome than synchronous tumor and de novo SCC (5-year OS: 73.1%, 54.5% and 55.4%, respectively). Both groups showed similar loco-regional recurrence rates ( p > 0.05); however, de novo SCC tumors demonstrated an increased incidence of distant metastasis. Multivariate analysis indicated that age >70 years, advanced tumor stage and surgical margin were independent predictive factors for the risk of mortality (HR 2.047, 1.581 and 1.931, respectively). Conclusion IP-associated SCCs have an aggressive loco-regional tendency, whereas de novo SCCs have a higher aggressive distant metastatic propensity. Age, tumor stage and surgical positive margin are key factors for poor prognosis and should be routinely taken into consideration during treatment planning and subsequent surveillance.

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Section: Discussionsupporting

confidence: 92%

Prognostic Factors of Sinonasal Squamous Cell Carcinomas Arising De Novo and From Inverted Papilloma

Wang

Zhang

et al. 2020

Am J Rhinol�Allergy

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“…[18][19][20] Besides the risk of recurrence, there is also the risk of malignant transformation, which is seen in 5% to 11% of all specimens. 14,[21][22][23][24][25][26] Previous series reported a rate of approximately 2:1 of synchronous to metachronous transformation. 22 Treatment of SNIPs primarily consists of David Holzmann and Christian M. Meerwein contributed equally to this study and worked as joint last authors.…”

Section: Introductionmentioning

confidence: 99%

“…Besides the risk of recurrence, there is also the risk of malignant transformation, which is seen in 5% to 11% of all specimens 14,21‐26 . Previous series reported a rate of approximately 2:1 of synchronous to metachronous transformation 22 .…”

Section: Introductionmentioning

confidence: 99%

Need for long‐term follow‐up in sinonasal inverted papilloma: A Single‐institution experience

et al. 2020

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Background: Most studies on sinonasal inverted papillomas (SNIPs) regarding risk factors for recurrence, recurrence rates (RRs) and malignant transformation are biased by a significant proportion of revision cases. Methods: Retrospective study on patients with consecutive, treatment-naïve SNIPs at a tertiary referral center between 1999 and 2019. Results: Overall, RR was 9.8% (10 of 102 patients), with 2 of 10 recurrences (20%) occurring after more than 5 years. Histopathological workup revealed synchronous malignancy in 2 of 102 patients (2%). Subgroup analysis revealed a significantly higher RR for SNIPs involving the frontal sinus (26.3% vs 6.0%, P = .02). No SNIPs primarily originating from the frontal sinus were observed. Conclusion: Overall, RR of treatment-naïve SNIPs is comparably low; however, long-term follow-up is mandatory due to late recurrences. Secondary involvement of the frontal sinus was identified as risk factor for recurrence. No SNIPs primarily originating from frontal sinus were observed.

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“…The incidence of IP associated with the synchronously or metachronous SCC is reported from 2% to 53% ( 2 – 5 ), in which synchronous SCC accounts for approximately 55%–70% ( 2 , 5 , 6 ). Therefore, it is essential for precision diagnosis and treatment as well as prognosis to accurately predict IP-SCC preoperatively ( 3 , 7 , 8 ). However, it is very difficult to diagnose IP-SCC preoperatively due to similarity in clinical presentation and imaging findings with IP ( 9 ).…”

Section: Introductionmentioning

confidence: 99%

Preoperative Prediction of Malignant Transformation of Sinonasal Inverted Papilloma Using MR Radiomics

et al. 2022

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PurposeAccurate preoperative prediction of the malignant transformation of sinonasal inverted papilloma (IP) is essential for guiding biopsy, planning appropriate surgery and prognosis of patients. We aimed to investigate the value of MRI-based radiomics in discriminating IP from IP-transformed squamous cell carcinomas (IP-SCC).MethodsA total of 236 patients with IP-SCC (n=92) or IP (n=144) were enrolled and divided into a training cohort and a testing cohort. Preoperative MR images including T1-weighted, T2-weighted, and contrast enhanced T1-weighted images were collected. Radiomic features were extracted from MR images and key features were merged into a radiomic model. A morphological features model was developed based on MR morphological features assessed by radiologists. A combined model combining radiomic features and morphological features was generated using multivariable logistic regression. For comparison, two head and neck radiologists were independently invited to distinguish IP-SCC from IP. The area under the receiver operating characteristics curve (AUC) was used to assess the performance of all models.ResultsA total of 3948 radiomic features were extracted from three MR sequences. After feature selection, we saved 15 key features for modeling. The AUC, sensitivity, specificity, and accuracy on the testing cohort of the combined model based on radiomic and morphological features were respectively 0.962, 0.828, 0.94, and 0.899. The diagnostic ability of the combined model outperformed the morphological features model and also outperformed the two head and neck radiologists.ConclusionsA combined model based on MR radiomic and morphological features could serve as a potential tool to accurately predict IP-SCC, which might improve patient counseling and make more precise treatment planning.

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Survival outcomes and prognostic factors of squamous cell carcinomas arising from sinonasal inverted papillomas: a retrospective analysis of 120 patients

Cited by 13 publications

References 27 publications

Prognostic Factors of Sinonasal Squamous Cell Carcinomas Arising De Novo and From Inverted Papilloma

Prognostic Factors of Sinonasal Squamous Cell Carcinomas Arising De Novo and From Inverted Papilloma

Need for long‐term follow‐up in sinonasal inverted papilloma: A Single‐institution experience

Preoperative Prediction of Malignant Transformation of Sinonasal Inverted Papilloma Using MR Radiomics

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