Survival of patients with invasive cervical cancer in French Guiana, 2003-2008

Douine, Maylis; Roué, Tristan; Fior, Andrea; Adenis, Antoine; Thomas, Nadia

doi:10.1016/j.ijgo.2013.10.031

Cited by 13 publications

(15 citation statements)

References 5 publications

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“…However, the same result was found in metropolitan France where the cultural and social context is very different (3,6). The median age at the time of diagnosis of cervical cancer in French Guiana being 49 years old, it is important to maintain a high screening rate after 45 (5). An evaluation by the French National Surveillance Institute (InVS) showed that organized screening improves the screening coverage particularly after 50 years of age in pilot departments in France (7).…”

Section: Discussionmentioning

confidence: 99%

“…But those rates were calculated with screening pap smears, while in French Guiana it was with all pap smears, including smears realised because of symptoms. And in that territory, 73% of women with cervical cancer have been diagnosed because of symptoms (5), which could partially explain the higher rate of invasive cervical cancer rate in French Guiana.…”

Section: Discussionmentioning

confidence: 99%

“…A survival study in this population revealed that stage at diagnosis was the main factor influencing the prognosis, showing that early detection is crucial to increase cervical cancer survival (5). The gold standard for screening is the Papanicolaou cervical smear (pap smear).…”

Section: Introductionmentioning

confidence: 98%

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Screening for cervical cancer in French Guiana: screening rates from 2006 to 2011

Douine

Roué²,

Lelarge³

et al. 2015

Bull. Soc. Pathol. Exot.

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In French Guiana, the age-standardized incidence rate of cervical cancer is four times higher than in France and the mortality rate 5.5 times higher. A survival study revealed that stage at diagnosis was the main factor influencing the prognosis, showing that early detection is crucial to increase cervical cancer survival. The present study aimed at evaluating the cervical cancer screening rate between 2006 and 2011 by age and for a 3-year period in French Guiana. All pap smears realised in French Guiana were analysed in two laboratories allowing exhaustive review of screening data. The screening rate was estimated at about 54% from 2006 to 2011, with a statistical difference between coastal and rural area (56.3% versus 18.7%). Although the methodological difference did not allow comparisons with metropolitan France, these results could be used to evaluate the impact of organised cervical cancer screening by the French Guiana Association for Organized Screening of Cancers which has been implemented in French Guiana since 2012.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Screening for cervical cancer in French Guiana: screening rates from 2006 to 2011

Douine

Roué²,

Lelarge³

et al. 2015

Bull. Soc. Pathol. Exot.

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“…Cervical cancer follows Human Papilloma Virus (HPV) infection. In French Guiana, the standardized incidence rate of cervical cancer is 30.3 per 100,000 women, thus representingthe second most frequent cancer in females [ 1 ] and a significant cause of mortality [ 2 ]. These figures show that the epidemiology of cervical cancer in French Guiana, a French territory, is closer to what is observed in developing countries than in France [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

Predictors of abnormal cytology among HPV-infected women in remote territories of French Guiana

et al. 2018

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BackgroundCervical cancer prevention using cervical cytology is insufficiently sensitive, a significant proportion of HPV-infected women having normal cytology.The objective of the present study was to try to identify factors associated with abnormal cytology in HPV-infected women living in remote areas of French Guiana.MethodsA study was conducted in women aged 20–65 years having HPV infections confirmed by HPV DNA detection using the GREINER-BIO-ONE kit. In addition to HPV testing, cytology was performed and classified as normal or abnormal. Demographic and life history variables, and infecting genotypes were compared between the normal and abnormal cytology groups.ResultsNone of the demographic and life history variables were associated with cytology results. HPV genotype 53 was significantly associated with absence of cytological abnormalities whereas HPV 52, 58, 16 and perhaps 33 and 66 were independently associated with a greater risk of cytological abnormalities. When grouping HPV genotypes in different species, only species 9 (HPV 16, 31, 33, 35, 52, 58, 67) was significantly associated with abnormal cytology AOR = 5.1 (95% CI = 2.3–11.2), P < 0.001.ConclusionsIt was not possible to predict which HPV-infected women will have cytological abnormalities or notfrom anamnesis. In this study HPV 53 seemed more benign than other HPV genotypes. On the contrary, species n°9, containing 5 of the genotypes contained in the nonavalent HPV vaccine, was significantly associated with more cytological abnormalities. HPV testing and vaccination with the nonavalent vaccine should be implemented in these remote parts of French Guiana.

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“…In French Guiana, the standardized incidence rate of cervical cancer is 30.3 per 100,000 women. It is the second most frequent cancer in females [1] and causes significant mortality [2]. These figures show that the epidemiology of cervical cancer in French Guiana, a French territory, is South American rather than French [3].…”

Section: Introductionmentioning

confidence: 99%

The singular epidemiology of HPV infection among French Guianese women with normal cytology

et al. 2017

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BackgroundIn French Guiana, cervical cancer is the second most frequent cancer in females. The objective of the present study was to describe the prevalence of HPV infections in women with normal cervical cytology living in the remote villages of French Guiana.MethodsBefore the study, the study team communicated in the remote villages on the importance of screening. All women from the target population were offered to participate. They signed informed consent during inclusion and then had a concomitant HPV-test and cervical smear. Only women with normal cytology and a good quality smear were analyzed. The detection of HPV-DNA was performed using the GREINER-BIO-ONE kit.ResultsOverall, 27.2% of women with normal cervical cytology had a positive HPV-test. There was a U-shaped evolution of prevalence with women over 50 years having the highest HPV prevalence, followed by the 20 to 29 years group. The most prevalent HPV genotypes were HPV 53(3.52%), 68(3.33%), 52(2.59%), 31(2.22%) and 16 (1.85%). The proportion of HPV 16 among HPV-infected women was 6.8%.ConclusionsHPV prevalence in cytologically normal women was very high. The most prevalent genotypes were very different from what is usually described in the world, and notably in South America.

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Survival of patients with invasive cervical cancer in French Guiana, 2003-2008

Cited by 13 publications

References 5 publications

Screening for cervical cancer in French Guiana: screening rates from 2006 to 2011

Screening for cervical cancer in French Guiana: screening rates from 2006 to 2011

Predictors of abnormal cytology among HPV-infected women in remote territories of French Guiana

The singular epidemiology of HPV infection among French Guianese women with normal cytology

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