Survival of hereditary non-polyposis colorectal cancer patients compared with sporadic colorectal cancer patients

Stigliano, V.; Assisi, D.; Cosimelli, Maurizio; Palmirotta, Raffaele; Giannarelli, Diana; Mottolese, Marcella; Mete, L. Sanchez; Mancini, Raffaello; Casale, V.

doi:10.1186/1756-9966-27-39

Cited by 37 publications

(22 citation statements)

References 31 publications

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“…This finding is consistent with a previous study that among HNPCC patients, a group in which most tumors exhibit MSI-H, the crude 5-year cumulative survival is better than that of patients with sporadic CRC (29). Analysis of the data related to postoperative survival showed no significant difference between EMAST-positive (n=44) and -negative (n=28) groups (P=0.74 by the log-rank test; Fig.…”

Section: Correlation Between the Emast Status And Clinicopathologicalsupporting

confidence: 92%

Microsatellite instability at tetranucleotide repeats in sporadic colorectal cancer in Japan

et al. 2009

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Abstract.Most tumors of patients with Lynch syndrome and a fraction of sporadic colorectal cancers (CRCs) exhibit high levels of microsatellite instability (MSI) at mono-and dinucleotide repeat loci. A different type of instability, elevated microsatellite alterations at selected tetranucleotide repeats (EMAST) has been found in non-colonic cancers. Our previous study demonstrated that EMAST is common in sporadic CRC. Here, we focused on the relationships between EMAST and other genomic instability parameters or clinicopathological features in an unselected series of 88 sporadic CRCs. Of the tumors in the sample, 4 (4.5%) were MSI-high (MSI-H), 9 (10.2%) were MSI-low (MSI-L) and 75 (85.2%) were microsatellite stable. EMAST status was determined using 7 EMAST markers. Fifty-three (60.2%) tumors without MSI-H showed instability at ≥1 EMAST loci. All 4 MSI-H tumors showed instability at several EMAST loci. Instability profiles of MSI-H tumors at EMAST loci were more complex than those of non-MSI-H tumors. A tendency of positive association was observed between MSI-L and EMAST (P=0.023). The frequency of loss of heterozygosity (LOH) for the 14 loci in EMAST-positive tumors was significantly higher than negative tumors (P=0.048). Among the clinicopathological parameters, only tumor location at the distal colon was associated with EMAST-negative tumors (P=0.0084, onetailed). A relatively higher frequency of well-differentiated adenocarcinomas was observed in EMAST tumors as opposed to non-EMAST tumors, though the survival rate was similar. These results suggest that overlapping mechanisms that cause MSI-L, EMAST and LOH in CRCs may exist.

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Section: Correlation Between the Emast Status And Clinicopathologicalsupporting

confidence: 92%

Microsatellite instability at tetranucleotide repeats in sporadic colorectal cancer in Japan

et al. 2009

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“…We did, however, conduct sensitivity analyses assessing the impact of stage adjustment in cases with known stage at diagnosis, and conducted sensitivity analyses adjusting for T-stage and nodal status (i.e., the T and N components of TNM stage) which were known for a larger proportion of cases (84%, N=2757). Because hereditary nonpolyposis colorectal cancer (HNPCC) may be associated with a better prognosis than sporadic disease, 21 and because HNPCC is more likely to be MSI-H and proximally-located than sporadic disease, we also conducted sensitivity analyses excluding cases with germline mutations in one of four DNA mismatch repair genes ( MLH1 , MSH2 , MSH6 , and PMS2 ), which could reflect HNPCC. All analyses were conducted using STATA SE version 11.0 (College Station, Texas).…”

Section: Methodsmentioning

confidence: 99%

Colon and Rectal Cancer Survival by Tumor Location and Microsatellite Instability

Phipps

Lindor

Jenkins

et al. 2013

Diseases of the Colon &Amp; Rectum

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Background Cancers in the proximal colon, distal colon, and rectum are frequently studied together; however, there are biological differences in cancers across these sites, particularly in the prevalence of microsatellite instability. Objective We assessed differences in survival by colon or rectal cancer site, considering the contribution of microsatellite instability to such differences. Design This is a population-based prospective cohort study for cancer survival. Settings This study was conducted within the Colon Cancer Family Registry, an international consortium. Participants were identified from population-based cancer registries in the United States, Canada, and Australia. Patients Information on tumor site, microsatellite instability, and survival after diagnosis was available for 3284 men and women diagnosed with incident invasive colon or rectal cancer between 1997–2002, with ages at diagnosis ranging from 18–74. Main Outcome Measures Cox regression was used to calculate hazard ratios for the association between all-cause mortality and tumor location, overall and by microsatellite instability status. Results Distal colon (hazard ratio=0.59, 95% confidence interval: 0.49–0.71) and rectal cancers (hazard ratio=0.68, 95% confidence interval: 0.57–0.81) were associated with lower mortality than proximal colon cancer overall. Compared specifically to cases with proximal colon cancer exhibiting no/low microsatellite instability, cases with distal colon and rectal cancers experienced lower mortality, regardless of microsatellite instability status; cases with proximal colon cancer exhibiting high microsatellite instability had the lowest mortality. Limitations Study limitations include the absence of stage at diagnosis and cause of death information for all but a subset of study participants. Some case groups defined jointly by tumor site and microsatellite instability status are subject to small numbers. Conclusion Proximal colon cancer survival differs from survival for distal colon and rectal cancer in a manner apparently dependent on microsatellite instability status. These findings support the premise that proximal colon, distal colon, and rectal cancers are clinicopathologically distinct.

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“…According to different studies, 5-year survival of HNPCC probands has been estimated 55-94% in various populations (Stigliano et al, 2008;Haghighi et al, 2009). It was 82.5% in HNPCC-CRC patients versus 56.4% in sporadic ones according to one study in Iran (Haghighi et al, 2009).…”

Section: 4647 Epidemioclinical Features Of Early-onset Colorectal Camentioning

confidence: 99%

Epidemioclinical Feature of Early-Onset Colorectal Cancer at-Risk for Lynch Syndrome in Central Iran

Zeinalian

Chaleshtori²,

Akbarpour³

2015

Asian Pacific Journal of Cancer Prevention

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Survival of hereditary non-polyposis colorectal cancer patients compared with sporadic colorectal cancer patients

Cited by 37 publications

References 31 publications

Microsatellite instability at tetranucleotide repeats in sporadic colorectal cancer in Japan

Microsatellite instability at tetranucleotide repeats in sporadic colorectal cancer in Japan

Colon and Rectal Cancer Survival by Tumor Location and Microsatellite Instability

Epidemioclinical Feature of Early-Onset Colorectal Cancer at-Risk for Lynch Syndrome in Central Iran

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