Epidemioclinical Feature of Early-Onset Colorectal Cancer at-Risk for Lynch Syndrome in Central Iran

Zeinalian, Mehrdad; Chaleshtori, Morteza Hashemzadeh; Akbarpour, Mohammad Javad

doi:10.7314/apjcp.2015.16.11.4647

Cited by 11 publications

(12 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Genetically inherited autosomal disorders such as lynch syndrome increase the risk of colon cancer [44], and it is estimated 10-14% of cases to be at high risk of lynch syndrome-associated colon cancers in Iran [5,6,[45][46][47]. However, we found no study addressed this subject in Golestan province.…”

Section: Discussionmentioning

confidence: 89%

Association Between Heavy Metals and Colon Cancer: An Ecological Study Based on Geographical Information Systems in Northeastern Iran

Kiani

Amin

Bagheri

et al. 2020

Preprint

View full text Add to dashboard Cite

BackgroundExposure to environmental pollutants such as heavy metals has been introduced as a possible contributor to increasing the risk of colon cancer. We aim to explore the associations between heavy metals and the age-standardized incidence rate (ASR) colon cancer in Northeastern Iran.MethodsCancer data were drawn from the population-based cancer registry of Golestan province, Northeastern Iran. The heavy metals’ samples were collected from 69 rice milling plants in the study area. Then, the concentration level of seven heavy metals, including Cadmium, Nickel, Cobalt, Copper, Selenium, Lead, and Zink was measured. The Kriging algorithm was used to interpolate the heavy metals' concentration on the surface of the study area. The exploratory regression analysis was conducted to build the ordinary least squares (OLS) models on every possible combination of the candidate explanatory variables. Finally, the best OLS models were chosen to show the effect of heavy metals on colon cancer.ResultsGenerally, heavy metals were higher in central part of the province. The analyses showed that the high concentration of Cobalt was associated with the high ASR of colon cancer in men. In contrast, the Selenium concentration was higher in areas with lower ASR of colon cancer in men. A significant regression equation for men colon cancer was found (F(4,137)=38.304, P<.000) with an adjusted R2 of 0.77. The predicted ASR of men colon cancer was -58.3581 with the coefficients for Cobalt= 120.329780; Cadmium= 80.603505; Selenium= -6.069037; Nickel= -3.086802; and Zink= -0.405843. The effect of Copper and Lead on men colon cancer was not significant. We did not find a significant model for women colon cancer.ConclusionThere may be a possible negative correlation between selenium concentration and lower risk of colon cancer in men. Furthermore, the higher cobalt concentration may be related to an increased risk of men colon cancer.

show abstract

Section: Discussionmentioning

confidence: 89%

Association Between Heavy Metals and Colon Cancer: An Ecological Study Based on Geographical Information Systems in Northeastern Iran

Kiani

Amin

Bagheri

et al. 2020

Preprint

View full text Add to dashboard Cite

show abstract

“…However, this pattern is more pronounced in Asia than in the Western countries [25,[39][40][41][42][43][44][45]. Recent studies give incidence rates of CRC in patients at 50 years and younger in India [46] and in the central region of Iran [23] at 39% and 25%, respectively. Furthermore, we found that more than 38% of our cases were rst diagnosed with CRC when still under 50 years.…”

Section: Resultsmentioning

confidence: 99%

“…The reasons for the rising incidence and mortality of early-onset CRCs are unclear. Some authors suggest that the growing trend may be related to changing lifestyles, with an increasingly common type of patients characterized by overweight as evidenced by a body mass index (BMI) above 25, low physical activity and diabetes [7,8]. Biologically, CRC in young patients may be different from that seen in patients above 50 years of age.…”

mentioning

confidence: 99%

“…So far, to gain a deeper understanding of this upcoming world-wide health issue, the differences between earlyonset and late-onset CRCs have been investigated in various populations and ethnics [16,17]. While the pathogenesis of former in the context of hereditary syndromes, as well as sporadic cases, have been widely studied in the western part of the world [18][19][20][21][22], epidemiological data and pathogenesis of this type of cancer is generally lacking in countries situated in the East [23]. Moreover, there are considerable diversities regarding tumour location, gender preference and survival [24][25][26][27][28], which need to be speci ed for the region.…”

mentioning

confidence: 99%

See 1 more Smart Citation

Colorectal Cancer in Iran: A Retrospective, Comparative Study of Early-onset and Late-onset Cases in north-eastern Iran based on the Iranian Hereditary Colorectal Cancer Registry

Hoseini

Rahmatinejad

Goshayeshi

et al. 2021

Preprint

View full text Add to dashboard Cite

Background: Generally, the incidence rate of colorectal cancer (CRC) is increasing among young patients (aged <49 years), while the reasons for the rising incidence are unclear. Indicative variables, such as tumour location, gender preference and genetic preponderance have not been followed up in a consistent manner. The current study was primarily conducted to improve the hereditary CRC screening programme by assessing the demographic and pathological characteristics of early-onset CRC compared to late-onset CRC in northeast Iran. Methods: This retrospective study was carried out over a three-year follow-up period (2014-2017) and included 562 CRC patients in three Mashhad City hospital laboratories in north-eastern Iran. We applied comparative analysis of pathological and familial features together with information on the presence of genetic mismatch repair-deficiency in relation to final patient status (surviving versus deceased cases). Analyses using R studio software were performed on early-onset CRC (n=222) and late-onset CRC (n=340) groups produced by division at the age of 50 years. Results: From an age-of-onset point of view, the distribution between the genders differed with females showing a higher proportion of early-onset CRC compared to men (56% vs. 44 %) , while the late-onset CRC disparity was less pronounced (48% vs. 52%). The mean age of all participants was 55.6 ± 14.8 years, while it was 40.3 ± 7.3 years for early-onset CRC and 65.1 ± 9.3 years for late-onset CRC. With respect to anatomical tumour location (distal, rectal, and proximal), the frequencies were 61%, 28% and 11%, respectively, but the variation did not reach statically significance. There was a dramatic difference with regard to the history of CRC in second-degree relatives (SDR) and that of the combination of first-degree relatives and SDR (p=0.001 and p=0.03, respectively). Expression of the MLH1 and PMS2 genes were significantly different between survivors and deceased, however this finding was not observed with regard to the MSH6 and the MSH2 genes. Conclusion: The variation of demographic, pathological and genetic characteristics of CRC between early-onset and late-onset cancers of this kind emphasizes the need for a well-defined algorithm to identify high-risk patients.

show abstract

“…Although breast and prostate cancers have not considered as Lynch-associated cancers in some studies, there are some lines of evidence suggesting that MMR de ciency could increase the incidence of these cancers in MMR de cient carriers (24)(25)(26)(27). We have recently evaluated breast and prostate cancers as the rst and the third frequent extracolonic cancers among Iranian MMR de cient families in a case series study [39].…”

Section: Resultsmentioning

confidence: 99%

A Novel Stop-Gain Mutation in MSH2 Gene Among a Persian Family Fulfilling Classic Amsterdam Criteria for Lynch Syndrome

Miar¹,

Narrei²,

Tabatabaiefar³

et al. 2021

Preprint

Self Cite

View full text Add to dashboard Cite

Purpose Lynch syndrome is the most common hereditary cancer syndromes due to a germline mutation in one of the mismatch-repair (MMR) genes. It results in early-onset colorectal cancer (CRC) and other Lynch-associated cancers in an autosomal dominant pattern. In this article, a new pathogenic variant in a Persian family with familial CRCs and positive Amsterdam II criteria has been described. Methods IHC-MMRs was done on tissue sections from tumor and its adjacent healthy tissue of the proband. Microsatellite instability (MSI) testing was also performed on DNA extracted from tumor and healthy tissue using Promega kit. Next Generation Sequencing (NGS) was finally done on genomic DNA of the proband using a 12-gene-panel including MMR genes. Variant filtering and prioritization were done using bioinformatics tools. Co-segregation analysis was used to evaluate the explored pathogenic variant. Results The proband was a 38-year woman at-diagnosis affected with CRC located in the sigmoid colon. The family history of cancer was observed in three successive generations. IHC was absent for MSH2 and MSH6, and MSI-High was reported from MSI testing. NGS analysis explored a new stop gained codon mutation on the first exon of MSH2 gene as a substitution of A to G MSH2: c.364A > T which was pathogenic according to the variant interpretation guidelines of American College of Medical Genetics and Genomics. Conclusion Revealing of a more obvious molecular feature of Lynch-syndrome among Iranian populations could lead to identification of at-risk people for early care and prevention of cancer.

show abstract

Epidemioclinical Feature of Early-Onset Colorectal Cancer at-Risk for Lynch Syndrome in Central Iran

Cited by 11 publications

References 37 publications

Association Between Heavy Metals and Colon Cancer: An Ecological Study Based on Geographical Information Systems in Northeastern Iran

Association Between Heavy Metals and Colon Cancer: An Ecological Study Based on Geographical Information Systems in Northeastern Iran

Colorectal Cancer in Iran: A Retrospective, Comparative Study of Early-onset and Late-onset Cases in north-eastern Iran based on the Iranian Hereditary Colorectal Cancer Registry

A Novel Stop-Gain Mutation in MSH2 Gene Among a Persian Family Fulfilling Classic Amsterdam Criteria for Lynch Syndrome

Contact Info

Product

Resources

About