Survival of breast cancer patients after subsequent term pregnancy: “Healthy mother effect”

Sankila, Risto; Heinävaara, Sirpa; Hakulinen, Timo

doi:10.1016/s0002-9378(94)70290-x

Cited by 224 publications

(161 citation statements)

References 10 publications

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“…The first population based studies showed that the relative risk of pregnancy after breast cancer on survival and distant metastases is 0.2 and 0.4 respectively (88,89). The subgroup analysis of term deliveries, preterm deliveries and abortions after breast cancer treatment showed that none worsens the prognosis even after considering age at diagnosis, tumor size, lymph node metastasis, time from prior pregnancy to breast cancer diagnosis and time from breast cancer diagnosis to last pregnancy (9,86 (10).…”

Section: The Effect Of Pregnancy After Breast Cancer Treatment On mentioning

confidence: 99%

“…The subgroup analysis of term deliveries, preterm deliveries and abortions after breast cancer treatment showed that none worsens the prognosis even after considering age at diagnosis, tumor size, lymph node metastasis, time from prior pregnancy to breast cancer diagnosis and time from breast cancer diagnosis to last pregnancy (9,86 (10). Table 3 summarizes the case control and population based studies calculating survival rate considering whether the patient got pregnant after breast cancer treatment (9,10,86,(88)(89)(90)(91)(92)(93)95). In most case control studies, providing a multivariate analysis including presence of estrogen receptor, age at diagnosis, tumor size, histological grade, pregnancy after breast cancer treatment has a favourable effect on 5 to 10 years of survival (88,(93)(94)(95).…”

Section: The Effect Of Pregnancy After Breast Cancer Treatment On mentioning

confidence: 99%

“…Table 3 summarizes the case control and population based studies calculating survival rate considering whether the patient got pregnant after breast cancer treatment (9,10,86,(88)(89)(90)(91)(92)(93)95). In most case control studies, providing a multivariate analysis including presence of estrogen receptor, age at diagnosis, tumor size, histological grade, pregnancy after breast cancer treatment has a favourable effect on 5 to 10 years of survival (88,(93)(94)(95). This favourable effect of pregnancy on survival after breast cancer treatment was explained with the `healthy mother effect` which was first proposed by Sankila et al stating that women who can plan pregnancy are more likely to have local disease without recurrence during follow up and who are in a good general health (88).…”

Section: The Effect Of Pregnancy After Breast Cancer Treatment On mentioning

confidence: 99%

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Pregnancy associated breast cancer and pregnancy after breast cancer treatment

Döğer¹,

Çalışkan²,

Mallmann³

2011

J Turkish German Gynecol Assoc

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Breast cancer is one of the most common cancers diagnosed during pregnancy and its frequency is increasing as more women postpone their pregnancies to their thirties and forties. Breast cancer diagnosis during pregnancy and lactation is difficult and complex both for the patient and doctors. Delay in diagnosis is frequent and treatment modalities are difficult to accept for the pregnant women. The common treatment approach is surgery after diagnosis, chemotherapy after the first trimester and radiotherapy after delivery. Even though early stage breast cancers have similar prognosis, advanced stage breast cancers diagnosed during pregnancy and lactation have poorer prognosis than similar stage breast cancers diagnosed in non-pregnant women. Women who desire to become pregnant after treatment of breast cancer will have many conflicts. Although the most common concern is recurrence of breast cancer due to pregnancy, the studies conducted showed that pregnancy has no negative effect on breast cancer prognosis. In this review we search for the frequency of breast cancer during pregnancy, the histopathological findings, risk factor, diagnostic and treatment modalities. We reviewed the literature for evidence based findings to help consult the patients on the outcome of breast cancer diagnosed during pregnancy and lactation, and also inform the patients who desire to become pregnant after breast cancer according to current evidences. (J Turkish-German Gynecol Assoc 2011; 12: 247-55)

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Section: The Effect Of Pregnancy After Breast Cancer Treatment On mentioning

confidence: 99%

Section: The Effect Of Pregnancy After Breast Cancer Treatment On mentioning

confidence: 99%

Section: The Effect Of Pregnancy After Breast Cancer Treatment On mentioning

confidence: 99%

See 1 more Smart Citation

Pregnancy associated breast cancer and pregnancy after breast cancer treatment

Döğer¹,

Çalışkan²,

Mallmann³

2011

J Turkish German Gynecol Assoc

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“…Quite unexpectedly, data from these trials suggest that subsequent pregnancy does not have a detrimental effect on survival or local relapse [7]. Even more, there is a suggestion that pregnancy might have a protective effect [8,9]. Several theories have been posed to explain this finding including patient selection, the healthy mother effect [9], alloimmunization [10] and estrogen-induced apoptosis of the endocrine responsive breast cancer cells [11].…”

Section: Pregnancy After Breast Cancermentioning

confidence: 99%

“…Even more, there is a suggestion that pregnancy might have a protective effect [8,9]. Several theories have been posed to explain this finding including patient selection, the healthy mother effect [9], alloimmunization [10] and estrogen-induced apoptosis of the endocrine responsive breast cancer cells [11]. Pregnancy is now generally deemed safe 1-2 years following breast cancer diagnosis [7].…”

Section: Pregnancy After Breast Cancermentioning

confidence: 99%

Breast-feeding after breast cancer: if you wish, madam

Azim

Bellettini²,

Gelber

et al. 2008

Breast Cancer Res Treat

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Breast cancer is the most common malignant tumor-affecting women during the child bearing period. With the rising trend in delaying pregnancy later in life, the issue of subsequent pregnancy and lactation following breast cancer diagnosis has been more frequently encountered. In this context, data is scarce particularly those addressing the issue of lactation. In this review, we discussed different endocrinal, clinical and biological aspects dealing with breast-feeding after breast cancer in an attempt to determine how safe and feasible this approach is.

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Breast Cancer in Pregnancy

Woo

Yu²,

Hurd³

2003

Arch Surg

253

164

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Breast cancer in pregnancy will increase as more women postpone childbearing until later in life. Objective: To review the literature on diagnosis, staging, treatment, and prognosis. Design and Methods: Articles were obtained from MEDLINE (1966-present) using the keywords breast, cancer, carcinoma, and pregnancy. Additional articles were sought using the references of those obtained. A total of 171 articles were found, 125 in English. More than 100 were reviewed, including 7 prospective and 40 retrospective studies, 6 case reports, and at least 47 review articles on various aspects of pregnancy and cancer. Data extraction was performed by 1 reviewer. Results: Diagnostic delays are shorter than in the past but remain common. Mammography has a high falsenegative rate during pregnancy. Biopsy or needle aspi

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Survival of breast cancer patients after subsequent term pregnancy: “Healthy mother effect”

Cited by 224 publications

References 10 publications

Pregnancy associated breast cancer and pregnancy after breast cancer treatment

Pregnancy associated breast cancer and pregnancy after breast cancer treatment

Breast-feeding after breast cancer: if you wish, madam

Breast Cancer in Pregnancy

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