Survival of Alzheimer's Disease Patients in Korea

Go, Seok Min; Lee, Kang Soo; Seo, Sang Won; Chin, Juhee; Kang, Sohi; Moon, So Young; Na, Duk L.; Cheong, Hae-Kwan

doi:10.1159/000347133

Cited by 29 publications

(49 citation statements)

References 46 publications

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“…Therefore, the severe phase could be slightly longer.) Survival from onset of symptoms was about 12.3 years, which is similar to the Korean results of 12.6 years …”

Section: Life Expectancy and Dementiasupporting

confidence: 83%

“…There are more research publications about life expectancy on AD than VD. From the published data, there are conflicting estimates of the duration of survival of AD patients, which ranges from 3 to 12 years . A low overall survival of AD patients of only 3.3 years was reported in 2001 by Wolfson et al .…”

Section: Life Expectancy and Dementiamentioning

confidence: 99%

“…A recent report from Korea analyzed survival rates in 724 consecutive AD patients from a memory disorder clinic in a tertiary hospital in Seoul . The overall median survival from the time of diagnosis was 9.3 years.…”

Section: Life Expectancy and Dementiamentioning

confidence: 99%

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The natural history of dementia

et al. 2014

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This review summarizes studies on the natural history of dementia with a focus on Alzheimer's disease and vascular dementia. Understanding the course of dementia is important not only for patients, caregivers, and health professionals, but also for health policy-makers, who have to plan for national resources needed in the management of an increasing number of dementia cases. From the available published data, the life expectancy of elderly people with dementia is shorter than that of non-demented elderly. Reports on survival after a diagnosis of dementia vary from 3 to 12 years. The wide variation is partly due to the diagnostic criteria used in the studies and the sites where they were conducted (i.e. hospitals, clinics, or homes). There is an apparent difference in survival between Alzheimer's disease patients with onset of illness before 75 years and those after 75 years: the younger patients have a longer life expectancy. However, there are conflicting data on survival (in years) comparing male and female patients and comparing patients of different ethnicities. For vascular dementia, published papers on life expectancy vary between 3 to 5 years. Vascular dementia appears to have a poorer prognosis than Alzheimer's disease. The stages of severity of dementia were compared in a follow-up of a sample of Alzheimer's disease patients in Singapore, and the mean duration of the mild phase (clinical dementia rating 1) was 5.6 years, the moderate phase (clinical dementia rating 2) was 3.5 years, and the severe phase (clinical dementia rating 3) was 3.2 years. At the various phases of the disease, the demand on health-care services and economic cost are different.

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“…Therefore, the severe phase could be slightly longer.) Survival from onset of symptoms was about 12.3 years, which is similar to the Korean results of 12.6 years …”

Section: Life Expectancy and Dementiasupporting

confidence: 83%

Section: Life Expectancy and Dementiamentioning

confidence: 99%

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The natural history of dementia

et al. 2014

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“…Survival times according to these factors are shown in online supplementary table 4. Factors that affect survival time in AD patients have been described in a prior study from our group [15]: older age at onset, male sex, presence of DM and lower cognitive status at diagnosis were factors that were related to poor survival time in AD.…”

Section: Resultsmentioning

confidence: 64%

Survival in Subcortical Vascular Dementia: Predictors and Comparison to Probable Alzheimer's Disease in a Tertiary Memory Clinic Population

Go¹,

Seo²,

Kim³

et al. 2015

Dement Geriatr Cogn Disord

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Background: Subcortical vascular dementia (SVaD) is one of the most common dementias, after Alzheimer's disease (AD) dementia. Few survival analyses in SVaD patients have been reported. Methods: The dates and causes of death of 146 SVaD and 725 AD patients were included. We used the Cox proportional hazards model to compare survival between SVaD and AD patients and to explore possible factors related to survival of SVaD patients. Results: The median survival time after the onset of SVaD (109 months) was shorter than that recorded for AD (152 months). The most common cause of death in SVaD was stroke (47.1%). Factors associated with shorter survival in SVaD were late onset, male sex, worse baseline cognition, absence of hypertension and a family history of stroke. Conclusions: Stroke prevention may be important in SVaD treatment because 47.1% of SVaD patients died of stroke. A family history of stroke and absence of hypertension were associated with a shorter survival in SVaD, suggesting the existence of genetic or unknown risk factors.

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“…질병에 대한 지식의 부족과 편견은 조기선별을 지연시키는 가장 큰 원인이다 [3,4]. 하지만 일반 성인 및 노인들은 물론이고 이들을 직접 접촉하는 돌봄 제공자나 건강관리요원들 조차 알츠하이머병 관련 지식은 부족한 것으로 보고되었다 [2,5,6].…”

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