Survival in soft tissue sarcoma: Prognostic variables identified by multivariate analysis

Rööser, Bo; Attewell, Robyn; Berg, Nils O.; Rydholm, Anders

doi:10.3109/17453678709146391

Cited by 56 publications

(5 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The histological grade, the size of the tumour, its depth, and surgical margin proved to be the significant prognostic factors (Table IV), as has previously been shown in many other studies. 5,6,11,19,[26][27][28][29][30][31] Neither local recurrence at initial presentation nor after definitive surgery at our hospitals had prognostic significance in the multivariate analysis.…”

Section: Resultsmentioning

confidence: 99%

“…Inadequate surgery is still frequently performed, however, before proper consultation with specialist centres, resulting in a high incidence of local recurrence, which has long been considered to be an ominous prognostic sign. 5,[10][11][12][13] Several recent reports, however, have suggested that local recurrence does not adversely affect survival, [14][15][16][17][18][19] but Pisters et al 30 have recently indicated that patients with locally recurrent disease when first seen are at increased risk of subsequent local recurrence and of death from the disease. As Evans 9 has pointed out, there are two patterns of local recurrence: first, that following a limited operation with an inadequate surgical margin, so-called 'local persistence', and secondly local recurrence after radical surgery with an adequate surgical margin.…”

Section: Discussionmentioning

confidence: 99%

“…[5][6][7] Even after a radical operation, there is local recurrence in about 5% to 10% of patients, although the impact of this on survival remains uncertain. 8,9 Some previous reports 5, [10][11][12][13] indicate that this is a grave prognostic sign, but others disagree. [14][15][16][17][18][19] Evans 9 has recently suggested the importance of distinguishing two manifestations of locally recurrent disease stating that "Local recurrence following radical surgery is a grave sign, but local recurrence following limited surgery, which is labelled 'local persistence' is often an innocent event".…”

mentioning

confidence: 97%

See 2 more Smart Citations

Influence of Local Recurrence on the Prognosis of Soft-Tissue Sarcomas

Ueda¹,

Yoshikawa²,

Mori³

et al. 1997

The Journal of Bone and Joint Surgery. British volume

View full text Add to dashboard Cite

We have investigated the significance of local recurrence on survival in 173 patients with localised soft-tissue sarcomas of the limbs and of the trunk.The overall survival rates at five and ten years were 75.2% and 68.0%, respectively. After definitive surgery at our hospitals, there was local recurrence in 25 patients (14.5%). After inadequate operations elsewhere, there was a higher incidence of late local recurrence (28.3%), in comparison with those with primary tumours treated by us (9.0%), or patients referred to us immediately after inadequate surgery elsewhere (10.2%). Because of small numbers these differences in the survival rates were not statistically significantly different.Univariate survival analysis showed that local recurrence after definitive surgery (p = 0.006) together with the histological grade (p = 0.0002), the size of the tumour (p = 0.002), its depth in relation to deep fascia (p = 0.003), and the surgical margin (p = 0.0001) were the significant prognostic factors. Local recurrence at the initial presentation did not affect survival. Multivariate analysis showed that local recurrence after definitive surgery also lost its apparent prognostic significance.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 97%

See 1 more Smart Citation

Influence of Local Recurrence on the Prognosis of Soft-Tissue Sarcomas

Ueda¹,

Yoshikawa²,

Mori³

et al. 1997

The Journal of Bone and Joint Surgery. British volume

View full text Add to dashboard Cite

show abstract

“…Rooser et al [42] demonstrated marginal excision, tumour necrosis and extracompartmental extension to be the most important risk factors for local recurrences.…”

Section: Detection Of Recurrences and Distinction From Posttherapeutimentioning

confidence: 99%

The role of magnetic resonance imaging in the evaluation of bone tumours and tumour-like lesions

et al. 2014

View full text Add to dashboard Cite

Teaching Points• When a lesion is indeterminate or shows signs of aggressiveness, MRI is indicated.• When MRI does not lead to a diagnosis, biopsy is indicated.• MRI is superior to the other imaging modalities in detecting bone marrow lesions.• MRI is very helpful in local staging and surgical planning.• MRI is used in assessing the response to neoadjuvant therapy, restaging and post-therapeutic follow-up.

show abstract

“…Favourable outcome of the disease not only requires early diagnosis but also rather aggressive first line treatment combining extensive surgery, radiotherapy and in selected cases also chemotherapy. Currently, prognosis estimations are based on the histological grade, size and the depth of the tumour (Collin et al, 1987;Rööser et al, 1987;Alvegård et al, 1989). Meanwhile, new prognostic factors are actively being searched for, mainly in the field of tumour biology.…”

mentioning

confidence: 99%

The adhesion molecule CD44v6 is associated with a high risk for local recurrence in adult soft tissue sarcomas

et al. 2001

View full text Add to dashboard Cite

Summary In many malignant diseases the expression levels of CD44 and its splice variant v6 (CD44v6) have been associated with the prognosis. The purpose of this study was to investigate the clinical significance of CD44 in adult soft tissue sarcomas (STS). 133 STS patients with a limb or superficial trunk tumour treated at the Helsinki University Central Hospital in 1987-1993 with a median follow-up time of 68 months were included in this study. The expression of CD44 and CD44v6 was determined immunohistochemically on paraffin-embedded tumour samples. 95% of the tumours expressed CD44 and CD44v6 was detected in 57%. Strong CD44 expression was associated with low grade (P = 0.04) and small tumour size (P = 0.02). In diploid tumours the CD44 expression was correlated with low S-phase fraction (P = 0.001). High expression of both, CD44 in general as well as that of CD44v6, predicted a higher risk for local recurrence (CD44: P = 0.01 and CD44v6: P = 0.05). Low CD44v6 content of the primary tumour correlated with poor survival (P = 0.02). Determining the expression of CD44 or CD44v6 in a primary STS could be a valuable tool for selecting the group of patients who might benefit from intensified local tumour treatment.

show abstract

Survival in soft tissue sarcoma: Prognostic variables identified by multivariate analysis

Cited by 56 publications

References 13 publications

Influence of Local Recurrence on the Prognosis of Soft-Tissue Sarcomas

Influence of Local Recurrence on the Prognosis of Soft-Tissue Sarcomas

The role of magnetic resonance imaging in the evaluation of bone tumours and tumour-like lesions

The adhesion molecule CD44v6 is associated with a high risk for local recurrence in adult soft tissue sarcomas

Contact Info

Product

Resources

About