Survival in patients under 45 years with squamous cell carcinoma of the oral tongue

Manuel, Salles; Raghavan, Sriniket; Pandey, Manoj; Stolzmann, Paul

doi:10.1054/ijom.2002.0271

Cited by 67 publications

(75 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Our present study showed a male preponderance (66.0% vs 34.0%) in OSCC which is in agreement with some earlier studies (Manuel et al, 2003;Sherin et al, 2008;Chang et al, 2013). While increasing number of studies suggest that the proportion of oral cavity cancer cases in women increased worldwide especially among young white individuals in western countries (Patel et al, 2011;Durr et al, 2013).…”

Section: Discussionsupporting

confidence: 93%

“…Ganly et al in the US (2012) evaluated a cohort with a higher proportion of T1 and T2 tumors young patients experienced better survival. Manuel et al (Manuel et al, 2003) furthermore found that lymphatic invasion was associated with decreased survival. The 5-year OS in patients with a pathologically negative node was significantly higher compared to patients with histologically positive nodes (P=0.006).…”

Section: Discussionmentioning

confidence: 97%

See 1 more Smart Citation

Survival Analysis of Oral Squamous Cell Carcinoma in a Subgroup of Young Patients

Fan

Zheng²,

Mao³

et al. 2014

Asian Pacific Journal of Cancer Prevention

View full text Add to dashboard Cite

Oral squamous cell carcinoma (OSCC) is predominantly a disease of middle-aged men with long-term exposure to tobacco and alcohol. An increasing trend has been reported at a younger age worldwide. Clinical records of 100 patients under the age of 45 years treated specifically for oral cavity SCC in our hospital during a 10-year period were retrospectively analyzed to calculate the survival rates. An obvious male predominance coincided with smoking trend among Chinese young individuals and female patients were more likely to have no traditional risk factors such as smoking or drinking. The 5-year overall survival rate and disease-free survival rate were 61.0% and 75.5%, respectively, consistent with other published series over the decade showing a relatively better survival among the young. No significant differences clearly correlated with outcome when comparing non-smokers non-drinkers to ever-smokers and ever drinkers (P>0.05). Overall survival rate and disease free survival rate was found to be significantly higher in patients with early-stage disease than with advanced stage disease (P=0.001, P=0.009 respectively). The strong influence of clinical stage on prognosis emphasizes the importance of early diagnosis and treatment of oral malignancies for this unique clinical subgroup.

show abstract

Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 97%

Survival Analysis of Oral Squamous Cell Carcinoma in a Subgroup of Young Patients

Fan

Zheng²,

Mao³

et al. 2014

Asian Pacific Journal of Cancer Prevention

View full text Add to dashboard Cite

show abstract

“…It is in agreement with the literature (6,14) however ,some authors believe that oral cancer in young adults has more aggressive behavior and poorer prognosis and some other studies showed similar survival among younger and older patients (6,7). Late diagnosis and treatment of OSCC will result in severe debilitation due to mutilating surgery, often associated with extensive destruction of oral and facial structures, so early diagnosis and proper management is needed to achieve a better quality of life and higher survival rate.…”

Section: Discussionsupporting

confidence: 89%

“…These conditions have been suggested as predisposing factors for OSCC (15). The most common clinical presentation of OSCC in our patients was exophytic lesion, but in the study of kuriakose et al and Manuel et al ulceroproliferative lesions were more common (6,14). This may be related to different habits of different cultures.…”

Section: Discussionmentioning

confidence: 48%

“…Some researchers believe that familial history is more significant than tobacco and alcohol consumption in developing of OSCC in the young (1,8). Viral infections (13), deficiency of fresh fruits and vegetables in diet (14) nutritional deficiencies (particularly of iron and folic acid) (15), have been suggested as the risk factors of OSCC in young people in the literature. In this research there were no evidence of family history or HPV infection in our cases, but an interesting finding was a history of gastric bypass because of over weight in patient No.12, done one year before OSCC presentation.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Clinical and histopathological analysis of oral Squamous cell carcinoma of young patients in Mashhad, Iran: A retrospective study and review of literature

Falaki¹,

Dalirsani²,

Pakfetrat³

et al. 2011

Med Oral

View full text Add to dashboard Cite

Objectives: Oral Squamous cell carcinoma (OSCC) is primarily a disease that mainly occurs in males in their sixth and seventh decades of life and is rare in young adults. Study Design: In this retrospective study, records of patients under the age of 40, with the diagnosis of OSCC in the Oral Medicine Department of Mashhad Dental Faculty during the past 13 years were analyzed. Their socioeconomic data, demographic, clinical and histopathological characteristics, risk factors, familial history were assessed and applicable studies and case reports in the literatures were reviewed. PCR (Polymerase chain reaction) analysis was also done for detection of human papilloma virus (HPV). Results: From 158 cases of OSCC diagnosed in our centre, 21 patients were younger than 40 years. Most of them were young men (12 cases). There was no significant risk factor in this group. The most common site of involvement was the tongue. The most common clinical presentation was exophytic lesion with ulcer. No HPV DNA was detected in these patients. Conclusion: Characteristics of OSCC in young patients are different from older age group. Major risk factors (smoking and alcohol consumption and HPV) were not etiologic factors for OSCC in young patients in our province.

show abstract

Squamous Cell Carcinoma of the Oral Tongue in the Pediatric Age Group

Morris¹,

Patel²,

Shah³

et al. 2010

Arch Otolaryngol Head Neck Surg

View full text Add to dashboard Cite

Objective To compare outcomes of a pediatric cohort of patients compared with a matched cohort of adult patients, all diagnosed as having squamous cell carcinoma (SCC) of the oral tongue. Outcomes of oral cancer in pediatric patients have not been studied, to our knowledge. Design Retrospective matched-pair cohort study. Setting Memorial Sloan-Kettering Cancer Center, New York, New York. Patients A total of 10 pediatric and 40 adult patients diagnosed as having SCC of the oral tongue. Main Outcome Measures Overall survival (OS), disease-specific survival (DSS), and recurrence-free survival (RFS). Results The 5-year OS was equivalent in the 2 groups: 70% in the pediatric group and 64% in the adult group (P=.97). The 5-year DSS was also equivalent: 80% in the pediatric group and 76% in the adult group (P=.90). The 5-year RFS was 70% in the pediatric group and 78% in the adult group (P=.54). Conclusions When pediatric and adult patients were matched for sex, tobacco use history, TNM status, surgical procedure, and adjuvant radiotherapy, outcomes for OS, DSS, and RFS were equivalent. Pediatric patients with SCC of the oral tongue should be treated similarly to adult patients.

show abstract

Survival in patients under 45 years with squamous cell carcinoma of the oral tongue

Cited by 67 publications

References 20 publications

Survival Analysis of Oral Squamous Cell Carcinoma in a Subgroup of Young Patients

Survival Analysis of Oral Squamous Cell Carcinoma in a Subgroup of Young Patients

Clinical and histopathological analysis of oral Squamous cell carcinoma of young patients in Mashhad, Iran: A retrospective study and review of literature

Squamous Cell Carcinoma of the Oral Tongue in the Pediatric Age Group

Contact Info

Product

Resources

About