Survival in Finnish Centenarians in Relation to Apolipoprotein E Polymorphism

Louhija, Jukka; Viitanen, Matti; Agüero‐Torres, Hedda; Tilvis, Reijo S.

doi:10.1046/j.1532-5415.2001.49199.x

Cited by 28 publications

(20 citation statements)

References 7 publications

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“…The explanation for our novel finding, i.e., that the ε2-allele could benefit EL in the Italian and Japanese population, and specifically favor healthy attainment of EL in the Italian cohort, is less apparent and warrants further research. The ApoE ε2-allele has previously been reported to be more frequent in centenarians (Blanche et al, 2001;Louhija et al, 1994;Schachter et al, 1994;Seripa et al, 2006) than in younger people, but others found no differences (Asada et al, 1996;Capurso et al, 2004;Feng et al, 2011;Louhija et al, 2001;Panza et al, 1999). A meta-analysis considering only studies of centenarians published before 2004 gave a point estimate of 1.50 (95%CI, 1.27-1.78) for ε2-allele frequency in centenarians vs. younger controls (Lewis and Brunner, 2004).…”

Section: Discussionmentioning

confidence: 99%

“…However, others found no association of this variant with EL in Japanese (Asada et al, 1996), Finnish (Louhija et al, 2001) or Southern-Italian centenarians (Capurso et al, 2004). Concurrently, the ApoE ε2-allele has been reported to be more frequent in centenarians (Blanche et al, 2001;Louhija et al, 1994;Schachter et al, 1994;Seripa et al, 2006) than in younger people, but others found no differences (Asada et al, 1996;Feng et al, 2011;Louhija et al, 2001;Panza et al, 1999). A meta-analysis reported a point estimate of 1.50 [95% confidence intervals (CI): 1.27, 1.78] and 0.49 (95%CI: 0.41, 0.58) for the frequency of ε2 and ε4-alleles, respectively, in centenarians vs. younger controls, but only studies published before 2004 were included in the review (Lewis and Brunner, 2004).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

ApoE gene and exceptional longevity: Insights from three independent cohorts

Garatachea

Emanuele

Calero

et al. 2014

Experimental Gerontology

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This article appeared in a journal published by Elsevier. The attached copy is furnished to the author for internal non-commercial research and education use, including for instruction at the authors institution and sharing with colleagues.Other uses, including reproduction and distribution, or selling or licensing copies, or posting to personal, institutional or third party websites are prohibited. The ApoE gene is associated with the risk of Alzheimer or cardiovascular disease but its influence on exceptional longevity (EL) is uncertain. Our primary purpose was to determine, using a case-control design, if the ApoE gene is associated with EL. We compared ApoE allele/genotype frequencies among the following cohorts: cases (centenarians, most with 1 + major disease condition; n = 163, 100-111 years) and healthy controls (n = 1039, 20-85 years) from Spain; disease-free cases (centenarians; n = 79, 100-104 years) and healthy controls (n = 597, age 27-81 years) from Italy; and cases (centenarians and semi-supercentenarians, most with 1+ major disease condition; n = 729, 100-116 years) and healthy controls (n = 498, 23-59 years) from Japan. Our main findings were twofold. First, the ε4-allele was negatively associated with EL in the three cohorts, with the following odds ratio (OR) values (adjusted by sex) having been found: 0.55 (95% confidence interval (CI): 0.33, 0.94), P = 0.030 (Spain); 0.41 (95%CI: 0.18, 0.99), P = 0.05 (Italy); and 0.35 (95%CI: 0.26, 0.57), P b 0.001 (Japan). Second, although no association was found in the Spanish cohort (OR = 1.42 (95%CI: 0.89, 2.26), P = 0.145), the ε2-allele was positively associated with EL in the Italian (OR = 2.14 (95%CI: 1.18, 3.45), P = 0.01) and Japanese subjects (OR = 1.81 (95%CI: 1.25, 2.63), P = 0.002). Notwithstanding the limitations of case-control designs, our data suggest that the ApoE might be a candidate to influence EL. The ε4-allele appears to decrease the likelihood of reaching EL among individuals of different ethnic/geographic origins. An additional, novel finding of our study was that the ε2-allele might favor EL, at least in the Italian and Japanese cohorts.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

ApoE gene and exceptional longevity: Insights from three independent cohorts

Garatachea

Emanuele

Calero

et al. 2014

Experimental Gerontology

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“…This allele has also been associated with coronary heart disease (12, 13) and cerebrovascular disease (14,15) in some studies but not in others (16,17). In addition, ApoE has been studied in the context of mortality, but the results of these studies are controversial (18)(19)(20)(21)(22)(23)(24).…”

Section: Introductionmentioning

confidence: 99%

Apolipoprotein E polymorphism distribution in an elderly Brazilian population: the Bambuí Health and Aging Study

Fuzikawa

Peixoto

Taufer

et al. 2007

Braz J Med Biol Res

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Apolipoprotein E (ApoE) is one of the most extensively studied genes in the context of aging, but there are few population-based studies on ApoE polymorphism in the elderly in developing countries. The objective of the present study was to assess ApoE allele and genotype distribution in a large elderly community-based sample and its association with age, sex and skin color. Participants included 1408 subjects (80.8% of all residents aged ≥60 years) residing in Bambuí city, MG, Brazil. The DNA samples were subjected to the polymerase chain reaction amplification, followed by the restriction fragment length polymorphism technique, with digestion by HhaI. Analysis was carried out taking into consideration the six ApoE genotypes (ε3/ ε3, ε3/ε4, ε2/ε3, ε4/ε4, ε2/ε4, and ε2/ε2), the three ApoE alleles, and the number of ApoE4 alleles for each individual. The ε3 allele predominated (80.0%), followed by ε4 (13.5%) and ε2 (6.5%). All six possible genotypes were observed, the ε3/ε3 genotype being the most frequent (63.4%). This distribution was similar to that described in other western populations. Sex was not associated with number of ApoE4 alleles. Black skin color was significantly and independently associated with the presence of two ApoE4 alleles (age-sex adjusted OR = 7.38; 95%CI = 1. 93-28.25), showing that the African-Brazilian elderly have a high prevalence of the ε4 allele, as observed in blacks from Africa. No association between number of ApoE4 alleles and age was found, suggesting the absence of association of ApoE genotype with mortality in this population.

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“…However, different studies have reported mixed results in concerning the issue of longevity, with some documenting null findings for APOE e4 and longevity [59,60], and others showing negative associations in subgroups only [61].…”

Section: Apolipoprotein E (Apoe)mentioning

confidence: 99%

“…In our study we expect that the number of survival in both gender will be similar, but as we observed that the deviations (differences between observed and expected), were different. When we compare the survival rate among both gender at age group (60)(61)(62)(63)(64)(65)(66)(67)(68)(69)(70)(71)(72)(73)(74) in 1995 vs. (73)(74)(75)(76)(77)(78)(79)(80)(81)(82)(83)(84)(85)(86)(87) in 2008, we observed more survival among males comparing to females (p=0.003), this means that the rate of mortality was higher among females, and the rate of survival was higher among males (p=0.003). Indeed, in 2008 we expected to have 86 males alive but we were surprised to find 108 males alive, in contrary we expected to have more females alive (157), but we only found 135 alive at 2008.…”

Section: Follow Upmentioning

confidence: 99%

Human Longevity: Nature versus Nurture, Survival versus Mortality~!2010-04-29~!2010-06-30~!2010-08-31~!

Bowirrat¹

2010

TOALTMEDJ

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Numerous studies were published, investigating the associations of ApoE and ACE polymorphisms with longevity. In 1995, we conducted based cross-sectional study among 823 elderly Arab residents in Israel for studying the prevalence and genetics of dementia of Alzheimer's type (DAT). Epidemiological and genes results of (ApoE + ACE) were reported The ApoE frequency was the lowest in the world and no association was found between ACE and DAT. During 2008, we conducted a follow up study looking for survival and mortality rate among the same participants to endeavor if there is any relationship between genes and longevity. The total mortality rate among both genders after thirteen years was 66.34%, and the survival subjects of 88 years or older were 34 persons only out of the initial number 270 in 1995 (34/270 = 12.6%). We used the Chi-Square test to examine the null hypothesis (no difference between observed and expected results): When we compare the survival rate among both sexes in age group (60-74) in 1995 vs. age group (73-87) in 2008. We observed statistically significant high survival rate among males (p=0.003) comparing to females in the same age groups. In contrary, at advanced age, when we compare the survival rate in age group (75-85+) in 1995 vs. age group (88-98+) in 2008, we observed high and significant survival rate among females (p=0.033).Conclusion: High rate of mortality was observed among females in age groups (60-74) in1995 and age group (73-87) in 2008, and high rate of mortality at advanced age was observed among males at advanced age group (75-85+) in 1995 and age group (88-98+) in 2008. More females live longer than men and no association was found between ApoE, ACE genes and longevity, that seems that longevity is exceedingly dependent on other genes in addition to the environmental factors.

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Survival in Finnish Centenarians in Relation to Apolipoprotein E Polymorphism

Cited by 28 publications

References 7 publications

ApoE gene and exceptional longevity: Insights from three independent cohorts

ApoE gene and exceptional longevity: Insights from three independent cohorts

Apolipoprotein E polymorphism distribution in an elderly Brazilian population: the Bambuí Health and Aging Study

Human Longevity: Nature versus Nurture, Survival versus Mortality~!2010-04-29~!2010-06-30~!2010-08-31~!

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