Survival and prognosticators of node-positive cervical cancer patients treated with radical hysterectomy and systematic lymphadenectomy

Abstract

More than two LNM sites and adenocarcinoma were independent prognostic factors for node-positive patients with cervical cancer.

Incorporation of the number of positive lymph nodes leads to better prognostic discrimination of node-positive early stage cervical cancer

“…In addition, the prognostic value of the number of positive LNs was not affected by postoperative RT. In a study by Hosaka et al also found that patients with > 2 positive LNs experienced poorer survival in 108 patients with FIGO IB-IIIB cervical cancer [18]. However, it is unknown whether postoperative CCRT could influence the prognostic value of the number of positive LNs.…”

Locoregional Spread and Survival of Stage IIA1 versus Stage IIA2 Cervical Cancer

“…Systematic pelvic lymphadenectomy is an important part of surgical treatment for early-stage cervical cancer. The mean or median number of pelvic nodes removed varied from 13-65 in previous reports (Sakuragi, 2007;Hosaka et al, 2011). In the EORTC-GCG study, removal of more than 11 pelvic nodes was suggested as one of the quality indications for pelvic lymphadenectomy (Verleye et al, 2009).…”

Significance of the Absolute Number and Ratio of Metastatic Lymph Nodes in Predicting Postoperative Survival for the International Federation of Gynecology and Obstetrics Stage IA2 to IIA Cervical Cancer

“…3 In the Gynecologic Oncology Group's (GOG) surgical-pathology study of patients with IB cervical cancer, the 3-year disease-free interval was 74% for those with positive nodes versus 86% for node-negative patients. 4 Hosaka et al 5 reported that the survival of patients with cervical cancer with more than 2 lymph node metastasis sites was significantly worse than the survival of patients with 1 or 2 lymph node metastasis sites.…”