Survival and prognostic factors in patients with small bowel carcinoid tumour

Landerholm, Kalle; Zar, Niklas; Andersson, Roland; Falkmer, Sture; Järhult, Johannes

doi:10.1002/bjs.7649

Cited by 71 publications

(61 citation statements)

References 22 publications

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“…Patients with localized small bowel carcinoid tumors have a far better prognosis than those with metastases, as previously established (20,22). It was therefore intriguing that the majority of localized tumors contained CARTexpressing cells when CART tumor expression is associated with worse survival.…”

Section: Discussionmentioning

confidence: 99%

“…In accordance with previous studies (20,22,23), the disease stage was defined as localized when the tumor was confined to the bowel wall, regional with either local tumor invasion of the adjacent mesentery or regional lymph node metastases, and distant with metastases elsewhere, including the peritoneum other than that covering the adjacent mesentery. These 3 groups correspond to stages I-IIB, IIIA and IIIB, and IV, respectively, in the recently introduced tumor-node-metastasis (TNM) classification (24,25).…”

Section: Staging and Cause Of Deathmentioning

confidence: 92%

“…All patients in J€ onk€ oping county (population 338,000) diagnosed with carcinoid tumor in the jejunum or ileum, including the ileocecal valve, from 1960 to 2005, were identified in 2 previous studies (19,20). In brief, patients were initially found through the Swedish Cancer Registry and the local cancer registry.…”

Section: Patient Cohortmentioning

confidence: 99%

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Expression of Cocaine- and Amphetamine-Regulated Transcript Is Associated with Worse Survival in Small Bowel Carcinoid Tumors

Landerholm

Shcherbina

Falkmer

et al. 2012

Clinical Cancer Research

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Purpose: Cocaine-and amphetamine-regulated transcript (CART) peptide exerts several regulatory functions acting both as neurotransmitter and hormone. We recently showed that CART is expressed in various neuroendocrine tumors, including small bowel carcinoids. The main objective of the present study was to examine whether CART expression is associated with survival in patients with small bowel carcinoid. Secondary aims were to assess whether CART expression is associated with other tumor characteristics or clinical symptoms.Experimental Design: Specimens from 97 patients with small bowel carcinoids were examined for CART expression using immunohistochemistry. A CART score was introduced on the basis of the proportion of CART immunoreactive cells. On inclusion, specimens were examined by routine histopathologic methods and detailed clinical patient data were retrieved. The effect of CART on cell viability was assessed in vitro using two intestinal tumor cell lines.

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Section: Discussionmentioning

confidence: 99%

Section: Staging and Cause Of Deathmentioning

confidence: 92%

See 1 more Smart Citation

Expression of Cocaine- and Amphetamine-Regulated Transcript Is Associated with Worse Survival in Small Bowel Carcinoid Tumors

Landerholm

Shcherbina

Falkmer

et al. 2012

Clinical Cancer Research

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“…Localized and regionally restricted (Stage I-III) Si-NENs have an excellent prognosis after radical surgical treatment. The importance of achieving R0 resection is therefore emphasized [94,95]. To limit the extent of small intestinal resection, lymphatic mapping has been suggested to be helpful, but it is not a standardized procedure and therefore not generally recommended [96,97].…”

Section: Resection Of Localized and Regional Disease (Stage I-iii)mentioning

confidence: 99%

ENETS Consensus Guidelines Update for Neuroendocrine Neoplasms of the Jejunum and Ileum

et al. 2016

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“…Their 5-year overall survival is approximately 60%, 2,3 and their median survival is approximately 7 years. 1 Prognostic features of JINETs include TNM stage, [4][5][6] World Health Organization (WHO) grade, 7,8 tumor multifocality, 9 vascular invasion, 10 mesenteric tumor deposits, 11 and completeness of mesenteric tumor resection. 4,5 Rarely, JINETs come to clinical attention because of tumor-induced intestinal ischemia, and the resected surgical specimen shows intestinal ischemic necrosis (IIN) in the nonneoplastic small intestine.…”

mentioning

confidence: 99%

Jejunoileal Neuroendocrine Tumors Complicated by Intestinal Ischemic Necrosis Are Associated With Worse Overall Survival

Landau

Wisniewski

Davison

2016

Archives of Pathology &Amp; Laboratory Medicine

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Context.-Jejunoileal neuroendocrine tumors (JINETs) are slow-growing, malignant tumors that are often associated with protracted survival, despite their frequent presentation at an advanced stage. A subset of JINETs is complicated by intestinal ischemic necrosis (IIN), which leads to their initial clinical presentation.Objective.-To assess the effect of IIN on overall survival in patients with JINETs.Design.-Ten JINETs with IIN during a 14-year period and a control group of 52 JINETs without IIN were identified retrospectively. The hematoxylin-eosin slides and gross descriptions were reviewed, and pathologic features were assessed. Overall survival was compared between the 2 groups using the Kaplan Meier method and Cox proportional hazards model.Results.-At 1 year postresection, only 40% (4 of 10) of the patients with IIN were alive, whereas 94% (49 of 52) of those without IIN were alive (P , .001). Patients with IIN were significantly older than those without IIN (median, 83 years versus 65.5 years, P ¼ .001). By univariate Cox proportional hazards regression, IIN was associated with a 4.30-fold increased risk of death (95% confidence interval 1.75-10.56; P ¼ .001). When controlling for age, advanced stage (stage III or IV), tumor grade, and synchronous carcinoma in a multivariate analysis, IIN showed a trend toward prognostic significance (2.31-fold increased risk of death; 95% confidence interval, 0.85-6.27; P ¼ .10).Conclusions.-The pathologic identification of tumorassociated IIN portends a worse overall survival among patients with JINETs.

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Survival and prognostic factors in patients with small bowel carcinoid tumour

Abstract: Age, disease stage and complete resection were identified as independent prognostic factors for survival in patients with small bowel carcinoid tumours. The importance of achieving R0 resection is therefore emphasized.

Cited by 71 publications

References 22 publications

Expression of Cocaine- and Amphetamine-Regulated Transcript Is Associated with Worse Survival in Small Bowel Carcinoid Tumors

Expression of Cocaine- and Amphetamine-Regulated Transcript Is Associated with Worse Survival in Small Bowel Carcinoid Tumors

ENETS Consensus Guidelines Update for Neuroendocrine Neoplasms of the Jejunum and Ileum

Jejunoileal Neuroendocrine Tumors Complicated by Intestinal Ischemic Necrosis Are Associated With Worse Overall Survival

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