Abstract:Context.-Jejunoileal neuroendocrine tumors (JINETs) are slow-growing, malignant tumors that are often associated with protracted survival, despite their frequent presentation at an advanced stage. A subset of JINETs is complicated by intestinal ischemic necrosis (IIN), which leads to their initial clinical presentation.Objective.-To assess the effect of IIN on overall survival in patients with JINETs.Design.-Ten JINETs with IIN during a 14-year period and a control group of 52 JINETs without IIN were identi… Show more
“…Additionally, in describing pN2 criteria, the AJCC emphasizes mesenteric tumor deposits or nodal disease that "encase[s] the superior mesenteric vessels." This likely refers to the morbidity and mortality associated with tumor-induced fibrosis around the mesenteric vessels [17]. While many tumor deposits in our study involved mesenteric vessels, we did not evaluate this aspect of the new N-category; to our knowledge, the specific impact of metastatic disease involving superior mesenteric vessels has not been assessed in rigorous multivariable analysis.…”
Mesenteric tumor deposits are an adverse prognostic factor for small intestinal well-differentiated neuroendocrine tumors. Per the American Joint Committee on Cancer (AJCC) Cancer Staging Manual (eighth edition), any mesenteric tumor deposit larger than 2 cm signifies pN2 disease. This criterion has not been critically evaluated as a prognostic factor for small intestinal neuroendocrine tumors, nor have multifocality or histologic features of mesenteric tumor deposits. We evaluated 70 small intestinal neuroendocrine tumors with mesenteric tumor deposits for lesional contour, sclerosis, inflammation, calcification, entrapped blood vessels, and perineural invasion. Ki67 proliferative indices of the largest mesenteric tumor deposit from each case were calculated, and number of tumor deposits and size of the largest deposit were recorded. Associations between these factors (along with patient age, primary tumor Ki67 index, and AJCC stage) and development of liver metastases and overall survival were assessed. Median mesenteric tumor deposit size was 1.5 cm (range: 0.2-7.0 cm); median deposit number was 1 (range: 1-13). Primary and tumor deposit Ki67 indices within a given patient were discordant in 40% of cases but showed similar hazard ratios for disease-specific survival. Size of tumor deposits had no significant effect on prognosis, whether analyzed on a continuous scale or dichotomized using the recommended 2 cm cutoff. In contrast, increasing number of deposits was associated with poor prognosis, with multiple deposits conferring an 8.19-fold risk of disease-specific death compared to a single deposit (P = 0.049). Morphologic features of deposits had no prognostic impact. Size of mesenteric tumor deposits does not affect prognosis in small intestinal neuroendocrine tumor patients; instead, deposit multifocality is associated with shorter disease-specific survival and should be incorporated into future staging criteria.
“…Additionally, in describing pN2 criteria, the AJCC emphasizes mesenteric tumor deposits or nodal disease that "encase[s] the superior mesenteric vessels." This likely refers to the morbidity and mortality associated with tumor-induced fibrosis around the mesenteric vessels [17]. While many tumor deposits in our study involved mesenteric vessels, we did not evaluate this aspect of the new N-category; to our knowledge, the specific impact of metastatic disease involving superior mesenteric vessels has not been assessed in rigorous multivariable analysis.…”
Mesenteric tumor deposits are an adverse prognostic factor for small intestinal well-differentiated neuroendocrine tumors. Per the American Joint Committee on Cancer (AJCC) Cancer Staging Manual (eighth edition), any mesenteric tumor deposit larger than 2 cm signifies pN2 disease. This criterion has not been critically evaluated as a prognostic factor for small intestinal neuroendocrine tumors, nor have multifocality or histologic features of mesenteric tumor deposits. We evaluated 70 small intestinal neuroendocrine tumors with mesenteric tumor deposits for lesional contour, sclerosis, inflammation, calcification, entrapped blood vessels, and perineural invasion. Ki67 proliferative indices of the largest mesenteric tumor deposit from each case were calculated, and number of tumor deposits and size of the largest deposit were recorded. Associations between these factors (along with patient age, primary tumor Ki67 index, and AJCC stage) and development of liver metastases and overall survival were assessed. Median mesenteric tumor deposit size was 1.5 cm (range: 0.2-7.0 cm); median deposit number was 1 (range: 1-13). Primary and tumor deposit Ki67 indices within a given patient were discordant in 40% of cases but showed similar hazard ratios for disease-specific survival. Size of tumor deposits had no significant effect on prognosis, whether analyzed on a continuous scale or dichotomized using the recommended 2 cm cutoff. In contrast, increasing number of deposits was associated with poor prognosis, with multiple deposits conferring an 8.19-fold risk of disease-specific death compared to a single deposit (P = 0.049). Morphologic features of deposits had no prognostic impact. Size of mesenteric tumor deposits does not affect prognosis in small intestinal neuroendocrine tumor patients; instead, deposit multifocality is associated with shorter disease-specific survival and should be incorporated into future staging criteria.
“…The presence of advanced MF associated with intestinal ischemia has been recently identified as a poor prognostic factor for OS [ 5 ]. Venous ischemia due to superior mesenteric vein involvement is more often encountered as compared to its arterial counterpart, resulting in venous stasis, abdominal pain, aggravated diarrhea, ascites, malabsorption and malnutrition [ 73 ]. In advanced cases, MF surrounding LN metastases in the root of the mesentery may lead to shrinkage and fixation of it to the retroperitoneum that can cause in turn obstruction of the small intestine, duodenum and/or transverse colon.…”
Mesenteric fibrosis (MF) constitutes an underrecognized sequela in patients with small intestinal neuroendocrine neoplasms (SI-NENs), often complicating the disease clinical course. The aim of the present systematic review, carried out by Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) methodology, is to provide an update in evolving aspects of MF pathogenesis and its clinical management in SI-NENs. Complex and dynamic interactions are present in the microenvironment of tumor deposits in the mesentery. Serotonin, as well as the signaling pathways of certain growth factors play a pivotal, yet not fully elucidated role in the pathogenesis of MF. Clinically, MF often results in significant morbidity by causing either acute complications, such as intestinal obstruction and/or acute ischemia or more chronic conditions involving abdominal pain, venous stasis, malabsorption and malnutrition. Surgical resection in patients with locoregional disease only or symptomatic distant stage disease, as well as palliative minimally invasive interventions in advanced inoperable cases seem clinically meaningful, whereas currently available systemic and/or targeted treatments do not unequivocally affect the development of MF in SI-NENs. Increased awareness and improved understanding of the molecular pathogenesis of MF in SI-NENs may provide better diagnostic and predictive tools for its timely recognition and intervention and also facilitates the development of agents targeting MF.
“…Somatostatin receptor analogues are used as immunotherapy if distant metastasis. However, different somatostatin receptor subtypes represent a challenge in the management (9,10) .…”
Background: Neuroendocrine neoplasms NENs represent rare malignancies in the elderly group. They comprise a heterogeneous group including neuroendocrine tumors NETs, neuroendocrine carcinomas NECs and mixed neuroendocrine non-neuroendocrine neoplasms MiNENs.
Case presentation: A rare case of NET presenting as a bleeding rectal polyp.
Conclusion: we aimed to summarize the diagnostic approach for such a rare entity.
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