Survival and Glycemic Control Outcomes Among Patients with Coexisting Pancreatic Cancer and Diabetes Mellitus

Abstract

Aim:We aimed to determine the effect of diabetes mellitus (DM) on survival in pancreatic cancer and effects of pancreatic cancer on glycemic control in DM.Materials & methods:Patients with pancreatic cancer from 2007 to 2015, with and without DM, were matched 1:1. We compared characteristics between the groups and assessed 2-year survival with Kaplan–Meier analysis.Results:In patients with DM, hemoglobin A1c decreased significantly over time (p = 0.01). In survival analysis, 2-year overall survival estimates were 15% (95% CI: 8–24%) for DM patients versus 26% (95% CI: 17–36%) for non-DM patients (p = 0.55). The hazard ratio for matched pairs was 1.15 (95% CI: 0.75–1.77; p = 0.51).Conclusion:DM did not decrease survival in pancreatic cancer. Pancreatic cancer did not affect glycemic control.

Survival and glycemic control in patients with colorectal cancer and diabetes mellitus.

“…For patients and healthcare providers responsible for management of DM, it is encouraging that glycemic control did not worsen, at least over the year timeframe analyzed here. This observation is similar to that of our previous analyses of other solid organ malignancies [15][16][17][18]. Although HbA 1c was available for only about half of the DM patients, it did not increase over 12 months.…”

“…The statistical analyses conducted were similar to those used for our previous studies [15][16][17][18]. Patient demographic and clinical characteristics were compared between patients with colorectal cancer with and without DM.…”

“…Additional data about patient-centered outcomes are needed for the interaction of DM and cancer. We previously investigated the effects of several different solid tumors (breast, prostate and lung) and DM on patient outcomes and care [15][16][17][18]. In all of these matched case-control studies, DM did not impact patients' short-term survival, and the cancer did not affect glycemic control in patients with DM.…”

“…Case selection was similar to that described for previous studies [15][16][17][18]. Mayo Clinic Institutional Review Board approval was obtained for this retrospective, case-control study.…”

Survival and Glycemic Control in Patients with Coexisting Lymphoma and Diabetes: A Case–Control Analysis

“…Previous case–control studies of patients at a large cancer institute in the southwestern USA have shown that diabetes does not worsen survival for patients with solid organ cancers and that solid organ cancers do not worsen glycemic control. We have studied this relationship in pancreatic cancer [ 15 ], gastroesophageal cancer [ 16 ], lung cancer [ 17 ], breast cancer [ 18 ], prostate cancer [ 15 ], colorectal cancer [ 19 ] and melanoma [ 20 ]. Gastroesophageal cancer was the only cancer in which a greater risk of death was seen in patients with than without diabetes [ 16 ].…”