Survival and Glycemic Control in Patients with Coexisting Lymphoma and Diabetes: A Case–Control Analysis

Abstract

Aim: We examined the effect of diabetes on survival in patients with lymphoma and the effect of lymphoma on glycemic control. Patients & methods: Patients with lymphoma with and without diabetes (2005–2016) were retrospectively identified and matched 1:1. Overall survival and progression-free survival were estimated by the Kaplan–Meier method. Hemoglobin A1c (HbA1c) and glucose levels during the year after cancer diagnosis were compared by mixed models. Results: For patients with diabetes, mean HbA1c during the year after lymphoma diagnosis was 6.7%. Estimated 5-year progression-free survival for patients with versus without diabetes was 63% (95% CI: 53–76%) versus 58% (95% CI: 46–71%) (p = 0.42). Conclusion: Lymphoma and its treatment did not affect glycemic control. Diabetes did not decrease lymphoma-specific survival.

Survival and Glycemic Control in Patients With co-existing Squamous Cell Carcinoma and Diabetes Mellitus

“…The statistical analyses conducted were similar to those used for our previous studies [13][14][15][16][17][18][19][20]. Patients with DM (cases) and without DM (controls) were compared on the basis of patient demographic and clinical variables.…”

“…Our findings found statistical significance compared with the other multiple case-control studies done at our institution. The authors had previously investigated the effect of solid tumors -breast, lung, prostate, colorectal, pancreatic, gastric, esophageal, lymphoma and melanoma and DM on patient outcome measures [13][14][15][16][17][18][19][20]. In all these case-control studies, DM did not affect survival of patients.…”

“…Previous studies from our institution have evaluated the relationship between patients with DM and several malignancies including melanoma, pancreatic cancer, lung cancer, breast cancer, prostate cancer, gastroesophageal cancer, colorectal cancer and lymphoma [13][14][15][16][17][18][19][20]. Only gastroesophageal cancer has shown a decrease in survival in patients with DM compared with those without [18].…”