Survival and characteristics of pediatric salivary gland cancer: A systematic review and meta‐analysis

Garset‐Zamani, Martin; Grønhøj, Christian; Jensen, Jan H.; Buchwald, Christian von; Charabi, Birgitte; Hjuler, Thomas

doi:10.1002/pbc.27543

Cited by 20 publications

(36 citation statements)

References 37 publications

(261 reference statements)

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“…13 Two SEER database studies (Surveillance, Epidemiology, and End Results) and a meta-analysis summarized the clinical characteristics of pediatric patients with salivary gland carcinomas, emphasizing that a large proportion were low-grade tumors; however, the authors did not compare the patients by risk group, and variables such as T stage and margin status were not uniformly reported. 1,14,15…”

Section: Discussionmentioning

confidence: 99%

Rethinking the Definition of High Risk in Pediatric Salivary Gland Carcinoma

Acharya¹,

Sinard

Rangel

et al. 2021

Otolaryngol.--head neck surg.

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Objective Indications for adjuvant radiation in pediatric salivary gland carcinoma rely on high-risk criteria extrapolated from adult data. We sought to determine whether adult-derived high-risk criteria were prognostic in children aged ≤21 years or young adults aged 22 to 39 years. Study Design Cross-sectional analysis of a hospital-based national registry. Setting Patients were identified from the National Cancer Database between 2004 and 2015. Methods High-risk criteria were defined as adenoid cystic histology, intermediate/high grade, T3/T4, positive margins, and/or lymph node involvement. Exact matching was used to adjust for differences in baseline characteristics between pediatric and young adult patients. Results We identified 215 pediatric patients aged ≤21 years, 317 patients aged 22 to 30 years, and 466 patients aged 31 to 39 years. Within the pediatric cohort, there was no significant difference in overall survival (OS) between low- and high-risk groups (5-year OS, 100% vs 98.5%; P = .29). In contrast, within the young adult cohorts, there was a significant difference in OS between low- and high-risk groups in patients aged 22 to 30 years (5-year OS, 100% vs 96.1%; P = .01) and 31 to 39 years (5-year OS, 100% vs 88.5%; P < .001). When high-risk patients were matched 1:1 on high-risk criteria and race, pediatric patients were associated with better OS than those aged 22 to 30 years ( P = .044) and those aged 31 to 39 years ( P = .005). Conclusion Children have excellent OS, irrespective of adult-derived high-risk status. These findings underscore the need to understand how age modifies clinicopathologic risk factors.

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Section: Discussionmentioning

confidence: 99%

Rethinking the Definition of High Risk in Pediatric Salivary Gland Carcinoma

Acharya¹,

Sinard

Rangel

et al. 2021

Otolaryngol.--head neck surg.

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“…Complete surgery is the mainstay of treatment, regardless of the tumor type and location 2,21,30,33,35,36,67–69 (Level III; Grade A), and represents a major prognostic factor 9,70–74 . Excision biopsy or tumor enucleation should be avoided due to the risk of tumor seeding (Level III; Grade E).…”

Section: Treatment Recommendationsmentioning

confidence: 99%

Salivary gland carcinoma in children and adolescents: The EXPeRT/PARTNER diagnosis and treatment recommendations

Surun

Schneider

Ferrari

et al. 2021

Pediatric Blood & Cancer

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Salivary gland carcinomas (SGCs) are rare during childhood and adolescence. Consequently, no standardized recommendations for the diagnosis and therapeutic management of pediatric SGC are available, and pediatric oncologists and surgeons generally follow adult guidelines. Complete surgical resection with adequate margins constitutes the cornerstone of treatment. However, the indications and modalities of adjuvant therapy remain controversial and may be challenging in view of the potential long‐term toxicities in the pediatric population. This paper presents the consensus recommendations for the diagnosis and treatment of children and adolescents with SGCs, established by the European Cooperative Study Group for Pediatric Rare Tumors (EXPeRT) within the EU‐funded PARTNER project (Paediatric Rare Tumours Network ‐ European Registry).

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“…Major nerve involvement was an independent prognostic factor for poor PFS and DMFS, while a time from surgery to RT >30 days resulted in worse PFS and DMFS. A previous study showed clear tendencies for worsening effects of poor differentiation in SCC and high grade in MEC (14). Other research has shown that high-grade tumor histology is a highly significant predictor of shorter survival in SGC, irrespective of histological subtype (15).…”

Section: Discussionmentioning

confidence: 89%

Oncological outcomes of patients with salivary gland cancer treated with surgery and postoperative intensity-modulated radiotherapy: a retrospective cohort study

Zang¹,

Chen²,

Huang³

et al. 2022

Quant Imaging Med Surg

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Background: Salivary gland cancer (SGC) is relatively rare and constitutes a variety of histological subtypes. Previously published studies of SGC patients suggest that postoperative radiation using conventional radiotherapy (RT) or 3-dimensional (3D) conformal radiotherapy may have led to suboptimal oncological outcomes. Methods:We identified 60 patients with major SGC treated with surgery followed by postoperative intensity-modulated radiotherapy (IMRT). Data for overall survival (OS), progression-free survival (PFS), locoregional relapse-free survival (LRRFS), distant metastasis-free survival (DMFS), prognostic factors, and treatment-related toxicities were analyzed. Survival was analyzed using the Kaplan-Meier method and compared using the log-rank test.

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Survival and characteristics of pediatric salivary gland cancer: A systematic review and meta‐analysis

Cited by 20 publications

References 37 publications

Rethinking the Definition of High Risk in Pediatric Salivary Gland Carcinoma

Rethinking the Definition of High Risk in Pediatric Salivary Gland Carcinoma

Salivary gland carcinoma in children and adolescents: The EXPeRT/PARTNER diagnosis and treatment recommendations

Oncological outcomes of patients with salivary gland cancer treated with surgery and postoperative intensity-modulated radiotherapy: a retrospective cohort study

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