Salivary gland carcinoma in children and adolescents: The EXPeRT/PARTNER diagnosis and treatment recommendations

Abstract

Salivary gland carcinomas (SGCs) are rare during childhood and adolescence. Consequently, no standardized recommendations for the diagnosis and therapeutic management of pediatric SGC are available, and pediatric oncologists and surgeons generally follow adult guidelines. Complete surgical resection with adequate margins constitutes the cornerstone of treatment. However, the indications and modalities of adjuvant therapy remain controversial and may be challenging in view of the potential long‐term toxicities in the pediatric population. This paper presents the consensus recommendations for the diagnosis and treatment of children and adolescents with SGCs, established by the European Cooperative Study Group for Pediatric Rare Tumors (EXPeRT) within the EU‐funded PARTNER project (Paediatric Rare Tumours Network ‐ European Registry).

The French FRACTURE database: A way to improve knowledge on management of children with very rare tumors

“…22 The inclusion criteria and the type of tumors registered are very similar to those of the FRACTURE database. 9,27 Finally, all of these studies allowed the EXPeRT group to build and publish care recommendations for the treatment of such rare diseases. 5,8 One specific aim of the national registry is to improve knowledge about cancer epidemiology.…”

“…Several retrospective studies have already been performed with these medical data, improving knowledge of some rare entities 11,13,24–26 . A number of these retrospective studies were performed with the collaboration of other European VRT groups that registered their own patients and within the framework of EXPeRT group 9,27 . Finally, all of these studies allowed the EXPeRT group to build and publish care recommendations for the treatment of such rare diseases 5,8 …”

“…Enough patients have been registered to enable the database to contribute to all collaborative studies undertaken with other European countries and for researchers to perform collaborative retrospective studies. As a result, several collaborative national and international studies have already been finalized using these data, and have even led to recommendations on the diagnosis and treatment of some VRTs, such as pancreatoblastoma or ACC 7–9,27,30,34 . The sustainability of this collection is therefore important, and a regular systematic collaboration between the FRACTURE database and the RNCE register helps to provide a more exhaustive picture of these VRTs and allows research completeness for specific groups of patients.…”

Rare Tumors in Children and Adolescents – the STEP Working Groupʼs Evolution to a Prospective Registry

“…Similar cooperative analyses have also been established for colorectal carcinoma and malignant mela-noma 16 23 . These works have been the basis for establishing closer international collaboration with the funding of the European Commission as part of the ExPO-r-Net (European Expert Pediatric Oncology Reference Network for Diagnostics and Treatment) and partner projects 1 3 5 16 17 26 34 37 . By joining international groups into one registry, it becomes possible to gain further knowledge, especially for very rare tumors.…”

Adenoid cystic carcinoma of the parotid and submandibular glands in children and young adults: A population‐based study

“…[3][4][5] Overall, AdCC is a rare malignancy, with an incidence of approximately 1.2-4.4 cases per million per year in the general population, accounting for approximately 10%-15% of all pediatric salivary gland malignancies. [3][4][5][6][7] Despite early descriptions, literature regarding AdCC's characteristics in children is sparse.…”