Survival Analysis in Endometrial Carcinomas by Type of Surgical Approach: A Matched-Pair Study

Abstract

(1) Background: This study aimed to analyze the impact of surgical approach on survival rates in women diagnosed with endometrial cancer. (2) Methods: A retrospective multicenter cohort of 1382 women diagnosed with EC was performed. A total of 684 (49.5%) women underwent minimally invasive surgery, 233 (34%) underwent robotic-assisted laparoscopy (RAL), 451 (66%) underwent conventional laparoscopy (LPS), and 698 (50.5%) underwent open surgery (OP). Sociodemographic features, tumor characteristics, and survival rates were analyzed in the whole sample and in a matched-pair model. (3) Results: Women operated on by OP were significantly older, presented more comorbidities, and had more aggressive tumors. Disease-free (DFS), overall (OS), and specific survival related to EC (SS) amounts were significantly higher for MIS compared to OP (p < 0.001). When matched by age, body mass index, comorbidities, ASA score, histological type, grade, myometrial invasion, and FIGO stage, 798 patients were selected. DFS, OS, and SS amounts were similar between the MIS and OP groups. (4) Conclusions: The surgical approach for women with EC does not impact DFS or OS amounts when matched by homogeneous groups.

An Integrated Clinical‐MR Radiomics Model to Estimate Survival Time in Patients With Endometrial Cancer

“…The 5‐year overall survival rate of endometrial cancer patients ranges from 74% to 91% 3–5 . To study the survival time of endometrial cancer patients, survival analysis methods have been extensively applied 4–6 . Currently utilized examples include the non‐parametric Kaplan–Meier method and the semi‐parametric Cox's proportional hazards (CPH) method 4,5,7–11 .…”

“…[3][4][5] To study the survival time of endometrial cancer patients, survival analysis methods have been extensively applied. [4][5][6] Currently utilized examples include the non-parametric Kaplan-Meier method and the semi-parametric Cox's proportional hazards (CPH) method. 4,5,[7][8][9][10][11] Based on the CPH model, it is possible to evaluate a single covariate's and/or the combination joint covariates effects on the survival time estimation.…”

“…Endometrial cancer is the most common gynecological cancer, with 417,000 new cases diagnosed globally in 2020 1,2 . The 5‐year overall survival rate of endometrial cancer patients ranges from 74% to 91% 3–5 . To study the survival time of endometrial cancer patients, survival analysis methods have been extensively applied 4–6 .…”

“…[4][5][6] Currently utilized examples include the non-parametric Kaplan-Meier method and the semi-parametric Cox's proportional hazards (CPH) method. 4,5,[7][8][9][10][11] Based on the CPH model, it is possible to evaluate a single covariate's and/or the combination joint covariates effects on the survival time estimation. For instance, a combination of age, cancer histologic grade, socioeconomic factors, and other clinical prognostic factors have been investigated in endometrial cancer survival studies within the framework of the CPH model.…”