Survival after profound hypocalcaemia with tetany complicating severe haemorrhagic acute pancreatitis

Jones, Peter A.

doi:10.1136/pgmj.61.711.43

Cited by 4 publications

(2 citation statements)

References 12 publications

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“…Both signs were positive in the present case. [ 10 ] Death in this case is possibly related with the severity of reaction or delay in starting the rescue treatment. Fine needle aspiration with Gram's stain and bacteriological culture should be carried out in NP to determine status of infection.…”

Section: Discussionmentioning

confidence: 97%

Stavudine induced acute necrotizing pancreatitis with tetany in a pediatric patient

Patel

Barvaliya

Patel³

et al. 2012

Indian J Pharmacol

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A nine year old female patient presented with complaints of severe colicky abdominal pain, vomiting, and tingling with numbness for 3 days. Acute necrotizing pancreatitis associated with tetany due to anti-retroviral therapy was diagnosed. Stavudine was the probable causal agent. Unfortunately, the patient died due to severity of the reaction. High index of suspicion and early withdrawal of the offending drug may prevent further harm in such cases.

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Section: Discussionmentioning

confidence: 97%

Stavudine induced acute necrotizing pancreatitis with tetany in a pediatric patient

Patel

Barvaliya

Patel³

et al. 2012

Indian J Pharmacol

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“…Tetany due to AP is very rare and such patients have extremely poor prognosis [ 28 , 29 ]. There are few case reports of hypocalcemic tetany in AP but the prognostic significance of hypocalcemic tetany has not been studied [ 7 , 20 ].…”

Section: Discussionmentioning

confidence: 99%

Hypocalcemic tetany: a simple bedside marker of poor outcome in acute pancreatitis

Chhabra

Rana

Sharma

et al. 2016

aog

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BackgroundHypocalcemia is a marker of poor prognosis in acute pancreatitis (AP) but the prognostic significance of hypocalcemic tetany in patients with AP has not been studied. We aimed to determine the prognostic significance of hypocalcemic tetany in patients with AP.MethodsConsecutive patients of AP who presented within 7 days of symptoms were included. Serum calcium levels were measured on admission and the patients were divided into two groups based on the presence (group 1) or absence of hypocalcemia (group 2). Chvostek and Trousseau signs were sought in all patients with hypocalcemia and the outcome measures were compared between patients with normocalcemia, asymptomatic and symptomatic hypocalcemia (tetany). The outcome parameters assessed were persistent organ failure (POF), need for intervention, and mortality.ResultsOf 105 patients (53 male; mean age 37.34±12.62 years), 37 (35.2%) had hypocalcemia (group 1) and 68 (64.8%) had normal corrected serum calcium levels (group 2). Patients with hypocalcemia had significantly higher frequency of POF, mortality and need for intervention (P<0.05). Twelve of 37 (32.4%) patients with hypocalcemia had tetany. Patients with tetany had significantly lower serum corrected calcium and ionized calcium levels compared with patients with asymptomatic hypocalcemia (P<0.05). Patients with tetany had significantly higher mortality rates compared with patients with asymptomatic hypocalcemia (100% vs. 8%; P=0.00001) as well as POF (100% vs. 32%; P=0.000006).ConclusionPresence of hypocalcemic tetany in AP patients bears a poor prognosis and is associated with increased mortality.

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Non-infective Acute Pancreatitis

Cruickshank¹,

Benbow

1995

Pathology of the Pancreas

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Survival after profound hypocalcaemia with tetany complicating severe haemorrhagic acute pancreatitis

Cited by 4 publications

References 12 publications

Stavudine induced acute necrotizing pancreatitis with tetany in a pediatric patient

Stavudine induced acute necrotizing pancreatitis with tetany in a pediatric patient

Hypocalcemic tetany: a simple bedside marker of poor outcome in acute pancreatitis

Non-infective Acute Pancreatitis

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