The cystadenomas were of two types: 1 Tumours with small loculi lined by cubical epithelium, in which there was little secretion of mucus by the epithelium but abundant mucoid stroma. There were six of these tumours and we have no evidence of malignant change in this type. 2 Tumours with relatively large cystic spaces filled with mucus and lined by tall, mucus-secreting epithelium. There were eight of these, and the possibility of malignant transformation in this type of tumour is indicated by the finding that in three cases of cystadenocarcinoma two appeared to have been preceded by simple mucus-secreting cystadenomas.Signs of recent or old haemorrhage were common in both types of cystadenoma and also in the cystadenocarcinomas.

No abstract

SYNOPSISThe clinical records and preserved specimens of 111 cases of primary malignant disease of the liver have been analysed. All were diagnosed in the Merseyside area, chiefly in Liverpool and Birkenhead, and all but nine were Europeans. Necropsy was done in 89.The tumours consisted of 108 carcinomas, two sarcomas, and one mixed tumour. Liver cell carcinoma was nearly four times more frequent than carcinoma of the intrahepatic bile ducts. Both types were commoner in males, the difference between the sexes being greater in the case of liver cell carcinoma. Predisposing conditions included portal cirrhosis, haemochromatosis, and cystic malformations of bile ducts. The gross and microscopic appearances are described and the pathological effects discussed. Liver cell carcinoma tends to invade and permeate veins within the liver but seems, nevertheless, to remain limited to the liver for longer than carcinoma of the intrahepatic bile ducts. Liver cell carcinoma is more characteristic microscopically. The commonest occupation among the male cases was seafarer.

No abstract

No abstract