Survival after laryngectomy: a review of 133 patients with laryngeal carcinoma

Abstract

Survival trends in survival for laryngeal cancer in Europe are varied. Five-year survival varied around 60-64% but numbers below 50% have been commonly reported. The aim of this study was to assess the factors influencing survival in patients with laryngeal cancer in our region. A total of 128 male and 5 female patients with larynx cancer (91 glottic and 42 supraglottic) were treated at Patras University Hospital between March 1992 and August 2004. Except 3, all were smokers and 56 (41%) heavy alcohol users. Postsurgical staging showed that most had been classified at stages III (38%) and IV (49%). By histology, 31 tumors were classified as poorly differentiated, 78 as moderately differentiated and 23 as well differentiated. All patients underwent laryngectomy with extension of the procedure where appropriate. Also, a total of 45 patients received adjuvant therapy (either chemotherapy or radiotherapy). Farmers, construction workers, professional drivers and mechanics and coffee shop and bar employees account for more than 70% of patients. Results showed that 64 (48.1%) patients died during the follow-up, 58 (43.6%) of them died from cause related to their disease. With a median follow-up of 25 months, the 5-year disease-free survival (DFS) was 53% and the 5-year overall survival (OS) was 45%. Significant prognostic factors for OS included patient age, advanced staging, heavy alcohol use and poor tumor differentiation while for DFS affected mainly by poor tumor differentiation. We conclude that the disease stage at presentation, tumor grade and alcohol consumption prove to be important predictors for the OS as well as the DFS in our series.

Cáncer de cabeza y cuello en Uruguay. Análisis de sobrevida en dos centros de referencia

“…La sobrevida global a cinco años para los estadios tempranos (I y II) varía de 80% para orofaringe y laringe a 45% para hipofaringe. En estadios tardíos (III y IV) la sobrevida se encuentra entre 50% para orofaringe y 25% para hipofaringe (8,10) . En nuestra serie la sobrevida del cáncer de laringe fue estadísticamente superior cuando se comparó con los otros sitios agrupados, este resultado puede ser consecuencia del alto porcentaje de pacientes con tumores glóticos.…”

Laringectomía total ampliada en carcinoma laríngeo avanzado T4a

“…Acorde a las características tumorales la sobrevida acumulada es similar a la comunicada en la literatura internacional, donde se señala que los factores más importantes que afectan la sobrevida son la edad del paciente, la etapifi cación y diferenciación tumoral y los márgenes quirúrgicos 7,16 .…”

“…En tumores glóticos T1 y T2 la cirugía y la radioterapia tienen excelentes resultados, con una sobrevida a cinco años de 80 a 90%, mientras que para las lesiones T3 y T4 la sobrevida es de 50 a 60% 6,7 . Según la clasificación del American Joint Committee on Cancer, los tumores de glotis en estadio T4a son aquellos que invaden a través de la superfi cie externa del cartílago tiroides y/o invaden distintos tejidos alrededor de la laringe (como por ejemplo la traquea, partes blandas del cuello incluyendo musculatura extrínseca profunda de la lengua, tiroides o esófago) 8 ; en este grupo de pacientes con enfermedad más avanzada está indicada la laringectomía total asociada a una disección cervical bilateral y está indicada la tiroidectomía total o hemitiroidectomía en aquellos casos donde existe compromiso transglótico, tumores subglóticos y tumores con extensión subglótica mayor a 10 mm 9 .…”

Recombinant hirudin suppresses the viability, adhesion, migration and invasion of Hep-2 human laryngeal cancer cells

“…Laryngeal carcinoma (LC) is a common head and neck malignancy and accounts for ~2.4% of newly diagnosed malignancies worldwide every year (1,2). Surgery, chemotherapy and radiation therapy are the current treatment modules for laryngeal cancer (3)(4)(5).…”