Survival after diagnosis of cancer of the oral cavity

Sargeran, Katayoun; Murtomaa, Heikki; Safavi, Seyed Mohammadreza; Vehkalahti, Miira M.; Teronen, Olli

doi:10.1016/j.bjoms.2007.11.004

Cited by 74 publications

(69 citation statements)

References 17 publications

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“…When assessing overall survival in OTSCC patients, it is important to consider the impact of tumour stage. Previous studies in many different types of cancers have shown that tumour size and patient survival are correlated (Sargeran et al, 2007;Kim et al, 2008). In this study, we therefore examined whether Ki-67 expression by stage impacts overall survival in OTSCC.…”

Section: Discussionmentioning

confidence: 99%

Ki-67 expression predicts locoregional recurrence in stage I oral tongue carcinoma

et al. 2008

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Oral tongue squamous cell carcinoma (OTSCC) is an aggressive cancer associated with poor prognosis. Methods for determining the aggressiveness of OTSCC from analysis of the primary tumour specimen are thus highly desirable. We investigated whether genomic instability and proliferative activity (by means of Ki-67 activity) could be of clinical use for prediction of locoregional recurrence in 76 pretreatment OTSCC paraffin samples (stage I, n ¼ 22; stage II, n ¼ 33; stage III, n ¼ 8; stage IV, n ¼ 13). Eleven surgical tumour specimens were also analysed for remnants of proliferative activity after preoperative radiotherapy. Ninety-seven percent of cases (n ¼ 72) were characterised as being aneuploid as measured by means of image cytometry. Preoperative radiotherapy (50 -68 Gy) resulted in significant reduction of proliferative activity in all patients for which post-treatment biopsies were available (P-value ¼ 0.001). Proliferative activity was not associated with response to radiation in stage II patients. However, we report a significant correlation between high proliferation rates and locoregional recurrences in stage I OTSCC patients (P-value ¼ 0.028). High-proliferative activity is thus related to an elevated risk of recurrence after surgery alone. We therefore conclude that Ki-67 expression level is a potentially useful clinical marker for predicting recurrence in surgically treated stage I OTSCC.

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Section: Discussionmentioning

confidence: 99%

Ki-67 expression predicts locoregional recurrence in stage I oral tongue carcinoma

et al. 2008

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“…Survival following surgical treatment depends on the pre-operative characteristics of tumour including positive nodes, thickness of the tumour ≥7mm, poorly differentiated tumour, the surgery itself, performance of neck dissection and post-operative positive resection margins (Lo et al, 2003;Manuel et al, 2003;Liu et al, 2010). Those patients treated by radiotherapy alone for advanced stage of disease have a shorter survival (Sargeran et al, 2008).…”

Section: Mortality and Survivalmentioning

confidence: 99%

“…Living in a disadvantaged neighbourhood with low individual socioeconomic status (SES) and having less or no education reduces the probability of 5570 survival (Yeole et al, 2000;Dikshit et al, 2012;Lee et al, 2012). At the national level, factors like life expectancy, gross national product, literacy rate, health expenditure, physician density and efficiency of health care system have a formative role in controlling the oral cancer mortality (Sargeran et al, 2008).…”

Section: Mortality and Survivalmentioning

confidence: 99%

Epidemiology of Oral Cancer in Asia in the Past Decade- An Update (2000-2012)

Rao¹,

Mejía²,

Roberts‐Thomson³

et al. 2013

Asian Pacific Journal of Cancer Prevention

393

273

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The prevalence of oral cancers (OC) is high in Asian countries, especially in South and Southeast Asia. Asian distinct cultural practices such as betel-quid chewing, and varying patterns of tobacco and alcohol use are important risk factors that predispose to cancer of the oral cavity. The aim of this review is to provide an update on epidemiology of OC between 2000 and 2012. A literature search for this review was conducted on Medline for articles on OC from Asian countries. Some of the articles were also hand searched using Google. High incidence rates were reported from developing nations like India, Pakistan, Bangladesh, Taiwan and Sri Lanka. While an increasing trend has been observed in Pakistan, Taiwan and Thailand, a decreasing trend is seen in Philippines and Sri Lanka. The mean age of occurrence of cancer in different parts of oral cavity is usually between 51-55 years in most countries. The tongue is the leading site among oral cancers in India. The next most common sites in Asian countries include the buccal mucosa and gingiva. The 5 year survival rate has been low for OC, despite improvements in diagnosis and treatment. Tobacco chewing, smoking and alcohol are the main reasons for the increasing incidence rates. Low socioeconomic status and diet low in nutritional value lacking vegetables and fruits contribute towards the risk. In addition, viral infections, such as HPV and poor oral hygiene, are other important risk factors. Hence, it is important to control OC by screening for early diagnosis and controlling tobacco and alcohol use. It is also necessary to have cancer surveillance at the national-level to collect and utilise data for cancer prevention and control programs.

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“…Su diagnóstico temprano, tiene un rol fundamental en su pronóstico y SV de los pacientes, mientras que los diagnósticos en etapas avanzadas tienen altos niveles de mortalidad. En la serie de casos analizados en este estudio, la SV global fue del 58,4%, en concordancia con lo reportado en otros países desarrollados, con porcentajes entre el 30% y 80% 4 , mientras que la mortalidad específi ca fue de 41,6%, similar a la tasa mundial, cercana al 50% 2 , demostrando que estos valores de mortalidad son elevados para esta patología.…”

Section: Discussionunclassified

“…Su evaluación pronóstica y terapéutica se ha basado principalmente en la clasifi cación clínica TNM 2 , la que ha mostrado, incluso con la medicina moderna, una tasa de mortalidad general alta. Según la literatura, características clínicas como la edad del paciente y el sitio anatómico de la lesión también deben ser consideradas 3,4 . Según la edad del paciente, factores de riesgo como el tabaco y el alcohol, afectarían principalmente a adultos mayores debido a una prolongada exposición.…”

Section: Introductionunclassified

Rol de las características clínicas e histológicas como factores pronósticos para la sobrevida en pacientes con carcinoma de células escamosas de la cavidad oral

et al. 2010

Rev Chil Cir

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Rol de las características clínicas e histológicas como factores pronósticos para la sobrevida en pacientes con carcinoma de células escamosas de la cavidad oral* Background: Survival of patients with oral squamous cell carcinoma is low and depends mostly on TNM staging of the tumor. Aim: To perform a retrospective analysis of a series of patients with oral squamous cell carcinoma. Material and Methods: Retrospective review of patients with the diagnosis, seen between 1995 and 2006 in a regional hospital. Host infl ammatory response and pattern of tumor invasion were assessed using the staging proposed by Bryne et al. Results: The medical records of 36 patients aged 39 to 89 years, were reviewed. During the study period, 15 patients died. Better survival was associated to a low pattern of tumor invasion and a high infl ammatory response and the topographic location of the tumor. Conclusions: Infl ammatory response, tumor invasion and location are associated with survival in oral squamous cell carcinoma.Key words: Oral cancer, squamous cell, survival. ResumenIntroducción: El carcinoma de células escamosas de la cavidad oral (CCECO) es una patología cuyo comportamiento es producto de interrelaciones con el huésped, esto es, por el patrón de invasión (PI) histopatológica y la respuesta infl amatoria (RI). El objetivo de este estudio es analizar las características clínicas e histopatológicas como factores pronóstico, en términos de supervivencia (SV) en pacientes con CCECO. Material y Método: Serie de casos. Se incluyeron pacientes diagnosticados en el Hospital Regional de Talca y Hospital Base de Curicó entre los años 1995 y 2006. Se revisaron las fi chas clínicas y biopsias de 36 pacientes con CCECO. Se determinó el Frente Invasivo Tumoral (FIT), evaluándose los parámetros propuestos por el sistema de graduación de Bryne (PI y RI) y factores de importancia clínica como localización topográfi ca de la lesión, edad y género, relacionándolos con SV mediante curvas de Kaplan-Meier y Log Rank test. Posteriormente, se aplicó una regresión de Cox para obtener un análisis multivariado y cálculo de RR. Del total de Rev.

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Survival after diagnosis of cancer of the oral cavity

Cited by 74 publications

References 17 publications

Ki-67 expression predicts locoregional recurrence in stage I oral tongue carcinoma

Ki-67 expression predicts locoregional recurrence in stage I oral tongue carcinoma

Epidemiology of Oral Cancer in Asia in the Past Decade- An Update (2000-2012)

Rol de las características clínicas e histológicas como factores pronósticos para la sobrevida en pacientes con carcinoma de células escamosas de la cavidad oral

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