Survival Advantage of Peritoneal Dialysis Relative to Hemodialysis in the Early Period of Incident Dialysis Patients: A Nationwide Prospective Propensity-Matched Study in Korea

Choi, Ji-Young; Jang, Hye Min; Park, Jongha; Kim, Yon Su; Kang, Shin-Wook; Yang, Chul Woo; Kim, Nam-Ho; Cho, Jang-Hee; Park, Sunhee; Kim, Chan‐Duck; Kim, Yong-Lim

doi:10.1371/journal.pone.0084257

Cited by 44 publications

(47 citation statements)

References 29 publications

(48 reference statements)

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“…There were no new risk factors that were specifically identified in this investigation. As noted in the results from this investigation, the aging of patients at the initiation of hemodialysis is becoming a problem in other countries as well [10,11]. The report from England indicates that the age of patients at the initiation of hemodialysis greatly influences the prognosis.…”

Section: Discussionmentioning

confidence: 59%

Survival rates and causes of death in Vietnamese chronic hemodialysis patients

Nguyen

Fukuuchi²

2017

Ren Replace Ther

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Background: Thirty years have passed since hemodialysis therapy first started in Vietnam. However, there have been no reports on information such as the survival rate, mortality, and cause of death of hemodialysis patients on a national level. The aim of this study is to retrospectively analyze the data on hemodialysis patients from the flagship hospital in Ho Chi Minh City and to shed light on the status of hemodialysis patients in Vietnam. Methods: The patients in this report were all 18 years or older who underwent hemodialysis at the Thong Nhat Hospital between April 1997 and December 2014. There were a total of 349 patients, with 225 males and 124 females. Data was collected on the age, sex, primary causes of end-stage renal diseases, starting date of hemodialysis, vascular access, hemodialysis therapy prescription, hemodialysis dose, coexisting conditions, clinical test data, and cause of death. IBM's statistical analysis software SPSS Statistics 23.0 was used. Results: The survival time after hemodialysis introduction was 5.27 ± 0.31 years (mean ± standard deviation). The factors which impacted the survival rate included being 60 years of age or older at the initiation of hemodialysis, being male, coexisting conditions, and vascular access apart from an artery venous fistula. The prognosis of diabetic patients suffering from renal failure was poor when compared to that of patients without diabetes; however, there was no statistical significance. The most common cause of death was cardiovascular disease (46.1%), followed by other causes (11.8%) and unknown causes (23.6%). Conclusions: Our data shows that mean survival time was shorter than that in other countries. One-year and 5-year survival rates were not so different. However, a 10-year survival rate was very low. Significant risk factors were not so special, but we have a problem in medical cost in Vietnam. To improve the long-term survival rate, we are trying to change the situation.

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Section: Discussionmentioning

confidence: 59%

Survival rates and causes of death in Vietnamese chronic hemodialysis patients

Nguyen

Fukuuchi²

2017

Ren Replace Ther

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“…shows the causes of death according to the TA-SUA levels. Overall, the 2 most common causes of death were infection (n= 62,30.1%) and a cardiogenic cause (n= 54, 26.2%), and the distribution of causes of death did not differ according to the TA-SUA levels.…”

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confidence: 93%

Lower serum uric acid level predicts mortality in dialysis patients

Bae

Cho

Shin³

et al. 2016

Medicine

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“…Cardiovascular disease was reported to be a leading cause of death in the ESRD patients from other cohorts [29] , [30] . In contrast, a Korean ESRD cohort was distinguished from other cohorts in that the prevalence of cardiovascular disease was relatively lower and infections were the most common cause of death [31] . In the general population, subclinical thyroid patients with high cardiovascular risk were associated with a higher mortality risk [32] – [34] , whereas patients with an average cardiovascular risk did not show such a relationship [35] , [36] .…”

Section: Discussionmentioning

confidence: 99%

Free Thyroxine Level as an Independent Predictor of Infection-Related Mortality in Patients on Peritoneal Dialysis: A Prospective Multicenter Cohort Study

et al. 2014

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BackgroundPrevious studies have reported the relationship between thyroid hormone levels and mortality in dialysis patients. However, little is known about the association of free thyroxine (fT4) and mortality in patients on peritoneal dialysis (PD). This study investigated the association between basal and annual variation in fT4 level and mortality in PD patients.MethodsPatients on maintenance PD were enrolled from a prospective multicenter cohort study in Korea; their serum triiodothyronine, fT4, and thyroid-stimulating hormone levels were measured 12 months apart. Patients with overt thyroid disease and those receiving thyroid hormone replacement therapy were excluded from the analysis. Patients were divided into two groups based on the median levels of fT4. The differences of all-cause, infection-related, and cardiovascular mortalities were analyzed between the two groups. The association of basal levels and annual variation with mortality was investigated with Kaplan–Meier curves and Cox proportional hazard models.ResultsAmong 235 PD patients, 31 (13.2%) deaths occurred during the mean follow-up period of 24 months. Infection (38.7%) was the most common cause of death. Lower basal fT4 levels were an independent predictor of all-cause and infection-related death (hazard ratio [HR] = 2.74, 95% confidence interval [CI] 1.27–5.90, P = 0.01, and HR = 6.33, 95% CI 1.16–34.64, P = 0.03, respectively). Longitudinally, patients with persistently lower fT4 levels during the 12-month period had significantly higher all-cause mortality than those with persistently higher levels (HR = 3.30, 95% CI 1.15–9.41, P = 0.03). The area under the receiver operating characteristic curve of fT4 for predicting all-cause and infection-related mortality was 0.60 and 0.68, respectively.ConclusionsfT4 level is an independent predictor of mortality and is especially attributable to infection in PD patients. This predictor was consistent when considering both baseline measurements and annual variation patterns. Close attention to infection in PD patients with relatively lower fT4 levels should be considered.

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Survival Advantage of Peritoneal Dialysis Relative to Hemodialysis in the Early Period of Incident Dialysis Patients: A Nationwide Prospective Propensity-Matched Study in Korea

Cited by 44 publications

References 29 publications

Survival rates and causes of death in Vietnamese chronic hemodialysis patients

Survival rates and causes of death in Vietnamese chronic hemodialysis patients

Lower serum uric acid level predicts mortality in dialysis patients

Free Thyroxine Level as an Independent Predictor of Infection-Related Mortality in Patients on Peritoneal Dialysis: A Prospective Multicenter Cohort Study

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