Survival advantage of lymphadenectomy in endometrial cancer

Eggemann, Holm; Ignatov, Tanja; Kaiser, Katharina; Burger, Elke; Costa, Serban Dan; Ignatov, Atanas

doi:10.1007/s00432-015-2109-9

Cited by 43 publications

(23 citation statements)

References 28 publications

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“…Although two prospective randomized trials 10 and a Surveillance, Epidemiology and End Results (SEER) Program analysis 11 have reported that systematic lymphadenectomy did not improve overall or disease-free survival in EC, there are still several studies suggesting that lymphadenectomy is beneficial for EC. 12,13 Predictions of LNM are well studied in EC patients, especially in FIGO stage I. One recent study constructed a nomogram for predicting the overall survival and found the nomogram was more accurate than the Mayo criteria.…”

Section: Discussionmentioning

confidence: 99%

<p>Increased Serum Calcium Level Promotes the Risk of Lymph Node Metastasis in Endometrial Cancer</p>

Dong

Cheng

et al. 2020

CMAR

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The early predictive values of diagnostic markers for lymph node metastasis (LNM) in endometrial cancer (EC) are still unclear at present. The purpose of this study is to explore the relationship between serum calcium and LNM in EC. Methods: We identified all patients with EC who underwent surgery between January 2012 and December 2016. Patient characteristics and various preoperative clinicopathologic data were obtained from medical records and were reviewed retrospectively. These patients were divided into two groups according to the pathology of their lymph node. Logistic regression models analyzed the relationship between the ionized calcium and LNM of EC patients, while adjusting for the potential confounders. Results: A total of 448 patients were assessed. Univariate analysis showed that ionized calcium, CA125 level, tumor grade, peritoneal cytology, FIGO stage, histological type, LVSI, and myometrial invasion were positively correlated with LNM (all P<0.05). The risk of LNM increased with the promotion of serum ionized calcium (P for trend <0.01). Ionized calcium level was significant before and after the adjustment of cofounders (unadjusted: OR=11.9, 95% CI: 4.8-29.6, P< 0.01; model I: OR=11.3, 95% CI: 4.5-28.8, P< 0.01; model II: OR=5.2, 95% CI: 1.6-17.2, P< 0.05). Additionally, the risk of ionized calcium was especially evident in patients whose age was older than 60, BMI<28 kg/m 2 , grade 3, negative peritoneal cytology and endometrioid endometrial adenocarcinoma. Conclusion: Ionized calcium level was highly associated with LNM in EC and acted as a potential biomarker in predicting the risk of LNM in EC.

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Section: Discussionmentioning

confidence: 99%

<p>Increased Serum Calcium Level Promotes the Risk of Lymph Node Metastasis in Endometrial Cancer</p>

Dong

Cheng

et al. 2020

CMAR

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“…The recent debate focused on the value of routine lymphadenectomy in patients with EC comprises a three-fold controversy: first, randomized trials suggest the absence of survival benefit in patients undergoing systematic lymphadenectomy; second, potential post-operative morbidity following lymphadenectomy may jeopardize the patients' quality of life; and third, difficulty in procedural lymphadenectomy in obese patients is gradually increasing in a substantial proportion of the patient population (8081). Emerging evidence supports the survival benefit of systematic lymphadenectomy in select patients with EC at intermediate or high risk for nodal metastasis (8283). This highlights the importance of risk stratification in patients with indication of lymphadenectomy, to balance the therapeutic benefit against perioperative morbidity and mortality.…”

Section: Endometrial Carcinomamentioning

confidence: 93%

“…This highlights the importance of risk stratification in patients with indication of lymphadenectomy, to balance the therapeutic benefit against perioperative morbidity and mortality. However, in current clinical setting, optimal pre-operative risk assessment remains difficult (83).…”

Section: Endometrial Carcinomamentioning

confidence: 99%

Current Status of Magnetic Resonance Imaging in Patients with Malignant Uterine Neoplasms: A Review

Huang

et al. 2019

Korean J Radiol

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In this study, we summarize the clinical role of magnetic resonance imaging (MRI) in the diagnosis of patients with malignant uterine neoplasms, including leiomyosarcoma, endometrial stromal sarcoma, adenosarcoma, uterine carcinosarcoma, and endometrial cancer, with emphasis on the challenges and disadvantages. MRI plays an essential role in patients with uterine malignancy, for the purpose of tumor detection, primary staging, and treatment planning. MRI has advanced in scope beyond the visualization of the many aspects of anatomical structures, including diffusion-weighted imaging, dynamic contrast enhancement-MRI, and magnetic resonance spectroscopy. Emerging technologies coupled with the use of artificial intelligence in MRI are expected to lead to progressive improvement in case management of malignant uterine neoplasms.

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“…The included studies were published between 2007 and 2016. Four studies were studies were conducted in Japan, [ 7 , 10 , 16 ] 3 in Korea, [ 15 , 17 ] 1 in Turkey, [ 12 ] 1 in Germany, [ 11 ] 1 in USA. [ 13 ] The average of follow-up duration was 46 months.…”

Section: Resultsmentioning

confidence: 99%

Survival benefits of pelvic lymphadenectomy versus pelvic and para-aortic lymphadenectomy in patients with endometrial cancer

Guo

Cai

et al. 2018

Medicine

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Survival advantage of lymphadenectomy in endometrial cancer

Abstract: Pelvic/para-aortic lymphadenectomy should be performed in all patients with endometrial cancer at intermediate and high risk of recurrence.

Cited by 43 publications

References 28 publications

<p>Increased Serum Calcium Level Promotes the Risk of Lymph Node Metastasis in Endometrial Cancer</p>

<p>Increased Serum Calcium Level Promotes the Risk of Lymph Node Metastasis in Endometrial Cancer</p>

Current Status of Magnetic Resonance Imaging in Patients with Malignant Uterine Neoplasms: A Review

Survival benefits of pelvic lymphadenectomy versus pelvic and para-aortic lymphadenectomy in patients with endometrial cancer

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