Survey on treatments for primary headaches in 13 specialized juvenile Headache Centers: The first multicenter Italian study

Toldo, Irene; Rattin, M.; Perissinotto, Egle; Carlo, Debora De; Bolzonella, Barbara; Nosadini, Margherita; Rossi, Livia N.; Vecchio, A; Simonati, Alessandro; Carotenuto, Marco; Scalas, Cinzia; Sciruicchio, Vittorio; Raieli, Vincenzo; Tozzi, E.; Valeriani, Massimiliano; Cianchetti, Carlo; Balottin, Umberto; Guidetti, Vincenzo; Sartori, Stefano; Battistella, Pier Antonio

doi:10.1016/j.ejpn.2016.12.009

Cited by 25 publications

(27 citation statements)

References 40 publications

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“…Methods Adults with EM (n=955) were randomised 1:1:1 to subcutaneous monthly placebo or erenumab 70 mg or 140 mg for 24 weeks. The primary endpoint was change from baseline in mean monthly migraine days (MMDs) over weeks [13][14][15][16][17][18][19][20][21][22][23][24]. Secondary endpoints were ≥50% reduction in MMDs; change in acute migraine-specific medication days; change in Physical Impairment (PI) and Impact on Everyday Activities (EA) (as measured by the Migraine Physical Function Impact Diary [MPFID]).…”

Section: Resultsmentioning

confidence: 99%

“…In a multicentre study of 637 young M and TTH patients, supplements and melatonin were used respectively by 205 (32%) and 61 (10%) patients with a good/excellent efficacy in 68% and 75% of cases respectively, without differences between the two headache types [19]. …”

Section: C) Italian Experience In Specialized Juvenile Headache Centersmentioning

confidence: 99%

“…The MFIQ was completed at baseline and every 4 weeks for 24 weeks. The MFIQ scores were evaluated as change from baseline to the last three months of the double-blind treatment phase (defined as the average of scores in Months 4-6 [Weeks [13][14][15][16][17][18][19][20][21][22][23][24] Background Migraine Physical Function Impact Diary (MPFID) is a 13-item patientreported outcome (PRO) measure that assesses the impact of migraine on Everyday Activities (EA) and Physical Impairment (PI) domains. We report the effect of erenumab, a preventive treatment for episodic migraine (EM) in adults, on monthly days with impairment as measured by the MPFID.…”

Section: Introductionmentioning

confidence: 99%

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11th European Headache Federation Congress jointly with 31st Congress of the Italian Society for the Study of Headaches

Fierro¹,

Cosentino²,

Cillino

et al. 2017

J Headache Pain

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Section: Resultsmentioning

confidence: 99%

Section: C) Italian Experience In Specialized Juvenile Headache Centersmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

11th European Headache Federation Congress jointly with 31st Congress of the Italian Society for the Study of Headaches

Fierro¹,

Cosentino²,

Cillino

et al. 2017

J Headache Pain

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“…Treatment of primary headache can prove difficult; although many different medications are used in the acute treatment, only triptans and ibuprofen have some proven effect on pain reduction, but both are associated with adverse events such as fatigue, dizziness, dry mouth, nausea or vomiting, and can even result in headaches due to medication overuse [25, 33]. A recent study showed that the commonly used preventive medications, amitriptyline and topiramate, were as effective as placebo in the reduction of the number of headaches and had higher rates of adverse events [23].…”

Section: Introductionmentioning

confidence: 99%

Hypnotherapy or transcendental meditation versus progressive muscle relaxation exercises in the treatment of children with primary headaches: a multi-centre, pragmatic, randomised clinical study

et al. 2018

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Many children suffer from headaches. Since stress may trigger headaches, effective techniques to cope with stress are needed. We investigated the effectiveness of two mind-body techniques, transcendental meditation (TM) or hypnotherapy (HT), and compared them with progressive muscle relaxation (PMR) exercises (active control group). Children (9–18 years) suffering from primary headaches more than two times per month received either TM (N = 42), HT (N = 45) or PMR (N = 44) for 3 months. Primary outcomes were frequency of headaches and ≥ 50% reduction in headaches at 3 and 9 months. Secondary outcomes were adequate relief, pain coping, anxiety and depressive symptoms, somatisation and safety of treatment. Groups were comparable at baseline. Headache frequency was significantly reduced in all groups from 18.9 days per month to 12.5 and 10.5 at respectively 3 and 9 months (p < 0.001), with no significant differences between the groups. Clinically relevant headache reduction (≥ 50%) was observed in 41% and 47% of children at 3 and 9 months respectively, with no significant differences between the groups. No differences were observed in secondary outcome measures between the intervention groups. No adverse events were reported.Conclusion: All three techniques reduced primary headache in children and appeared to be safe.Trial registration: NTR 2955, 28 June 2011 (www.trialregister.nl) What is Known: • Stress may be an important trigger for both tension type headache and migraine in children. • Good data are lacking on the effect of transcendental meditation, hypnotherapy or progressive muscle relaxation as possible stress-reducing therapies in children with primary headaches. What is New: • Three non-pharmacological techniques, i.e., transcendental meditation, hypnotherapy and progressive muscle relaxation exercises, all result in a clinically significant reduction of headaches and use of pain medication. • No large differences between the three techniques were found, suggesting that children can choose either one of the three techniques based on personal preferences.

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“…Therefore, it is of great concern to find effective herb medicines [22] and nonpharmacological treatment methods. [23] …”

Section: Introductionmentioning

confidence: 99%

Hypouricemic and arthritis relapse-reducing effects of compound tufuling oral-liquid in intercritical and chronic gout

Xie

Jing

et al. 2017

Medicine

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Survey on treatments for primary headaches in 13 specialized juvenile Headache Centers: The first multicenter Italian study

Cited by 25 publications

References 40 publications

11th European Headache Federation Congress jointly with 31st Congress of the Italian Society for the Study of Headaches

11th European Headache Federation Congress jointly with 31st Congress of the Italian Society for the Study of Headaches

Hypnotherapy or transcendental meditation versus progressive muscle relaxation exercises in the treatment of children with primary headaches: a multi-centre, pragmatic, randomised clinical study

Hypouricemic and arthritis relapse-reducing effects of compound tufuling oral-liquid in intercritical and chronic gout

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