11th European Headache Federation Congress jointly with 31st Congress of the Italian Society for the Study of Headaches

Fierro, Brigida; Cosentino, Giuseppe; Cillino, Salvatore; Brighina, Filippo; Firpo, Viviana

doi:10.1186/s10194-017-0817-z

Cited by 7 publications

(3 citation statements)

References 7 publications

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“…Several SRs examined the e cacy of acupuncture [11,42], BoNT-A [5,43], or topiramate [10,44,45] in migraine prophylaxis. Most of the SRs focused on the e cacy of the 3 treatments in episodic migraine; and none of them has compared the 3 treatments by combining both direct and indirect evidence.…”

Section: Discussionmentioning

confidence: 99%

Effectiveness of botulinum neurotoxin A, topiramate, and acupuncture in preventive treatment of chronic migraine: a network meta-analysis

Zheng

Huang

Chen

et al. 2020

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Background Botulinum neurotoxin A (BoNT-A) was the primary choice for preventive treatment of chronic migraine. Topiramate and acupuncture showed promising effect for the condition, but their effectiveness relative to BoNT-A was rarely studied. We aimed to perform a network meta-analysis to compare the effectiveness and acceptability between BoNT-A, topiramate, and acupuncture.Methods We searched OVID Medline, Embase, the Cochrane register of controlled trials (CENTRAL), the Chinese Clinical Trial Register, and clinicaltrials.gov for randomized controlled trials (RCTs) that compared BoNT-A, topiramate, and acupuncture with any of them or placebo in the preventive treatment of chronic migraine. Two independent reviewers screened RCTs, extracted data, and assessed risk of bias. A network meta-analysis was performed by using a frequentist approach and a random-effects model. The primary outcomes were reduction in monthly headache days and monthly migraine days at week 12. Acceptability was assessed by adverse event rate. The effect size of the primary outcomes was measured by using standard mean difference (SMD).Results We included 15 RCTs (n = 2545). Eleven RCTs were at low risk of bias. The network meta-analyses (n = 2061) showed that acupuncture (2061 participants; SMD − 1.61, 95%CI -2.35 to -0.87) and topiramate(582 participants; SMD − 0.4, 95%CI -0.75 to -0.04) ranked the most effective in the reduction of monthly headache days and migraine days, respectively; but they were not significantly superior over BoNT-A. Topiramate caused the most treatment-related adverse events and the highest rate of dropouts owing to adverse events.Conclusions Topiramate and acupuncture were not superior over BoNT-A. In terms of acceptability and accessibility of treatments, BoNT-A was still the primary choice for preventive treatment of chronic migraine.

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Section: Discussionmentioning

confidence: 99%

Effectiveness of botulinum neurotoxin A, topiramate, and acupuncture in preventive treatment of chronic migraine: a network meta-analysis

Zheng

Huang

Chen

et al. 2020

Preprint

View full text Add to dashboard Cite

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“…Second, the findings about the prophylactic treatment are largely affected by the drop-outs and are not placebo controlled. This last point is particularly important, considering the open debate about the efficacy of placebo in children (27–30).…”

Section: Discussionmentioning

confidence: 99%

“…The data of the present study had been presented at 11th European Headache Federation Congress jointly with 31st Congress of the Italian Society for the Study of Headaches Rome, Italy. 01–03 December 2017 (30).…”

mentioning

confidence: 99%

Features of Primary Chronic Headache in Children and Adolescents and Validity of Ichd 3 Criteria

et al. 2019

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Introduction: Chronic headaches are not a rare condition in children and adolescents with negative effects on their quality of life. Our aims were to investigate the clinical features of chronic headache and usefulness of the International Classification of Headache Disorders 3rd edition (ICHD 3) criteria for the diagnosis in a cohort of pediatric patients.Methods: We retrospectively reviewed the charts of patients attending the Headache Center of Bambino Gesù Children and Insubria University Hospital during the 2010–2016 time interval. Statistical analysis was conducted to study possible correlations between: (a) chronic primary headache (CPH) and demographic data (age and sex), (b) CPH and headache qualitative features, (c) CPH and risk of medication overuse headache (MOH), and (d) CPH and response to prophylactic therapies. Moreover, we compared the diagnosis obtained by ICHD 3 vs. ICHD 2 criteriaResults: We included 377 patients with CPH (66.4% females, 33.6% males, under 18 years of age). CPH was less frequent under 6 years of age (0.8%; p < 0.05) and there was no correlation between age/sex and different CPH types. The risk to develop MOH was higher after 15 years of age (p < 0.05). When we compared the diagnosis obtained by ICHD 2 and ICHD 3 criteria we found a significant difference for the undefined diagnosis (2.6% vs. 7.9%; p < 0.05), while the diagnosis of probable chronic migraine was only possible by using the ICHD2 criteria (11.9% of patients; p < 0.05). The main criterion which was not satisfied for a definitive diagnosis was the duration of the attacks less than 2 h (70% of patients younger than 6 years; p < 0.005). Amitriptyline and topiramate were the most effective drugs (p < 0.05), although no significant difference was found between them (p > 0.05).Conclusion: The ICHD 3 criteria show limitations when applied to children under 6 years of age. The risk of developing MOH increases with age. Although our “real word” study shows that amitriptyline and topiramate are the most effective drugs regardless of the CPH type, the lack of placebo-controlled data and the limited follow-up results did not allow us to conclude about the drug efficacy.

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11th European Headache Federation Congress jointly with 31st Congress of the Italian Society for the Study of Headaches

Cited by 7 publications

References 7 publications

Effectiveness of botulinum neurotoxin A, topiramate, and acupuncture in preventive treatment of chronic migraine: a network meta-analysis

Effectiveness of botulinum neurotoxin A, topiramate, and acupuncture in preventive treatment of chronic migraine: a network meta-analysis

Features of Primary Chronic Headache in Children and Adolescents and Validity of Ichd 3 Criteria

Griffonia simplicifolia/magnesium/tanacetum parthenium

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